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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin irritation / corrosion

Currently viewing:

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
data is from peer reviewed journals

Data source

Reference
Reference Type:
publication
Title:
Safety Assessment of Xylene Sulfonic Acid, Toluene Sulfonic Acid, and Alkyl Aryl Sulfonate Hydrotropes as Used in Cosmetics
Author:
Bergfeld, Wilma F., Donald V. Belsito, Curtis D. Klaassen, Ronald Hill, Daniel Liebler, James G. Marks Jr, Ronald C. Shank, Thomas J. Slaga, Paul W. Snyder, and F. Alan Andersen.
Year:
2011
Bibliographic source:
International Journal of Toxicology, 30, no. 6_suppl (2011): 270S-283S

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: as mentioned below
Principles of method if other than guideline:
To assess the dermal irritation potential of sodium xylenesulphonate in rabbits
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Sodium xylenesulphonate
EC Number:
215-090-9
EC Name:
Sodium xylenesulphonate
Cas Number:
1300-72-7
Molecular formula:
C8H10O3S.Na
IUPAC Name:
sodium 3,4-dimethylbenzenesulfonate
Test material form:
solid
Details on test material:
IUPAC Name: Sodium xylenesulphonate
Common name: sodium xylenesulphonate
Mol. Formula: C24H27Na3O9S3
Mol. Weight: 208.2121 g/mol
Smiles notation: S(=O)(=O)(c1cc(c(cc1)C)C)[O-].[Na+]
InChIKey: QUCDWLYKDRVKMI-UHFFFAOYSA-M
Substance type: organic
Physical State: Solid
Specific details on test material used for the study:
IUPAC Name: Sodium xylenesulphonate
Common name: sodium xylenesulphonate
Mol. Formula: C24H27Na3O9S3
Mol. Weight: 208.2121 g/mol
Smiles notation: S(=O)(=O)(c1cc(c(cc1)C)C)[O-].[Na+]
InChIKey: QUCDWLYKDRVKMI-UHFFFAOYSA-M
Substance type: organic
Physical State: Solid

Test animals

Species:
rabbit
Strain:
not specified
Details on test animals or test system and environmental conditions:
no data available

Test system

Type of coverage:
not specified
Preparation of test site:
not specified
Vehicle:
water
Controls:
not specified
Amount / concentration applied:
0.5 ml of 40% aqueous solution of Sodium xylenesulphonate
Duration of treatment / exposure:
24 hours
Observation period:
24 hours
Number of animals:
no data available
Details on study design:
no data available

Results and discussion

In vitro

Other effects / acceptance of results:
no data available

In vivo

Results
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
24 h
Reversibility:
not specified
Remarks on result:
positive indication of irritation
Irritant / corrosive response data:
Slight irritation was observed
Other effects:
no data available

Applicant's summary and conclusion

Interpretation of results:
Category 2 (irritant) based on GHS criteria
Conclusions:
Slight irritation was observed in the rabbits.
Hence, Sodium xylenesulfonate can be considered to be slightly irritating to rabbit skin.
Executive summary:

The dermal irritation potential of Sodium xylenesulfonate was assessed in rabbits. 0.5 ml of 40% solution Sodium xylenesulfonate was applied to rabbit and observed for signs of irritation till 24 hours. Slight irritation was observed in the rabbits. Hence, Sodium xylenesulfonate can be considered to be slightly irritating to rabbit skin.