Registration Dossier
Registration Dossier
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EC number: 228-782-0 | CAS number: 6358-64-1
Partition coefficient
Administrative data
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- March 2008
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Recent OECD guideline study.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 008
- Report date:
- 2008
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
- Deviations:
- no
- GLP compliance:
- not specified
- Type of method:
- shake-flask method to: flask method
- Partition coefficient type:
- octanol-water
Test material
- Reference substance name:
- 4-chloro-2,5-dimethoxyaniline
- EC Number:
- 228-782-0
- EC Name:
- 4-chloro-2,5-dimethoxyaniline
- Cas Number:
- 6358-64-1
- Molecular formula:
- C8H10ClNO2
- IUPAC Name:
- 4-chloro-2,5-dimethoxyaniline
Constituent 1
Study design
- Analytical method:
- other: UV/VIS spectroscopy
Results and discussion
Partition coefficient
- Key result
- Type:
- log Pow
- Partition coefficient:
- 1.93
- Temp.:
- 23 °C
- pH:
- > 5 - < 6
Any other information on results incl. tables
Results in detail:
determ. no. |
stock solution
[ml] |
water
[ml] |
test substance conc. in n-octanol phase [mg/l] |
test substance conc. in water phase [mg/l] |
log Pow |
A1 |
10 |
20 |
601.7 |
7.3 |
1.92 |
A2 |
10 |
20 |
610.8 |
7.1 |
1.94 |
B1 |
20 |
20 |
611.3 |
7.1 |
1.93 |
B2 |
20 |
20 |
609.7 |
7.2 |
1.93 |
C1 |
40 |
20 |
610.4 |
7.3 |
1.92 |
C2 |
40 |
20 |
615.1 |
7.4 |
1.92 |
mean |
--- |
--- |
--- |
--- |
1.93 |
Recovery rate oft test substance:
determ. no. |
test substance in stock solution [mg] |
test substance in n-octanol phase [mg] |
test substance in water phase [mg] |
sum
[mg/l] |
recovery rate
[%] |
A1 |
6.36 |
6.02 |
0.15 |
6.16 |
97 |
A2 |
6.36 |
6.11 |
0.14 |
6.25 |
98 |
B1 |
12.72 |
12.23 |
0.14 |
12.37 |
97 |
B2 |
12.72 |
12.19 |
0.14 |
12.34 |
97 |
C1 |
25.44 |
24.42 |
0.15 |
24.56 |
97 |
C2 |
25.44 |
24.60 |
0.15 |
24.75 |
97 |
Applicant's summary and conclusion
- Conclusions:
- The partition coefficient (log Pow) of the test substance 4-choro-2,5-dimethoxyaniline (Lot DALC011945) was determined according to OECD Guideline for the Testing of Chemicals 107. The determined Log Pow was 1,93.
- Executive summary:
The partition coefficient (log Pow) of the test substance 4-choro-2,5-dimethoxyaniline (Lot DALC011945) was determined according to OECD Guideline for the Testing of Chemicals 107. The determined Log Pow was 1,93.
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