N-(2-hydroxypropyl)benzenesulphonamide

Biodegradation in water: screening tests

Link to relevant study record(s)

Reference

Endpoint:

biodegradation in water: ready biodegradability

Type of information:

(Q)SAR

Adequacy of study:

key study

Study period:

2103

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Acceptable well documented and validated QSAR

Justification for type of information:

BIOWIN iw an accepted and well validated SQAR prediction for biodegradation

Qualifier:

according to guideline

Guideline:

other: REACH guidance on QSARS R6 May 2008

Principles of method if other than guideline:

BIOWIN estimates the biodegradation of organic substances. The model is part of the EpiSuite program of the US-EPA. Estimations are made with BIOWIN version 4.10
In the BioWin program, the conclusion on Not ready biodegradation is estimated from two models.
• Biowin3 estimates complete ultimate biodegradation in a typical aquatic environment
• Biowin5 predicts biodegradability in the Japanese MITI i.e. OECD 301C test
BioWin gives a YES prediction for “Ready Biodegradation” if both of the following conditions are met:

• the ultimate biodegradation (Biowin3) results in weeks.
• MITI linear model (Biowin5) probability is < 0.5

Oxygen conditions:

aerobic

Duration of test (contact time):

ca. 28 d

Key result

Parameter:

calculated rating of total degradation time (QSAR/QSPR)

Remarks on result:

not readily biodegradable based on QSAR/QSPR prediction

Results with reference substance:

Validity of the model: see QMRF and QPRF

For the determination of the biodegradation in water a QSAR-system is used. The conclusion of BIOWIN is that N-(2-hydroxypropyl) benzene sulfonamide is estimated to be NOT readily biodegradable in a standard MITI test (OECD test guideline 301C)

Interpretation of results:

not readily biodegradable

Conclusions:

N-(2-hydroxypropyl) benzene sulfonamide is estimated to be not readily biodegradable in a standard MITI test (OECD 301C) by the BIOWIN QSAR model.

Executive summary:

The aerobic biodegradation of N-(2-hydroxypropyl) benzene sulfonamide was estimated by BIOWIN version 4.10.This QSAR model is included in the EPI Suite programs developed by Sycracuse Research Corporation for US-EPA. The conclusion of BIOWIN is that N-(2-hydroxypropyl) benzene sulfonamide is estimated to be not readily biodegradable in a standard MITI test (OECD test guideline 301C). The mineralisation is estimated to take weeks and the primary degradation occurs within a timeframe of days-weeks. Test results on biodegradation are not available. The calculated result can be used for classification and risk assessment.

Description of key information

N-(2-hydroxypropyl) benzene sulfonamide is estimated to be not readily biodegradable in a standard MITI test (OECD 301C) by the BIOWIN QSAR model.

Key value for chemical safety assessment

Biodegradation in water:

readily biodegradable but failing 10-day window