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Diss Factsheets
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EC number: 232-504-3 | CAS number: 8060-28-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Vapour pressure
Administrative data
Link to relevant study record(s)
- Endpoint:
- vapour pressure
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Justification for type of information:
- Hop extract is a multi-component UVCB. Hop extract has a long history of use as an food ingredient in the manufacture of beer, and it has GRAS status in the USA. It has therefore been used safely, both in the EU and worldwide, for a considerable number of years. Since it is a UVCB, the precise composition can vary, but detailed compositional information is given in the boundary composition. Briefly, the major components of hop extract are the alpha acids, the beta acids and the hop essential oil. The hop essential oil is the only component for which there is a predicted significant vapour pressure. Hop essential oil makes up 0 - 40% of a hop extract. Hop oil itself made up of a very large number of components, but the major three components are myrcene, humulene and caryophyllene. Even an essential oil-rich hop extract has a viscosity of 1 - 3 Pa.s at 30 - 40 oC (Barth Haas Group internal company data), that is, a viscosity substantially above that of water. A hop extract is not therefore likely to pose an inhalation hazard risk. The other safety hazard pertaining to vapour pressure is the environmental fate and biodegradation of hop extract. Hop extract is produced by ethanol or carbon dioxide extraction of hop cones – this is a “natural” extract under food legislation, although solvent extracts are not considered as “natural” under REACH, unless extracted simply by water, hence the REACH registration. Nevertheless, hop extract is effectively a natural extract. Taking into account the compositional and potential safety data, it is reasonable to estimate the vapour pressure of a hop extract based on its most volatile component, namely myrcene. This has been done for this end point.
- Qualifier:
- according to guideline
- Guideline:
- other: Gas chromatography based retention index method
- Version / remarks:
- Details are given in the reference A van Roon et al (2002) J. Chromatog. A vol 955, pp. 102-115. A gas chromatography method was used, with n-alkanes as reference compounds, determining Kovats retention indices, and using an equilibrium fugacity model. The results obtained were compared with published literature values.
- Principles of method if other than guideline:
- Details are given in the reference A van Roon et al (2002) J. Chromatog. A vol 955, pp. 102-115. A gas chromatography method was used, with n-alkanes as reference compounds, determining Kovats retention indices, and using an equilibrium fugacity model. The results obtained were compared with published literature values.
- GLP compliance:
- not specified
- Type of method:
- other: See A van Roon et al (2002) J. Chromatog. A vol 955, pp. 102-115. A gas chromatography method was used, with n-alkanes as reference compounds, determining Kovats retention indices, and using an equilibrium fugacity model.
- Key result
- Temp.:
- 298.15 K
- Vapour pressure:
- ca. 1.38 < mm Hg
- Conclusions:
- The vapour pressure can be taken to be equal or less than that of the UVCB's principal volatile component, namely myrcene.
Reference
Description of key information
Key value for chemical safety assessment
- Vapour pressure:
- 0.184 kPa
- at the temperature of:
- 298.15 K
Additional information
Based on the most volatile component on this UVCB, namely myrcene.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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