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EC number: 242-560-0 | CAS number: 18765-38-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 21 January to 7 February 1992
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 992
- Report date:
- 1992
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Tetrakis(2-butoxyethyl) orthosilicate
- EC Number:
- 242-560-0
- EC Name:
- Tetrakis(2-butoxyethyl) orthosilicate
- Cas Number:
- 18765-38-3
- Molecular formula:
- C24H52O8Si
- IUPAC Name:
- tetrakis(2-butoxyethyl) orthosilicate
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Bor: WISW (SPF cpb)
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Fa. Winkelmann
- Age at study initiation: 6-8 weeks
- Weight at study initiation:200-300 g
- Fasting period before study: None
- Diet: Ad libitum.
- Water: Ad libitum
- Acclimation period: Five days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20± 3
- Humidity (%): 30-70
- Air changes (per hr): no data
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Type of coverage:
- semiocclusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- % coverage: 10% of body surface was shaved.
- Type of wrap if used: Semi-occlusive
REMOVAL OF TEST SUBSTANCE
- Time after start of exposure: Patch removed after 24 hours.
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 2.07 cm3/kg bw
- Constant volume or concentration used: yes - Duration of exposure:
- 24 hours
- Doses:
- One limit dose of 2000 mg/kg bw
- No. of animals per sex per dose:
- Five
- Control animals:
- not required
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations for clinical signs: 0.5, 1, 2, 3, 4, 5 and 6 hours, and then daily up to two weeks post-exposure.
- Necropsy of survivors performed: yes
- Other examinations performed: Body weights recorded on the day of exposure and on day 7. Macroscopy changes were recorded following sacrifice on day 14.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Mortality:
- No deaths occurred.
- Clinical signs:
- No clinical signs
- Body weight:
- Normal weight gain
- Gross pathology:
- No changes to skin and subcutaneous tissues. Two males and one female had swollen and red stomach mucosa glands, and sometimes reddening of the small bowel mucosa.
- Other findings:
- No other findings.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Under the conditions of a good quality OECD 402 study that was conducted to GLP, the dermal LD50 was greater than 2000 mg/kg bw in male and female rats as no deaths occurred.
- Executive summary:
In an OECD 402 study, conducted to GLP, 2000 mg/kg bw test material was applied under a semi-occlusive dressing for 24 hours on the shaved, intact skin of five male and five female rats. Animals were observed for two weeks following removal of the patch, and body weights recorded. All animals were subject to necropsy and examined macroscopically. No deaths or clinical signs were observed in any of the animals. Body weight gains were not affected by treatment. There were no changes to skin and subcutaneous tissues. Two males and one female had swollen and red stomach mucosa glands, and sometimes reddening of the small bowel mucosa. The dermal LD50 in rats is therefore >2000 mg/kg bw.
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