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Diss Factsheets
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EC number: 611-575-8 | CAS number: 577953-88-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to reproduction: other studies
Administrative data
- Endpoint:
- toxicity to reproduction: other studies
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Guideline study; original reference in Japanese, compilation of data from English summary and tables
Data source
Reference
- Title:
- No information
- Author:
- Ohara N, Takashima H, Tanaka A, Katoh H, Seki T, Kojima K,|Inada H, Anjo T, Azegami J, Yoshimura S, Saegus K (1998).|Twenty-eight-day repeat oral dose toxicity test of|dicyclohexylamine in rats. Ministry of health and Welfare|(MHW, Japan) Toxicity Testing Reports of Environmental|Chemicals Vol. 6, 101-104, 105-116, 637-642.
Materials and methods
- Principles of method if other than guideline:
- Type: other: Sub-acute toxicity study
Method: other: Guidelines for 28 day Repeat Dose Toxicity Test of Chemicals (Japan) - GLP compliance:
- yes
- Type of method:
- in vivo
Test material
- Reference substance name:
- Dicyclohexylamine
- EC Number:
- 202-980-7
- EC Name:
- Dicyclohexylamine
- Cas Number:
- 101-83-7
- IUPAC Name:
- N-cyclohexylcyclohexanamine
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Crj: CD(SD)
Administration / exposure
- Route of administration:
- oral: gavage
- Duration of treatment / exposure:
- 28 days
- Frequency of treatment:
- one daíly
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0, 20, 70, 200 mg/kg bw dissolved in corn oil
Basis:
- Control animals:
- yes, concurrent vehicle
- Details on study design:
- Duration of test: 42 days (28 days treatment + 14 days recovery)
Results and discussion
Observed effects
Any other information on results incl. tables
RS-Freetext:
-Clinical signs: Salivation, convulsion observed in male and
female rats from 70 mg/kg bw/day onwards which disappeared
during recovery period.
200 mg-groups, male and females:
--Mortality: 8/13; reason of death unknown, 1/18 with
myocardial degeneration
--Body weight gain(as graphic): significantly decreased,
continued (but not significant) until the end of the
recovery period:
FINAL BODY WEIGHTS, m/f: control versus high dose:
end of treatment time: 355g/232g versus 285g/184g
end of recovery period: 399.9g/266g versus 333g/236g
--Food consumption(graphic): significantly reduced but had
recovered by the end of the test
GROSS AND HISTOPATHOLOGY
--ORGAN WEIGHTS (significant changes):
-----adrenal gland
absolute//relative(mg//mg/g), high dose versus control
---male: 62.5//0.220 versus 47.3//0.134
---female: 88.2//0.478 versus 61.0//0.263
-----ovaries
absolute//relative(mg//mg/g), mid, high dose versus control
---female: 79.6(p<0.05)//0.357, 59,9//0.352 versus
98.2//0.425
--HISTOPATHOLOGY
no relevant changes in comparison to the concurrent controls
reported
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.