Registration Dossier
Registration Dossier
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EC number: 616-749-7 | CAS number: 79869-59-3
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1976
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 976
- Report date:
- 1976
Materials and methods
- Principles of method if other than guideline:
- A single dose of the test substance dissolved in the appropriate vehicle was injected in to the peritoneal cavity of the test animals. After application, the animals were observed for mortality and clinical signs of toxicity. Animals that died during the experiment were necropsied. Surviving animals were sacrificed 14 days after application for the purpose of necropsy.
- GLP compliance:
- no
Test material
- Reference substance name:
- 3,10-bis(2-methylpropyl) perylene-3,10-dicarboxylate; 3,9-bis(2-methylpropyl) perylene-3,9-dicarboxylate
- EC Number:
- 616-749-7
- Cas Number:
- 79869-59-3
- Molecular formula:
- C30H28O4
- IUPAC Name:
- 3,10-bis(2-methylpropyl) perylene-3,10-dicarboxylate; 3,9-bis(2-methylpropyl) perylene-3,9-dicarboxylate
- Details on test material:
- - Analytical purity: 100%
- Name of test material (as cited in study report): Fluorolgruengold Misch. Nr. 27-3887
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- other: NMRI ivanovas
- Sex:
- male/female
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- CMC (carboxymethyl cellulose)
- Details on exposure:
- - Concentration in vehicle: 30% in 0.5% CMC
- Doses:
- 4640 and 6810 mg/kg
higher concentration could not be tested because of technical reasons - No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Necropsy of survivors performed: yes
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 6 810
- Remarks on result:
- other: No mortality occurred
- Mortality:
- 4640 mg/kg bw: 0/5 M, 0/5 F
6810 mg/kg bw: 0/5 M, 0/5 F - Clinical signs:
- Dyspnoe, apathy, spastic gait, tonic convulsions, poor general state of health
- Body weight:
- normal weight increase.
males: 26.0 g
females: 24.0 g - Gross pathology:
- intra amdominal residues of the test article
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
