Registration Dossier
Registration Dossier
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EC number: 219-440-1 | CAS number: 2437-25-4
Endpoint summary
Administrative data
Description of key information
Acute toxicity: Oral LD50 > 2,000 mg/kg for rat (LD50 limit test - no mortality)
Key value for chemical safety assessment
Additional information
Dodecanenitrile was evaluated for acute oral toxicity according to OECD 401 and EU 84/449/EEC B.1 guidelines in male and female Wistar rats in a limit test procedure. Animals were dosed with 2000 mg/kg bw of Dodecanenitrile as 20% solution in sesame oil. Symptoms of toxicity were observed, but no mortality occurred. Also comparable other nitriles as Coconitrile, Tallownitrile and Oleylnitrile showed no mortality up to highest tested dose of 5000 mg/kg body weight.
Justification for classification or non-classification
Only limited toxicity was observed after oral dosing of 2000 mg/kg, and hence no classification for acute oral toxicity is indicated.
Based on the very low water solubility and relative high Pow of 5, the rate of transfer to the epidermis is probably limited. However, the molecular size is not large and high Pow favours uptake in the stratum corneum. As worst case, 100% dermal absorption is assumed although in view of anticipated slow uptake into epidermis, systemic peak concentrations will be lower following acute dermal exposures compared to the oral route.
Dodecanenitrile is further mildly irritating to skin, and not irritating to the eyes, and consequently it is not expected to exert serious systemic toxicity by dermal or inhalation routes even when uptake is to be considered similar as following oral route.
Physical-chemical properties of Dodecanenitrile, being a liquid at room temperature with a relatively low vapour pressure (1.8 Pa at 20°C) and water solubility (ca. 25 mg/L), would also limit the likelihood of significant exposures by inhalation.
Consequently, Dodecanenitrile need not be classified for acute toxicity by dermal or respiratory route.
Alkylnitriles do not contain aliphatic, alicyclic and aromatic hydrocarbons. Also lack of surface activity (based on structure) indicates there is no aspiration hazard for Dodecanenitrile.
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