Registration Dossier
Registration Dossier
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EC number: 204-516-9 | CAS number: 122-03-2
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1964
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 964
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Acute oral study. LD50 values were computed by the method of Litchfield & Wilcoxon (1949).
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 4-isopropylbenzaldehyde
- EC Number:
- 204-516-9
- EC Name:
- 4-isopropylbenzaldehyde
- Cas Number:
- 122-03-2
- Molecular formula:
- C10H12O
- IUPAC Name:
- 4-(propan-2-yl)benzaldehyde
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Osborne-Mendel
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- All doses given by intubation.
- Doses:
- 1000 and 2000
- No. of animals per sex per dose:
- 10 mice per dose.
- Control animals:
- no
- Details on study design:
- Groups of 10 rats were evenly divided by sex and fasted for approximately 18 hours prior to treatment.
Animals had access to water at all times and food was replaced in cages as soon as animals received their respective doses.
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 1 390 mg/kg bw
- Based on:
- test mat.
- Mortality:
- None indicated at 1000.
Deaths occured at 2000 mg/kg. - Clinical signs:
- other: Depression within 1hr after clinical treatment, scrawny appearance, porphyrin-like deposit around the eyes and nose.
- Gross pathology:
- Gross pathology showed discoloured liver, irritated gastro-intestinal tract, stomach haemorrhage, yellowish material attached to the intestines.
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- The LD50 is 1390 mg/kg.
- Executive summary:
The LD50 of Cuminic Aldehyde was determined to be 1390 mg/kg.
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