Registration Dossier
Registration Dossier
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EC number: 206-662-9 | CAS number: 364-62-5
Endpoint summary
Administrative data
Description of key information
Two acute oral toxicity values are available, as secondary source, for metoclopramide:
mouse, LD50, oral = 270 mg/kg
rat, LD50, oral = 750 mg/kg.
Even if the LD50 for mouse trigger to the classification as Acute Tox. 3, as stated in CLP Regulation the preferred test species for evaluation of acute toxicity by the oral and inhalation routes is the rat. Therefore, the substance is classified as Acute Tox. 4 H302.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 750 mg/kg bw
- Based on:
- test mat.
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- Rat oral LD50 for metoclopramide is 750 mg/kg.
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 750 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Justification for classification or non-classification
Even if the oral LD50 for mouse trigger to the classification as Acute Tox. 3, as stated in CLP Regulation the preferred test species for evaluation of acute toxicity by the oral and inhalation routes is the rat. Therefore, the substance is classified as Acute Tox. 4 H302.
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