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Diss Factsheets
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EC number: 201-969-4 | CAS number: 90-15-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Repeated dose toxicity: dermal
Administrative data
- Endpoint:
- sub-chronic toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- disregarded due to major methodological deficiencies
- Study period:
- 1976
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- significant methodological deficiencies
- Remarks:
- Major deficiences : unknow purity and specification of 1-naphthol (commercial product), no information on test animals and environmental conditions/ type of coverage/ observations. And there is only one concentration of exposition.
Data source
Reference
- Reference Type:
- publication
- Title:
- Teratology and Percutaneous Toxicity Studies on Hair Dyes
- Author:
- Burnett, C., Goldenthal, E. I., Harris, S. B., Wazeter, F. X., Strausberg, J., Kapp, R., and Voelker, R.
- Year:
- 1 976
- Bibliographic source:
- J. Toxicol. Environ. Health, 1: 1027-1040
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- - Principle of test: a hair dye formulation containing 1-naphthol was tested for systemic effects following application to groups of 12 New Zealand White Rabbits
- Short description of test conditions: 1-naphthol was tested by topical application twice weekly for 13 weeks to group of 12 New Zealand White Rabbits. - GLP compliance:
- no
Test material
- Reference substance name:
- 1-naphthol
- EC Number:
- 201-969-4
- EC Name:
- 1-naphthol
- Cas Number:
- 90-15-3
- Molecular formula:
- C10H8O
- IUPAC Name:
- naphthalen-1-ol
- Test material form:
- solid
- Details on test material:
- No data
Constituent 1
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: No data (commercial product)
- Expiration date of the lot/batch: No data
- Purity test date: No data
STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: No data
- Stability under test conditions: No data
- Solubility and stability of the test substance in the solvent/vehicle: No data
TREATMENT OF TEST MATERIAL PRIOR TO TESTING No
FORM AS APPLIED IN THE TEST Solution
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: No data
- Age at study initiation: No data
- Weight at study initiation: No data
- Housing: No data
- Diet (e.g. ad libitum): No data
- Water (e.g. ad libitum): No data
- Acclimation period: No data
DETAILS OF FOOD AND WATER QUALITY: No data
ENVIRONMENTAL CONDITIONS
- Temperature (°C): No data
- Humidity (%): No data
- Air changes (per hr): No data
- Photoperiod (hrs dark / hrs light):No data
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- other: 6% hydrogen peroxide
- Details on exposure:
- TEST SITE
- Area of exposure: thoracic-lumbar
- % coverage: No data
- Type of wrap if used: No (the rabbit were restrained in holding stocks)
- Time intervals for shavings or clipplings: the hair at the site of application on the back and sides of each rabbit was clipped short throughout the study
REMOVAL OF TEST SUBSTANCE
- Washing (if done): shampooed, rinsed, dried
- Time after start of exposure:1 hour
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 1 ml/kg
- Concentration (if solution): 0.25%
- Constant volume or concentration used: yes
- For solids, paste formed: no
VEHICLE
- Justification for use and choice of vehicle (if other than water): No data
- Amount(s) applied (volume or weight with unit): volume 1:1
- Concentration (if solution): 6%
- Lot/batch no. (if required): No data
- Purity: No data
USE OF RESTRAINERS FOR PREVENTING INGESTION: No data - Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- 13 weeks
- Frequency of treatment:
- Twice weekly
Doses / concentrations
- Dose / conc.:
- 0.5 other: %
- No. of animals per sex per dose:
- 12
- Control animals:
- yes, concurrent no treatment
- Details on study design:
- - Dose selection rationale: No data
- Positive control:
- No data
Examinations
- Observations and examinations performed and frequency:
- CAGE SIDE OBSERVATIONS: No data
DETAILED CLINICAL OBSERVATIONS: No data
DERMAL IRRITATION (if dermal study): No data
BODY WEIGHT: Yes
- Time schedule for examinations: weekly
FOOD CONSUMPTION: No data
FOOD EFFICIENCY:No data
WATER CONSUMPTION:No data
OPHTHALMOSCOPIC EXAMINATION: No data
HAEMATOLOGY: Yes
- Time schedule for collection of blood:0, 3, 7 and 13 weeks
- Anaesthetic used for blood collection: No data
- Animals fasted: No data
- How many animals:No data
- Parameters checked : blood count, methemoglobin, fasting blood sugar, blood urea nitrogen, alkaline phosphatase and serum glutamic oxaloacetic transminase.
CLINICAL CHEMISTRY: Yes
- Time schedule for collection of blood: 0, 3, 7 and 13 weeks
- Animals fasted: No data
- How many animals:No data
- Parameters checked :
URINALYSIS: Yes
- Time schedule for collection of urine: 0, 3, 7 and 13 weeks
- Metabolism cages used for collection of urine: No data
- Animals fasted:No data
- Parameters checked : color, pH, albumin, glucose, occult blood and microscopic elements
NEUROBEHAVIOURAL EXAMINATION: No data - Sacrifice and pathology:
- GROSS PATHOLOGY: Yes (organ-body weight ratios were determined for liver, kidneys, adrenals, heart, thyroid, spleen and brain)
HISTOPATHOLOGY: Yes (spleen, stomach, duodenum, colon, liver, gall, bladder, adrenals, nerve, eyes, pancreas, kidneys, urinary bladder, ovaries, testes, bone, bone marrow, hearth, lung, thyroid, brain and skeletal muscle) - Statistics:
- Analysis of variance F test and Student's test.
Results and discussion
Results of examinations
- Clinical signs:
- not examined
- Dermal irritation:
- not specified
- Mortality:
- not examined
- Body weight and weight changes:
- not examined
- Food consumption and compound intake (if feeding study):
- not specified
- Food efficiency:
- not specified
- Water consumption and compound intake (if drinking water study):
- not specified
- Ophthalmological findings:
- not specified
- Haematological findings:
- not examined
- Clinical biochemistry findings:
- not examined
- Urinalysis findings:
- not examined
- Behaviour (functional findings):
- not specified
- Immunological findings:
- not specified
- Organ weight findings including organ / body weight ratios:
- not examined
- Gross pathological findings:
- not examined
- Neuropathological findings:
- not specified
- Histopathological findings: neoplastic:
- not specified
- Other effects:
- not specified
Effect levels
- Dose descriptor:
- NOAEL
- Effect level:
- ca. 0.5 other: %
- Based on:
- test mat.
- Sex:
- male/female
Applicant's summary and conclusion
- Conclusions:
- Hair dye formulation containing 0.5% of 1 -naphthol was applied to rabbits twice weekly for 13 weeks. There was no evidence of systemic toxicity
- Executive summary:
Hair dye formulation containing 0.5% of 1 -naphthol was applied to rabbits twice weekly for 13 weeks. There was no evidence of systemic toxicity
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