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EC number: 265-499-1 | CAS number: 65138-66-1
Endpoint summary
Administrative data
Description of key information
Biodegradation in water
Biodegradability of 9-[2-(ethoxycarbonyl)phenyl]-3,6-bis(ethylamino)-2,7-dimethylxanthylium (CAS no. 65138 -66 -1) is predicted using OECD QSAR toolbox version 3.3 (2017) with logKow as the primary descriptor. Test substance undergoes 8.20% degradation by BOD in 28 days. Thus, based on percentage degradation, the test chemical 9 -[2 -(ethoxycarbonyl) phenyl]-3,6 -bis(ethylamino)-2,7 -dimethylxanthylium was estimated to be not readily biodegradable in water.
Additional information
Biodegradation in water
Predicted data for the target compound 9-[2-(ethoxycarbonyl)phenyl]-3,6-bis(ethylamino)-2,7-dimethylxanthylium (CAS No. 65138-66-1) and supporting weight of evidence studies for its closest read across substance with logKow as the primary descriptor were reviewed for the biodegradation end point which are summarized as below:
In a prediction done by SSS (2017) using OECD QSAR toolbox version 3.3 with logKow as the primary descriptor, percentage biodegradability of test chemical 9 -[2 -(ethoxy carbonyl)phenyl]-3,6 -bis(ethylamino)-2,7 -dimethylxanthylium(CAS No. 65138-66-1) was estimated.Test substance undergoes 8.20% degradation by BOD in 28 days. Thus, based on percentage degradation, the test chemical 9 -[2 -(ethoxycarbonyl) phenyl]-3,6 -bis(ethylamino)-2,7 -dimethylxanthylium was estimated to be not readily biodegradable in water.
In a supporting weight of evidence study from authoritative database (J-CHECK, 2016) for the read across chemical 3',6'-Bbis(diethylamino)spiro[isobenzofuran-1(3h),9'-[9h] xanthene]-3-one (CAS no. 509-34-2), biodegradation experiment was conducted for 28 days for evaluating the percentage biodegradability of read across substance 3',6'-Bbis(diethylamino)spiro[isobenzofuran-1(3h),9'-[9h] xanthene]-3-one. Concentration of inoculum i.e, sludge used was 30 mg/l and initial test substance conc. used in the study was 100 mg/l. The percentage degradation of read across substance 3',6'-Bbis(diethylamino)spiro[isobenzofuran-1(3h),9'-[9h]xanthene]-3-one was determined to be 0 and 1% degradation by BOD, TOC removal and HPLC in 28 days. Thus, based on percentage degradation, 3',6'-Bbis(diethylamino)spiro[isobenzofuran-1(3h),9'-[9h]xanthene]- 3 -one was considered to be not readily biodegradable in nature.
Another biodegradation study was conducted for 28 days for evaluating the percentage biodegradability of read across substance 9-(2-carboxyphenyl)-3,6-bis(diethylamino) xanthenium chloride (CAS no. 81-88-9) (J-CHECK, 2017) . Concentration of inoculum i.e, sludge was 30 mg/l and initial test substance conc. used in the study was 100 mg/l, respectively. The percentage degradation of substance 9-(2-carboxyphenyl)-3,6-bis(diethylamino)xanthenium chloride was determined to be 0, 2 and 7% degradation by BOD, TOC removal and Uv-Vis parameter in 28 days. Thus, based on percentage degradation, substance 9 -(2 -carboxyphenyl)-3,6 -bis(diethylamino)xanthenium chloride is considered to be not readily biodegradable in nature.
For the read across chemical 2 -[(2-cyanoethyl){4-[(4-nitrophenyl)diazenyl]phenyl}amino]ethyl benzoate (CAS no. 40690-89-9) from authoritative database (J-CHECK, 2017 and EnviChem, 2014), biodegradation study was conducted for 28 days for evaluating the percentage biodegradability of read across substance 2 -[(2 -cyanoethyl){4 -[(4 -nitrophenyl)diazenyl]phenyl}amino] ethyl benzoate. The study was performed according to OECD Guideline 301 C (Ready Biodegradability: Modified MITI Test (I)). Concentration of inoculum i.e, sludge used was 30 mg/l and initial test substance conc. used in the study was 100 mg/l, respectively. The percentage degradation of substance 2 -[(2 -cyanoethyl){4 -[(4 -nitrophenyl)diazenyl]phenyl}amino]ethyl benzoate was determined to be 6% by both BOD and HPLC parameter in 28 days. Thus, based on percentage degradation, 2 -[(2 -cyanoethyl){4 -[(4 -nitrophenyl)diazenyl]phenyl}amino]ethyl benzoate is considered to be not readily biodegradable in nature.
On the basis of above results for target chemical 9-[2-(ethoxycarbonyl)phenyl]-3,6-bis(ethylamino)-2,7-dimethylxanthylium (from OECD QSAR toolbox version 3.3, 2017) and for its read across substance (from authoritative database J-CHECK and EnviChem), it can be concluded that the test substance 9 -[2 -(ethoxycarbonyl)phenyl]-3,6 -bis(ethylamino)- 2,7 -dimethylxanthylium can be expected to be not readily biodegradable in nature.
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