Resinoid of Ferula galbaniflua (Apiaceae) obtained from the exudate by hydrocarbon ester alcohol extraction.

Boiling point

Link to relevant study record(s)

Reference

Endpoint:

boiling point

Type of information:

experimental study

Adequacy of study:

key study

Study period:

29 November 2017 - 24 January 2018

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Justification for type of information:

The study was conducted according to an internationally recognised method, and under GLP. The test substance is adequately characterised. Therefore full validation applies.

Qualifier:

according to guideline

Guideline:

OECD Guideline 103 (Boiling Point)

Version / remarks:

1995

Deviations:

no

Qualifier:

according to guideline

Guideline:

EU Method A.2 (Boiling Temperature)

Version / remarks:

2008

Deviations:

no

Principles of method if other than guideline:

Not applicable

GLP compliance:

yes (incl. QA statement)

Remarks:

Inspected on 13 and 14 October 2014/ signed on 8 april 2015

Type of method:

method according to Siwoloboff

Key result

Boiling pt.:

197.9 °C

Atm. press.:

1 013 Pa

Decomposition:

no

Pre-test:

Observations	Temperatures
Individual small bubbles visible	130 °C
Individual bigger bubbles visible	200 °C
More big bubbles visible, the surface vibrate when bubbles rising up	210 °C
Bubble chain, gas burner switched off	230 °C
Bubble chain broke	215 °C
Less big bubbles visible	210 °C

After cooling down the test item appeared visually unchanged.

Main test:

The following values were recorded:

	Boiling Point
First determination	197.6 °C (470.8 K)
Second determination	197.3 °C (470.5 K)

In the first determination bubbles immediately occurred after setting the test tube into the aluminium block. A boiling chain was visible at 214.4 °C and the gas burner was switched off. Bubble chain broke at 197.6°C.

In the second determination bubbles were visible at 190.5 °C. A boiling chain was noted again at 214.5 °C and the gas burner was switched off. Bubble chain broke at 197.3°C.

After cooling down the test item appeared visually unchanged.

Results:

The boiling temperatures at standard pressure were calculated following the equation of Sidney-Young (only for small pressure deviations).

	Boiling point	Pressure in Pa	Corrected Boling point
First determination	197.6 °C (470.8 K)	100335 Pa	197.98 °C (471.13 K)
Second determination	197.3 °C (470.5 K)	100110 Pa	197.77 °C (470.92 K)
Mean			197.9 °C (471.0 K)

Mean ± standard deviation (after correction following Sydney Young) = 197.9 ± 0.2 °C (471.0 ± 0.2 K) at standard pressure (101.325 kPa).

Conclusions:

The boiling point was performed with the Siwoloboff method.
The boiling point of the test item was determined with 197.9 ± 0.2 °C (corresponding to 471.0 ± 0.2 K). This value is the mean of two independent determinations, corrected to standard pressure (101.325 kPa) using the Sidney-Young equation.
No observations were made which might cause doubts on the validity of the study outcome. Therefore, the result of the study is considered valid.

Executive summary:

The study was performed in order to determine the boiling point of test item according to OECD 103, resp. EU A.2, guideline, using the Siwoloboff method.

The boiling point of the test item was determined with 197.9 ± 0.2 °C (corresponding to 471.0 ± 0.2 K). This value is the mean of two independent determinations, corrected to standard pressure (101.325 kPa) using the Sidney-Young equation.

Description of key information

The boiling point of test item should be stated as: 197.9 ± 0.2 °C (corresponding to 471.0 ± 0.2 K).

Key value for chemical safety assessment

Boiling point at 101 325 Pa:

197.9 °C

Additional information

A fully reliable experimental study, conducted according to OECD 103/ EU A2 guideline is available.

It is considered as a key study, and the result is retained as key data.