Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 246-874-9 | CAS number: 25340-17-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1957
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The study was performed before GLP. Limited information is available on study animals or test conditions.
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 957
- Report date:
- 1957
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Three male rats/dose level were exposed to saturated atmospheres of 1400 ppm (bath temperature-room temperature) or 2100 ppm (bath temperature- 100C).
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Diethylbenzene
- EC Number:
- 246-874-9
- EC Name:
- Diethylbenzene
- Cas Number:
- 25340-17-4
- Molecular formula:
- C10H14
- IUPAC Name:
- diethylbenzene
- Details on test material:
- IUCLID4 Test substance: other TS: Dowtherm J mixed isomers
Dowtherm J mixed isomers
Composition: 25% ortho, 40% meta and 35% Para
Boiling point: 180-184F at 760
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- No additional data
Administration / exposure
- Route of administration:
- inhalation
- Type of inhalation exposure:
- other: No data but typically whole body exposure for this teime period.
- Vehicle:
- not specified
- Details on inhalation exposure:
- No data
- Analytical verification of test atmosphere concentrations:
- no
- Duration of exposure:
- 7 h
- Concentrations:
- 1400 ppm(saturated vapors at room temperature) or 2100 ppm (saturated atmosphere at bath temperature of 100C)
- No. of animals per sex per dose:
- 3 male rats/dose
- Control animals:
- no
- Details on study design:
- No additional data
- Statistics:
- None
Results and discussion
- Preliminary study:
- Not applicable
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LC50
- Effect level:
- > 1 400 ppm
- Based on:
- test mat.
- Exp. duration:
- 7 h
- Remarks on result:
- other: Saturated atmosphere at room temprature. (Equivalent to >7800 mg/m3)
- Sex:
- male
- Dose descriptor:
- LC50
- Effect level:
- > 2 100 ppm
- Based on:
- test mat.
- Exp. duration:
- 7 h
- Remarks on result:
- other: Saturated atmosphere (100C bath)
- Mortality:
- All rats survived a seven hour (1400 ppm) exposure to saturated atmosphere of DEB mixed isomers generated at room temperature. All rats survived a seven hour (2100 ppm) exposure to saturated atmosphere of DEB mixed isomers generated at 100C bath temperature.
- Clinical signs:
- other: 1400 ppm- Very slight nasal irritation. Slightly drowsy on removal after exposure. 2100 ppm- Slight nasal irritation, drowsy on removal after exposure.
- Body weight:
- 1400 ppm- Slight to moderate weight loss
2100 ppm- Moderate weight loss, diarrhea - Gross pathology:
- 1400 ppm- Blue colors in all tissues and secretion, Slight kidney pathology, very slight liver in jury.
2100 ppm- All tissues and secretion were blue. Moderate kidney pathology, very slight liver injury.
Note: This blue color has been seen in rats exposed to vapors and rats which have been fed diethyl benzene. Whether the blue color is injurious or merely a cosmetic effect is not known. - Other findings:
- None
Any other information on results incl. tables
None
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- LC50>2100 ppm (saturated vapors) or > 11.52 mg/L for a 7 hour exposure in rats.
- Executive summary:
Groups of 3 male rats were exposed to 1400 ppm (saturated vapors at room temperature) or 2100 ppm (saturated atmosphere at bath temperature of 100C) for 7 hours.
The LC50 in rats following a 7 hour exposure of saturated atmosphere to rats was >2100 ppm or >11.52 mg/L.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.