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EC number: 239-717-0 | CAS number: 15647-11-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1980-08 to 1980-10
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 981
- Report date:
- 1981
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Principles of method if other than guideline:
- comparable to guideline Methode OECD 401
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 3-aminomethyl-3,5,5-trimethylcyclohexan-1-ol
- EC Number:
- 239-717-0
- EC Name:
- 3-aminomethyl-3,5,5-trimethylcyclohexan-1-ol
- Cas Number:
- 15647-11-7
- Molecular formula:
- C10H21NO
- IUPAC Name:
- 3-(aminomethyl)-3,5,5-trimethylcyclohexan-1-ol
- Test material form:
- liquid: viscous
- Details on test material:
- 3-aminomethyl-3,5,5-trimethylcyclohexan-1-ol
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- - Source: W. Gassner, Sulzfeld
- Weight at study initiation: 110-130 g
Environmental conditions:
Keeping of animals: diet: Ssniff R 10 pellets;
Water ad libitum;
Room temperature 22°C +/- 1C°C
Light 12 hours per day,
Diet deprived 16 hours before oral application of test substance
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- - Doses: calculated from volume
- Doses per time period: single dose (gavage) - Doses:
- 1.6 / 2.0 / 2.5 / 3.2 ml/kg bw
- No. of animals per sex per dose:
- 5 male and 5 female per dose
- Control animals:
- yes
- Remarks:
- 4.0 ml Aqua dest/kg bw.
- Details on study design:
- - Volume administered or concentration: undiluted test substance: 1.6 / 2.0 / 2.5 / 3.2 ml/kg bw, control animals: 4.0 ml Aqua dest/kg bw.
- Post dose observation period: 14 days
EXAMINATIONS:
- Frequency of observations: The animals were observed for deaths or overt signs of toxicity twice after dosing and subsequently once daily for fourteen days.
central nervous system, lung, heart, heart sac, stomach, large intestine, small intestine, liver, spleen, kidneys, serosa, lymph nodes, gonads, perineum - Statistics:
- - LD50 calculation: according to Weil, C.S. (Biometrics, 8, 249, 1952)
Results and discussion
- Preliminary study:
- not applicable
Effect levelsopen allclose all
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 2.1 mL/kg bw
- 95% CL:
- >= 1.9 - <= 2.3
- Remarks on result:
- other: Volume/kg bw
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 2 142 mg/kg bw
- 95% CL:
- > 1 938 - < 2 346
- Remarks on result:
- other: Mass/kg bw
- Mortality:
- - Time of death: within 24 hours
- Number of deaths at each dose 14 days after substance application: control: 0/10; 1.6 ml/kg: 0/10 ; 2.0 ml/kg: 7/10 ; 2.5 ml/kg: 7/10; 3.2 ml/kg: 10/10;
- LD50 (14 days) = 2.10 ml/kg confidence interval: 1.9 - 2.3 ml/kg - Clinical signs:
- other: increase of locomotive behaviour, piloerection, sedation, in higher dose groups also increasing gnawing
- Gross pathology:
- NECROPSY FINDINGS:
Moderate hyperemia, congestion of liver, reddening of stomach and bloody intestinal mucosa of dead animals.
No findings at the end of post exposure period.
Any other information on results incl. tables
table of results see under attached background material
Applicant's summary and conclusion
- Conclusions:
- Treatment related mortality and other sublethal symptoms were observed in rats within the 14 day post-dosing period for the doses used in this acute oral toxicity study. The LD50 (oral) was calculated to be LD50 (14 days) = 2.10 ml/kg.
- Executive summary:
The test item was applied once to 4 dose-groups of rats (5 male and 5 female Sprague Dawley rats per dose-group) in doses of 1.6 / 2.0 / 2.5 / 3.2 ml/kg bw of undiluted test item. Control animals was applied once to 4.0 ml aqua dest/kg bw.
The observation period was 14 days.
In all doses groups a increase of locomotive behaviour, piloerection, sedation, in higher dose groups also increasing gnawing was observed beginning 1 h after dosing and lasting 24 hours.
At the highest dose (3.2 ml/kg bw) all animals died within 24 hours after oral application of the test item. Necroscopy findings were moderate hyperemia, congestion of liver, reddening of stomach and bloody intestinal mucosa. There were no findings at the end of post exposure period.
According to this study the LD50 value (oral) was determined to be 2.1 ml/kg bw in rats for the test item
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