1-Naphthaleneethanamine, 7-methoxy-, hydrochloride (1:1)

Density

Administrative data

Endpoint:

relative density

Type of information:

experimental study

Adequacy of study:

key study

Study period:

April 2016

Reliability:

1 (reliable without restriction)

Justification for type of information:

The determination was carried out using a gas comparison pycnometer and a procedure designed to be compatible with Method A.3 Relative Density of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 109 of the OECD Guidelines for Testing of Chemicals, 02 October 2012.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2016

Report date:

2016

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 109 (Density of Liquids and Solids)

GLP compliance:

yes (incl. QA statement)

Type of method:

pycnometer method

Test material

Test material information

Constituent 1

Reference substance name:

604-144-0

EC Number:

604-144-0

Cas Number:

139525-77-2

Molecular formula:

C13H15NO.HCl

IUPAC Name:

604-144-0

Test material form:

solid: particulate/powder

Details on test material:

White powder

Specific details on test material used for the study:

Batch Number : 18113833
Instrument : Gas comparison pycnometer (Multi-Pycnometer, Quantachrome, Syosset, N.Y., USA).
Calibration Sphere(s) : A stainless steel sphere with a calibrated known total volume (Vcal = 56.559 cm3).
Gas : Helium.
Conditions : All determinations were performed at 19.0 ± 1.0 °C.

Aliquots (see following table) of test item were weighed into the sample cell and placed into the pycnometer.
Determination 1 : 29.1415 g
Determination 2 : 27.3055 g

In triplicate, pressure readings (P1(sample) and P2(sample)) were taken after pressurizing the reference cell (Vref) and then switching to the sample cell (Vcell) for each determination.

Results and discussion

Density

Key result

Type:

relative density

Density:

ca. 1 230 kg/m³

Temp.:

19 °C

Any other information on results incl. tables

The pressure readings and the calculated volume for the reference and sample cells are shown in the joint document WK38GS).

As the reference cell volume and sample cell volume were within the defined tolerance (90.953 ± 1.0 cm3 and 149.225 ± 1.0 cm3 for the reference and sample cell volumes respectively) the gas comparison pycnometer was therefore considered acceptable for use.

Applicant's summary and conclusion

Conclusions:

Duplicate determinations were performed to ensure a reproducibility of less than ± 20 kg/m3 was obtained.
The mass density of a substance varies with temperature and pressure and this variance is typically negligible for solids. Increasing the temperature of a substance may decrease its density by increasing the volume of that substance. Typical thermal expansion coefficients of solids are in the order of 10-5 °C-1, and the volumetric expansion of stainless steel (used as calibration spheres) at 20 °C is approximately 5.2 x 10-5 °C-1. Therefore, a change in temperature of several degrees will have no significant effect on the volume and hence the density of a solid substance.
Therefore, it was considered that the difference in temperature between 20.0 °C and normal laboratory conditions did not have a significant

Executive summary:

The density of the test item has been determined to be 1.23 x 10E3 kg/m3 at 19.0 ± 1.0 °C;

relative density: 1.23.