Registration Dossier
Registration Dossier
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EC number: 210-204-3 | CAS number: 609-99-4
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
- Remarks:
- Russian abstract
Data source
Reference
- Reference Type:
- publication
- Title:
- Toxicity of parahydroxybenzoic acid, 3,5-dinitrosalicylic acid, orthonitroanisole, 2-hydroxy-1-naphthaldehyde, copper 8-quinolinolate, polyester P2200, and dispersion dyes (miscible black ...), 1-nitro-2-carbonic acid, and 1-naphthylamine-5-sulfonic acid
- Author:
- Reznichenko, A. K. et al.
- Year:
- 1 986
- Bibliographic source:
- Gigiena i Sanitariya, (1986) No. 1, pp. 85-6
Materials and methods
- Principles of method if other than guideline:
- 1 treatment per day for 4 h at 10 consecutive days
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 3,5-dinitrosalicylic acid
- EC Number:
- 210-204-3
- EC Name:
- 3,5-dinitrosalicylic acid
- Cas Number:
- 609-99-4
- Molecular formula:
- C7H4N2O7
- IUPAC Name:
- 3,5-dinitrosalicylic acid
- Test material form:
- solid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
Test system
- Type of coverage:
- not specified
- Preparation of test site:
- not specified
- Vehicle:
- other: vegetable fat
- Remarks:
- 1:1
- Amount / concentration applied:
- 50 % in vegetable fat
- Duration of treatment / exposure:
- 10 x 4 h
Results and discussion
In vivo
Results
- Irritation parameter:
- other: signs of irritation
- Remarks on result:
- other: no signes of irritation
- Other effects:
- no absorption
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Remarks:
- The test item has not to be classified for skin irritation/corrosion according to Regulation (EC) No 1272/2008.
- Conclusions:
- not skin irritant
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