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EC number: 219-264-5 | CAS number: 2398-37-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: screening tests
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with limited documentation / justification
- Justification for type of information:
- The supporting QMRF report has been attached
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 301 C (Ready Biodegradability: Modified MITI Test (I))
- Principles of method if other than guideline:
- The data is predicted using the OECD QSAR toolbox version 3.3 with logKow as the primary descriptor.
- GLP compliance:
- not specified
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): 1-bromo-3-methoxybenzene
- Molecular formula (if other than submission substance): C7H7BrO
- Molecular weight (if other than submission substance): 187.035 g/mol
- Smiles notation (if other than submission substance): c1(cc(ccc1)Br)OC
- InChI: 1S/C7H7BrO/c1-9-7-4-2-3-6(8)5-7/h2-5H,1H3
- Substance type: Organic
- Physical state: Liquid - Oxygen conditions:
- aerobic
- Inoculum or test system:
- other: Microorganisms
- Duration of test (contact time):
- 28 d
- Parameter followed for biodegradation estimation:
- other: BOD
- Key result
- Parameter:
- other: BOD
- Value:
- 0.125
- Sampling time:
- 28 d
- Remarks on result:
- other: Other details not known
- Details on results:
- Test substance undergoes 0.125% degradation by BOD in 28 days.
- Validity criteria fulfilled:
- not specified
- Interpretation of results:
- not readily biodegradable
- Conclusions:
- The test chemical 1-Bromo-3-methoxybenzene was estimated to be not readily biodegradable in water.
- Executive summary:
Biodegradability of 1 -Bromo-3 -methoxybenzene (CAS no. 2398 -37 -0) is predicted using QSAR toolbox version 3.3. Test substance undergoes 0.125% degradation by BOD in 28 days. Thus, based on percentage degradation, the test chemical 1 -Bromo-3 -methoxybenzene was estimated to be not readily biodegradable in water.
Reference
The
prediction was based on dataset comprised from the following
descriptors: BOD
Estimation method: Takes average value from the 6 nearest neighbours
Domain logical expression:Result: In Domain
((((((("a"
or "b" or "c" or "d" or "e" )
and ("f"
and (
not "g")
)
)
and (("h"
or "i" or "j" or "k" or "l" )
and ("m"
and (
not "n")
)
)
and (("o"
or "p" or "q" or "r" or "s" )
and ("t"
and (
not "u")
)
)
and (("v"
or "w" or "x" or "y" or "z" )
and ("aa"
and (
not "ab")
)
)
and (("ac"
or "ad" or "ae" or "af" or "ag" )
and ("ah"
and (
not "ai")
)
)
)
and "aj" )
and "ak" )
and "al" )
and ("am"
and "an" )
)
Domain
logical expression index: "a"
Referential
boundary: The
target chemical should be classified as Neutral Organics by US-EPA New
Chemical Categories
Domain
logical expression index: "b"
Referential
boundary: The
target chemical should be classified as Aryl AND Aryl halide AND Ether
by Organic Functional groups
Domain
logical expression index: "c"
Referential
boundary: The
target chemical should be classified as Aryl halide AND Ether AND
Overlapping groups by Organic Functional groups (nested)
Domain
logical expression index: "d"
Referential
boundary: The
target chemical should be classified as Aliphatic Carbon [CH] AND
Aliphatic Carbon [-CH2-] AND Aliphatic Carbon [-CH3] AND Aromatic Carbon
[C] AND Bromine, aromatic attach [-Br] AND Bromine, olefinic attach
[-Br] AND Olefinic carbon [=CH- or =C<] AND Oxygen, one aromatic attach
[-O-] by Organic functional groups (US EPA)
Domain
logical expression index: "e"
Referential
boundary: The
target chemical should be classified as Alkylarylether AND Aromatic
compound AND Aryl bromide AND Aryl halide AND Ether AND Halogen
derivative by Organic functional groups, Norbert Haider (checkmol)
Domain
logical expression index: "f"
Referential
boundary: The
