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Diss Factsheets
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EC number: 252-512-0 | CAS number: 35325-02-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation / corrosion, other
- Remarks:
- QSAR Toolbox gives a Qualitative prediction of skin irritation .
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Study period:
- 2017
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- accepted calculation method
- Justification for type of information:
- The QSAR Toolbox is a software intended to be used by governments, the chemical industry and other stakeholders to fill gaps in (eco-)toxicity data needed for assessing the hazards of chemicals. The Toolbox incorporates information and tools from various sources into a logical workflow.
Data source
Reference
- Reference Type:
- publication
- Title:
- QSAR toolbox version 2.3
- Author:
- Copyright 2012 Organisation for Economic Co-operation and Development & European Chemicals Agency
- Year:
- 2 012
- Bibliographic source:
- http://www.qsartoolbox.org/
Materials and methods
Test guideline
- Guideline:
- other: software program
Test material
- Reference substance name:
- N-(2-hydroxypropyl)benzenesulphonamide
- EC Number:
- 252-512-0
- EC Name:
- N-(2-hydroxypropyl)benzenesulphonamide
- Cas Number:
- 35325-02-1
- Molecular formula:
- C9H13NO3S
- IUPAC Name:
- N-(2-hydroxypropyl)benzenesulphonamide
- Test material form:
- liquid: viscous
Constituent 1
Results and discussion
In vitro
Results
- Irritation / corrosion parameter:
- other: READ across
- Remarks on result:
- no indication of irritation
Any other information on results incl. tables
Prediction approach: Read across among category members Experimental values for the target substance (if any) were not used in prediction calculations
- calculationn approach: Taking highest mode value from the 5 nearest neighbours
- descriptor: log Kow N-n(2-hydroxypropyl)benzenesulphonamide: 0.28 - 8 value(s) for 8 chemical(s)
- predicted value "skin irritation= negative" corresponds to "low" on the scale of "irritating and corrosive".
- uncertainty of prediction: Prediction confidence: P=1.26E-09 6 of 6 neighbours' data points have experimental value equal to prediction "Not irritating"
- The target chemical is classified as sulfone and arene by Organicfunctional groups. There has no alert being identified for the target in terms of protein binding by OASIS v1.2
endpoint | descriptor | chemical name | |
skin irritation | log kow | ||
Target chemical No | 0.280 | ||
Cat member No 1 | not irritating | 0.630 | |
Cat member No 2 | not irritating | -0.650 | |
Cat member No 3 | not irritating | -0.650 | |
Cat member No 4 | not irritating | -0.850 | |
Cat member No 5 | not corrosive | -2.02 | |
Cat member No 6 | not irritating | 2.73 | |
Cat member No 7 | cat 1B corrosive | -2.38 | |
Cat member No 8 | not irritating | -5.00 |
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results :negative
The negative result of the skin irritation found with the model skin irritation with the QSARtoolbox. - Executive summary:
QSAR toolbox was applied for the endpoint of skin irritation. . This information, will give the necessary information for the UICLID file, so no other tests will be acquired.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.