Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 205-160-7 | CAS number: 134-85-0
Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data for the target chemical is summarized based on the read across chemicals
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- WoE report is based on two hydrolysis studies as-
WoE 2 and WoE 3. - GLP compliance:
- not specified
- Radiolabelling:
- not specified
- Analytical monitoring:
- not specified
- Buffers:
- WoE 2 - pH: 7
WoE 3- pH: 3,5 - pH:
- 7
- Temp.:
- 25 °C
- Remarks:
- WoE 2
- pH:
- 3
- Temp.:
- 27 °C
- Remarks:
- WoE 3
- pH:
- 5
- Temp.:
- 27 °C
- Remarks:
- WoE 3
- Positive controls:
- not specified
- Negative controls:
- not specified
- Transformation products:
- not specified
- Key result
- pH:
- 7
- Temp.:
- 25 °C
- DT50:
- > 27 - < 120 yr
- Type:
- not specified
- Remarks on result:
- other: Test chemical was found to be stable in water at pH 3,5 and 7.
- Validity criteria fulfilled:
- not specified
- Conclusions:
- On the basis of the experimental studies of the structurally similar read across chemical and applying the weight of evidence, the half life DT50 value of test chemical was determined to be > 27 to < 120 years.
- Executive summary:
Data available of the structurally similar read across chemicals has been reviewed to determine the half life DT50 of the test chemical. The studies are as mentioned below:
The first study of hydrolysis in water was carried out. Test conditions includes pH of 7 and temperature of 25 °C. The half-life of DT50 value of test chemical was determined to be 27 years at pH 7 and 25 °C. As per the value of DT50 the test chemical was considered to be stable in water.
The second study of hydrolysis in water was carried out. Test conditions includes pH of 3,5 and temperature of 27 °C. The half-life of DT50 value of test chemical was determined to be 120 years at pH 3,5 and 27 °C. As per the value of DT50 the test chemical was considered to be stable in water.
On the basis of the experimental studies of the structurally similar read across chemical and applying the weight of evidence, the half life DT50 value of test chemical was determined to be > 27 to < 120 years. As per the value of DT50 the test chemical was considered to be stable in water.
Reference
Description of key information
On the basis of the experimental studies of the structurally similar read across chemical and applying the weight of evidence, the half life DT50 value of test chemical was determined to be > 27 to < 120 years.
Key value for chemical safety assessment
- Half-life for hydrolysis:
- 27 yr
- at the temperature of:
- 25 °C
Additional information
Data available of the structurally similar read across chemicals has been reviewed to determine the half life DT50 of the test chemical. The studies are as mentioned below:
The first study of hydrolysis in water was carried out. Test conditions includes pH of 7 and temperature of 25 °C. The half-life of DT50 value of test chemical was determined to be 27 years at pH 7 and 25 °C. As per the value of DT50 the test chemical was considered to be stable in water.
The second study of hydrolysis in water was carried out. Test conditions includes pH of 3,5 and temperature of 27 °C. The half-life of DT50 value of test chemical was determined to be 120 years at pH 3,5 and 27 °C. As per the value of DT50 the test chemical was considered to be stable in water.
On the basis of the experimental studies of the structurally similar read across chemical and applying the weight of evidence, the half life DT50 value of test chemical was determined to be > 27 to < 120 years. As per the value of DT50 the test chemical was considered to be stable in water.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
