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Diss Factsheets
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EC number: 947-646-8 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The study was performed by a GLP accredited laboratory although this study was not performed to GLP. The procedures used in the study were based on EEC methodology and are sufficient to conclude on the classification and labeling of the substance.
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 996
- Report date:
- 1996
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- no
Test material
- Reference substance name:
- Reaction mass of mixed xylenes and sulphur monochloride
- IUPAC Name:
- Reaction mass of mixed xylenes and sulphur monochloride
- Reference substance name:
- DXDS
- IUPAC Name:
- DXDS
- Details on test material:
- - Name of test material (as cited in study report): DXDS (Dixylyldisulphide)
- Physical state: Liquid
- Analytical purity: Approximately 100%
- Purity test date: 04/07/1995
- Lot/batch No.: SMD95/14
- Expiration date of the lot/batch: 6th Jan 1996
- Storage condition of test material: Room temperature in the dark
Constituent 1
Constituent 2
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- not specified
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 mls undiluted - Duration of treatment / exposure:
- 4 hours
- Observation period:
- Maximum of 14 days
- Number of animals:
- Two females
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing (if done): washed to removed residual test sbstance.
- Time after start of exposure: 4 hours
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- other: 72hours
- Score:
- ca. 1.3
- Max. score:
- 2
- Reversibility:
- fully reversible within: 8 days
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- other: 72 hours
- Score:
- ca. 1
- Max. score:
- 1
- Reversibility:
- fully reversible within: 4 days
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- other: 72 hours
- Score:
- ca. 2
- Max. score:
- 2
- Reversibility:
- not fully reversible within: 14 days
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Time point:
- other: 72 hours
- Score:
- ca. 2
- Max. score:
- 2
- Reversibility:
- not fully reversible within: 14 days
Any other information on results incl. tables
The results are presented in the table below:
Animal |
E= Erythema O=Oedema |
Day |
|||||||||||||
1* |
2 |
3 |
4 |
5 |
6 |
7 |
8 |
9 |
10 |
11 |
12 |
13 |
14 |
||
3572 |
E |
2a |
1a |
1a |
1a |
1a |
1b |
1b |
0b |
0b |
0 |
Study terminated |
|||
O |
1 |
1 |
1 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
|||||
3573 |
E |
2a |
2a |
2a |
2 |
2 |
2b |
2b |
2b |
2b |
2b |
2b |
2b |
1b |
1 |
O |
2 |
2 |
2 |
2 |
2 |
2 |
2 |
2 |
1 |
1 |
2 |
1 |
1 |
1 |
* Approximately 60 minutes after removal of the dressing
aResidual yellow staining from the test material
bDesquamation (characterised by dryness and sloughing on the treatment site).
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Mild irritancy is observed in the study however this is insufficient to trigger classification for skin irritancy, therefore no classification is required.
- Executive summary:
A non-GLP study was performed to determine the effect of DXDS on intact rabbit skin. The test item was applied to the intact skin of two female rabbits using a semi-occlusive dressing for a period of 4 hours. After exposure, the dressings were removed and the test sites washed to remove residual test item. The test sites were observed for a maximum of 14 days and the observations recorded.
Well defined erythema and slight oedema accompanied by desquamation of the stratum corneum were observed in one animal,
well defined erythema and very slight oedema accompanied by desquamation of the stratum corneum were observed in the second animal. The mean scores over a 72 hour period for erythema for each animal were 1.3 and 2.0 and for oedema 1.0 and 2.0.
Mild effects were observed at the end of the 14 day observation period in one animal with the effects being reversible in the second animal. Based on the mean scores for erythema and oedema being < 2.3, no classification for skin irritancy is required.
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