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Diss Factsheets
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EC number: 271-214-1 | CAS number: 68526-57-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable, well-documented study report which meets basic scientific principles: pre-GLP
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 962
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- 0.2 ml of test material was placed into the mouth of an anesthetized animal at which point the animal was stimulated to aspirate the material.
Test material
- Reference substance name:
- Decene
- EC Number:
- 246-870-7
- EC Name:
- Decene
- Cas Number:
- 25339-53-1
- IUPAC Name:
- dec-1-ene
- Details on test material:
- The olefins used in the study were hexene, octene, decene, dodecene, tetradecene, hexadecene, octadecene
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male
Administration / exposure
- Route of administration:
- other: aspiration
- Vehicle:
- unchanged (no vehicle)
- Doses:
- 0.2 ml
- No. of animals per sex per dose:
- 2 per dose
- Details on study design:
- Rats were anesthetized with ether, 0.2 ml of test material was placed into the mouth, and the animal was induced to aspirate the liquid by closing the nostrils with the thumb and forefinger during the inspiratory phase of the breathing cycle. After dosing, the animals were monitored for a minimum of 4 hours at intervals. Lungs were removed and examined as soon as possible after death. Twenty-four hours after dosing, survivors were euthanized and examined.
- Statistics:
- Not applicable
Results and discussion
- Mortality:
- Animals that aspirated hexene died within 2 minutes. All other compounds induced death within 1 hour of aspiration.
- Clinical signs:
- Not applicable
- Body weight:
- Not applicable
- Gross pathology:
- Some lungs were dark red.
Applicant's summary and conclusion
- Conclusions:
- The aspiration toxic potential of hexene, octene, decene, dodecene, tetradecene, hexadecene, and octadecene is 100%. This finding warrants the classification of higher olefins as aspiration hazards under EU GHS guidelines and warrants classification under the EU requirements for dangerous substances and preparations guidelines.
- Executive summary:
Hexene, octene, decene, dodecene, tetradecene, hexadecene, and octadecene were administered via induced aspiration to 2 male rats at a dose of 0.2 ml to assess the aspiration hazard. At the end of the study, except for hexene which induced death within 2 minutes of exposure, all other olefins tested induced death within 1 hour. This finding warrants the classification of higher olefins as aspiration hazards under EU GHS guidelines and warrants classification under the EU requirements for dangerous substances and preparations guidelines.
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