target chemical should be classified as No alert found by DNA binding by
OASIS v.1.3
Domain
logical expression index: "g"
Referential
boundary: The
target chemical should be classified as AN2 OR AN2 >> Michael-type
addition, quinoid structures OR AN2 >> Michael-type addition, quinoid
structures >> Flavonoids OR AN2 >> Michael-type addition, quinoid
structures >> Quinoneimines OR AN2 >> Michael-type addition, quinoid
structures >> Quinones OR AN2 >> Carbamoylation after isocyanate
formation OR AN2 >> Carbamoylation after isocyanate formation >>
Hydroxamic Acids OR AN2 >> Carbamoylation after isocyanate formation >>
N-Hydroxylamines OR AN2 >> Michael-type addition on alpha,
beta-unsaturated carbonyl compounds OR AN2 >> Michael-type addition on
alpha, beta-unsaturated carbonyl compounds >> Four- and Five-Membered
Lactones OR AN2 >> Schiff base formation OR AN2 >> Schiff base formation
>> Dicarbonyl compounds OR AN2 >> Schiff base formation >> Halofuranones
OR AN2 >> Schiff base formation >> Polarized Haloalkene Derivatives OR
AN2 >> Schiff base formation by aldehyde formed after metabolic
activation OR AN2 >> Schiff base formation by aldehyde formed after
metabolic activation >> Geminal Polyhaloalkane Derivatives OR AN2 >>
Schiff base formation by aldehyde formed after metabolic activation >>
N-methylol derivatives OR AN2 >> Shiff base formation after aldehyde
release OR AN2 >> Shiff base formation after aldehyde release >>
Specific Acetate Esters OR AN2 >> Shiff base formation for aldehydes OR
AN2 >> Shiff base formation for aldehydes >> Geminal Polyhaloalkane
Derivatives OR AN2 >> Thioacylation via nucleophilic addition after
cysteine-mediated thioketene formation OR AN2 >> Thioacylation via
nucleophilic addition after cysteine-mediated thioketene formation >>
Haloalkenes with Electron-Withdrawing Groups OR AN2 >> Thioacylation via
nucleophilic addition after cysteine-mediated thioketene formation >>
Polarized Haloalkene Derivatives OR Non-covalent interaction OR
Non-covalent interaction >> DNA intercalation OR Non-covalent
interaction >> DNA intercalation >> Acridone, Thioxanthone, Xanthone and
Phenazine Derivatives OR Non-covalent interaction >> DNA intercalation
>> Amino Anthraquinones OR Non-covalent interaction >> DNA intercalation
>> Aminoacridine DNA Intercalators OR Non-covalent interaction >> DNA
intercalation >> Coumarins OR Non-covalent interaction >> DNA
intercalation >> DNA Intercalators with Carboxamide Side Chain OR
Non-covalent interaction >> DNA intercalation >> Fused-Ring
Nitroaromatics OR Non-covalent interaction >> DNA intercalation >>
Fused-Ring Primary Aromatic Amines OR Non-covalent interaction >> DNA
intercalation >> Quinones OR Non-specific OR Non-specific >>
Incorporation into DNA/RNA, due to structural analogy with nucleoside
bases OR Non-specific >> Incorporation into DNA/RNA, due to
structural analogy with nucleoside bases >> Specific Imine and
Thione Derivatives OR Radical OR Radical >> Generation of reactive
oxygen species OR Radical >> Generation of reactive oxygen species >>
Thiols OR Radical >> Generation of ROS by glutathione depletion
(indirect) OR Radical >> Generation of ROS by glutathione depletion
(indirect) >> Haloalkanes Containing Heteroatom OR Radical >> Radical
attack after one-electron reduction of diazonium cation OR Radical >>
Radical attack after one-electron reduction of diazonium cation >>
Arenediazonium Salts OR Radical >> Radical mechanism by ROS formation OR
Radical >> Radical mechanism by ROS formation (indirect) or direct
radical attack on DNA OR Radical >> Radical mechanism by ROS formation
(indirect) or direct radical attack on DNA >> Organic Peroxy Compounds
OR Radical >> Radical mechanism by ROS formation >> Acridone,
Thioxanthone, Xanthone and Phenazine Derivatives OR Radical >> Radical
