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EC number: 630-324-3 | CAS number: 861229-15-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 10 February 1992 - 9 March 1992
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 992
- Report date:
- 1992
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EPA OPP 81-1 (Acute Oral Toxicity)
- Version / remarks:
- EPA Pesticide Assessment Guidelines, Subdivision F, Hazard Evaluation:Human and Domestic Animals 81-1 Acute oral toxicity study (November 1984)
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 2-Ethylhexyl (R)-2-(2-methyl-4chlorophenoxy)propionate
- EC Number:
- 630-324-3
- Cas Number:
- 861229-15-4
- Molecular formula:
- C18H27ClO3
- IUPAC Name:
- 2-Ethylhexyl (R)-2-(2-methyl-4chlorophenoxy)propionate
Constituent 1
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- batch No.of test material: 5007
- sample No.:1505E
- Expiration date of the lot/batch: March 1993
STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: 4°C in the dark
Test animals
- Species:
- rat
- Strain:
- other: CD
- Remarks:
- of Sprague-Dawley origin (Hsd/Ola:Sprague-Dawley(CD))
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Harlan Olac Ltd., Bicester,Oxon,England
- Age at study initiation: 6 weeks
- Weight at study initiation: 140 to 160 g
- Fasting period before study: yes
- Housing: in groups of 5 rats of the same sex in metal cages with wire mesh floors
- Diet: ad libitum, Standard laboratory diet (Biosure LAD 1)
- Water: ad libitum
- Acclimation period: 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20-23°C
- Humidity (%): mean 58%
- Air changes (per hr): 10 to 15
- Photoperiod (hrs dark / hrs light): 12 hours/12 hours
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Doses:
- Preliminary study 800 mg/kg bw
Main study: 1000, 1260, 1600 mg/kg bw - No. of animals per sex per dose:
- Preliminary study: 2/sex/dose
Main study: 5/sex/dose - Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing:
body weight: recorded on Day 1 (prior dosing), 8 and 15 or at death
animals were observed for clinical signs soon after dosing and at frequent intervals for the remainder of Day 1 and subsequent twice a day
- Macroscopic examination; macroscopic appearance of all examined tissues recorded - Statistics:
- The acute median lethal oral dose (LD50) to rats was calculated using the method of Finney [FINNEY, D.J. (1971) Probit Analysis, 3rd ed., Cambridge University Press, Cambridge]. Separate LD50 values for males and females were estimated by undertaking probit analysis on the mortality data from the main study by fitting two parallel lines to the data (males only and females only) using the technique described by Finney [Finney, D.J. (1978) Statistical Method in Biological Assay, 3rd ed., Charles Griffin, London]. A chi-square test was carried out to check that the data did not contain any evidence of non-parallelism.
Results and discussion
- Preliminary study:
- The results of the preliminary study indicated that the acute lethal oral dose to rats of MCPP-p 2EHE was greater than 0.8 g/kg bw.
Effect levelsopen allclose all
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 1 400 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 1.2 - 1.6
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 1 300 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 1.1 - 1.6
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 1 400 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 1.2 - 1.9
- Mortality:
- There were deaths following a single dose of MCPP-P 2-EHE among rats of both sexes dosed at 1260 mg/kg bw and above. Death occurred at intervals from Day 2 until Day 5.
- Clinical signs:
- other: Piloerection was observed in all rats within 5 minutes of dosing and throughout the remainder of Day 1. This sign persisted and was accompanied on Day 1 and/or later intervals by: abnormal body carriage (hunched posture), lethargy, decreased respiratory r
- Gross pathology:
- No macroscopic abnormality was observed for animals killed on Day 15.
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- The oral LD50 for MCPP-P 2-EHE was 1400 mg/kg bw.
- Executive summary:
A GLP study according EPA Pesticide Assessment Guidelines, 81-1 acute oral toxicity (Revised Edition November 1984) on rats was performed to assess the acute oral toxicity of MCPP-P 2-EHE. Groups of 10 fasted rats (5 male/5 female) were administered a single oral dose by gavage of the test substance, as supplied, at dose levels of 1000, 1260 and 1600 mg/kg bw. There were deaths among male and female rats dosed at 1260 mg/kg bw and above from Day 2 until Day 5. Clinical signs of reaction to treatment included pilo-erection, abnormal body carriage (hunted posture), abnormal gait (waddling), lethargy, decreased respiratory rate, ptosis, pallor of the extremities, ataxia and prostration. Recovery of surviving rats, as judged by external appearance and behavior, was complete by Day 4 (1260 mg/kg bw), Day 3 or 5 (1000 mg/kg bw) or day 4 to 7 (1600 mg/kg bw). Small bodyweight gains were recorded on Day 8 for one male and one female dosed at 1600 mg/kg bw and one female dosed at 1000 mg/kg bw. All other surviving animals achieved satisfactory bodyweight gains throughout the study. No abnormalities were recorded at macroscopic examination at the end of the study. The LD50 (males/females) was 1400 mg/kg bw.
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