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EC number: 604-144-0 | CAS number: 139525-77-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
- Endpoint:
- biodegradation in water: inherent biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2007
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 007
- Report date:
- 2008
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 302 B (Inherent biodegradability: Zahn-Wellens/EMPA Test)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.9 (Biodegradation: Zahn-Wellens Test)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- 604-144-0
- EC Number:
- 604-144-0
- Cas Number:
- 139525-77-2
- Molecular formula:
- C13H15NO.HCl
- IUPAC Name:
- 604-144-0
- Test material form:
- solid: particulate/powder
- Details on test material:
- White powder
Constituent 1
- Specific details on test material used for the study:
- Batch : 839411/006Purity : 100.9%Expiry date : 10 Feb 2009Storage : room temperature (20 +/- 5°C), dry
Study design
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, domestic, adapted
- Details on inoculum:
- The sludge was taken from the activation basin of th ESN sewage treatment plant, Im Altenschemel, NW-Lachen-Speyerdord (date of collection : 8 nov 2007)The sludge was washed with tap water twice, then filtrated through a cloth and resuspended in test medium. It was then aerated. The dry matter was determined with 3960 mg suspended solids/L.
- Duration of test (contact time):
- ca. 28 d
Initial test substance concentration
- Initial conc.:
- ca. 200 mg/L
- Based on:
- DOC
Parameter followed for biodegradation estimation
- Parameter followed for biodegradation estimation:
- DOC removal
- Details on study design:
- Before sampling for DOC analysis, the pH was measured and adjusted, if necessary, evaporated water was replenished. From each flask; sample of 5 ml were taken on days 0.125 - 2 - 4 - 8 12 - 15 - 20 - 27 and 28. The samples were membrane filtrated and the DOC was measured.
Reference substance
- Reference substance:
- aniline
Results and discussion
- Test performance:
- All criteria were met : difference within replicates : 0,2% (target value <20%)Degradation of reference item : 7 days (target value < 14 days)Degradation in the toxicity control on day 14 : 42% (target value > 25%)
% Degradation
- Key result
- Parameter:
- % degradation (DOC removal)
- Value:
- ca. 2
- Sampling time:
- 28 d
- Details on results:
- As nearly no elimination or no degration occurend, no lag phase and no degradatio phase could be determined
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- not inherently biodegradable
- Conclusions:
- According the guideline 302B, Mephtamin HCL is not inherently biodegradable.
- Executive summary:
Mephtamin HCL was tested using a concentration of nominally 200 mg organic carbon/L in test medium following OECD 302B.
Aniline was chosen as reference item. Activated sludge from a sewage treating plant was used as inoculum (concentration 600 mg dry matter/L). The test was left running for 28 days.
To measure the degradation of test and Mephtamin HCL, the content of dissolved organic carbon (DOC) in the test vessels was measured nine times during the test.
All validity criteria were met. Degradation of the reference item was 98% after 8 days and of the Mephtamin at the end of the test is 2%
Therefore Mephtamin HCL is not inherently biodegradable.
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