Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 228-667-5 | CAS number: 6320-03-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Ecotoxicological Summary
Administrative data
Hazard for aquatic organisms
Marine water
- Hazard assessment conclusion:
- PNEC aqua (marine water)
Hazard for air
Hazard for terrestrial organisms
Hazard for predators
Additional information
Short-term toxicity to aquatic invertebrates: Key study. Method according to OECD 202, GLP study. In accordance to range-finding preliminary studies, a semi-static study was performed (renewal period 24h); at nominal concentrations of 0.013, 0.032, 0.08, 0.2 and 0.5 mg/L test item.Twenty Daphnia magna (<24 h old, 5 per replicate) were exposed to either a control medium or the test item concentrations specified for 48 hours. The test concentrations were analytically determined at the start and at the end of the renewal periods by means of a validated method. All validity criteria were fulfilled. As the measured concentrations deviated more than 20 per cent from the nominal in most cases, biological results are based on the measured geometric mean test item concentrations: 0.004; 0.012; 0.039; 0.124 and 0.318 mg/L.
At concentrations of 0.124 mg/L test item or higher, 100% of the daphnia were immobilised after 48h, whereas none were immobilised at 0.039 mg/L test item. Based on the results obtained, the 48h EC50 value of the test item on Daphnia magna is 0.091 mg/L, and the 48h NOEC is 0.039 mg/L.
Short-term toxicity to aquatic algae and cyanobacteria: Key study. Method according to OECD 201, GLP study. Based on a range-finding study, Pseudokirchneriella subcapitata was exposed to 0 (control), 0.051, 0.128, 0.32, 0.8, 2.0 and 5.0 mg/L test item (nominal). Four replicates were performed per concentration and seven for the control. Growth was monitored daily by measuring the number of cells in each culture. Analytical monitoring was performed using a validated method at the start and at the end of the experiment. As the measured values differed more than 20% from the nominal values, biological results are based on the measured geometric mean test item concentrations: 0.031, 0.092, 0.190, 0.420; 1.005 and 2.502 mg/L. With respect to the inhibitory effect of the test item, the 0-72 h average specific growth rates were significantly different from that of the control group in the examined concentration range. The 72h EC50 of the test item on freshwater algae was found to be 0.401 mg/L, the NOEC is 0.092 mg/L and the LOEC 0.190 mg/L, based on growth rate (r).
Conclusion on classification
Based on the available information (72h-NOEC = 0.092 mg/L in algae, 48h-NOEC = 0.039 mg/L in daphnia), the substance is classified as Aquatic Acute 1 and Aquatic Chronic 1 according to CLP Regulation (EC) No. 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.