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Diss Factsheets
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EC number: 207-950-7 | CAS number: 502-69-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1988
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 988
- Report date:
- 1988
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Principles of method if other than guideline:
- Method: other: BASF-Test
- GLP compliance:
- no
- Limit test:
- yes
Test material
- Reference substance name:
- 6,10,14-trimethylpentadecan-2-one
- EC Number:
- 207-950-7
- EC Name:
- 6,10,14-trimethylpentadecan-2-one
- Cas Number:
- 502-69-2
- Molecular formula:
- C18H36O
- IUPAC Name:
- 6,10,14-trimethylpentadecan-2-one
- Details on test material:
- Purity: unknown
Density: 0.834 g/ml
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Dr. K. Thomae GmbH, 7950 Biberach, Germany
- Weight at study initiation: male: 268 g, female: 238 g
- Identification: cage cards
- Housing: single housing in stainless steel wire mesh cage (type DK-III, Becker & Co., Castrop-Rauxel, Germany)
- Diet (e.g. ad libitum): KLIBA-Labordiät 343, Klingenthalmühle AG, CH-4303 Kaiseraugst, ad libitum
- Water (e.g. ad libitum): tap water ad libitum
- Acclimation period: at least 1 week
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20-24
- Humidity (%): 30-70
- Photoperiod (hrs dark / hrs light): 12 / 12
Administration / exposure
- Type of coverage:
- semiocclusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- - application area: about 50 cm²
- route of application: single application to the clipped epidermis (dorsal and dorsolateral parts of the trunk)
- clipping of the fur: at least 15 hours before beginning of thy study
- application: in the morning, Aug. 25, 1988
- coverage of the application site with a semiocclusive dressing (four layers of absorbent gauze and porous bandage) for 24 hours
- afterwards: removal of the dressing and rinsing of the application site with warm water - Duration of exposure:
- 24 h
- Doses:
- 2000 mg/kg bw (= 2,4 ml/kg bw)
- No. of animals per sex per dose:
- 5
- Details on study design:
- - Duration of observation period following administration: 14 days
- signs and symptoms: recording several times on the day of application and then at least once each workday
- check for moribund and dead animals: twice each workday and once on holidays
- scoring of skin findings: 30-60 min after removal of the semiocclusive dressing and then about one week later and before termination of the study
- pathology: withdrawal of food about 16 hours before sacrifice with CO2; then necropsy with gross-pathological examination; necropsy of all animals that die as early as possible
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- none during 24 hours exposure and 14 day observation period
- Clinical signs:
- symptoms: no abnormalities
erythema: only on day 1 in males and females - Body weight:
- mean weight male [g]:
268 day 0
293 day 7
317 day 13
mean weight female [g]:
238 day 0
243 day 7
253 day 13 - Gross pathology:
- sacrificed animals (male+female): no pathological findings noted
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
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