mechanism via ROS formation (indirect) OR Radical >> Radical mechanism
via ROS formation (indirect) >> Amino Anthraquinones OR Radical >>
Radical mechanism via ROS formation (indirect) >> Anthrones OR Radical
>> Radical mechanism via ROS formation (indirect) >> C-Nitroso Compounds
OR Radical >> Radical mechanism via ROS formation (indirect) >>
Conjugated Nitro Compounds OR Radical >> Radical mechanism via ROS
formation (indirect) >> Coumarins OR Radical >> Radical mechanism via
ROS formation (indirect) >> Flavonoids OR Radical >> Radical mechanism
via ROS formation (indirect) >> Fused-Ring Nitroaromatics OR Radical >>
Radical mechanism via ROS formation (indirect) >> Fused-Ring Primary
Aromatic Amines OR Radical >> Radical mechanism via ROS formation
(indirect) >> Geminal Polyhaloalkane Derivatives OR Radical >> Radical
mechanism via ROS formation (indirect) >> Haloalcohols OR Radical >>
Radical mechanism via ROS formation (indirect) >> Hydrazine Derivatives
OR Radical >> Radical mechanism via ROS formation (indirect) >>
N-Hydroxylamines OR Radical >> Radical mechanism via ROS formation
(indirect) >> Nitro Azoarenes OR Radical >> Radical mechanism via ROS
formation (indirect) >> Nitroaniline Derivatives OR Radical >> Radical
mechanism via ROS formation (indirect) >> Nitroarenes with Other Active
Groups OR Radical >> Radical mechanism via ROS formation (indirect) >>
Nitrophenols, Nitrophenyl Ethers and Nitrobenzoic Acids OR Radical >>
Radical mechanism via ROS formation (indirect) >> p-Substituted
Mononitrobenzenes OR Radical >> Radical mechanism via ROS formation
(indirect) >> Quinones OR Radical >> Radical mechanism via ROS formation
(indirect) >> Specific Imine and Thione Derivatives OR Radical >> ROS
formation after GSH depletion (indirect) OR Radical >> ROS formation
after GSH depletion (indirect) >> Quinoneimines OR SN1 OR SN1 >>
Alkylation after metabolically formed carbenium ion species OR SN1 >>
Alkylation after metabolically formed carbenium ion species >>
Polycyclic Aromatic Hydrocarbon Derivatives OR SN1 >> Carbenium ion
formation OR SN1 >> Carbenium ion formation >> Alpha-Haloethers OR SN1
>> DNA bases alkylation by carbenium ion formed OR SN1 >> DNA bases
alkylation by carbenium ion formed >> Diazoalkanes OR SN1 >>
Nucleophilic attack after carbenium ion formation OR SN1 >> Nucleophilic
attack after carbenium ion formation >> N-Nitroso Compounds OR SN1 >>
Nucleophilic attack after carbenium ion formation >> Pyrrolizidine
Derivatives OR SN1 >> Nucleophilic attack after carbenium ion formation
>> Specific Acetate Esters OR SN1 >> Nucleophilic attack after diazonium
or carbenium ion formation OR SN1 >> Nucleophilic attack after diazonium
or carbenium ion formation >> Nitroarenes with Other Active Groups OR
SN1 >> Nucleophilic attack after metabolic nitrenium ion formation OR
SN1 >> Nucleophilic attack after metabolic nitrenium ion formation >>
Amino Anthraquinones OR SN1 >> Nucleophilic attack after metabolic
nitrenium ion formation >> Fused-Ring Primary Aromatic Amines OR SN1 >>
Nucleophilic attack after metabolic nitrenium ion formation >>
N-Hydroxylamines OR SN1 >> Nucleophilic attack after nitrenium and/or
carbenium ion formation OR SN1 >> Nucleophilic attack after nitrenium
and/or carbenium ion formation >> N-Nitroso Compounds OR SN1 >>
Nucleophilic attack after reduction and nitrenium ion formation OR SN1
>> Nucleophilic attack after reduction and nitrenium ion formation >>
Conjugated Nitro Compounds OR SN1 >> Nucleophilic attack after reduction
and nitrenium ion formation >> Fused-Ring Nitroaromatics OR SN1 >>
Nucleophilic attack after reduction and nitrenium ion formation >> Nitro
Azoarenes OR SN1 >> Nucleophilic attack after reduction and nitrenium
ion formation >> Nitroaniline Derivatives OR SN1 >> Nucleophilic attack
after reduction and nitrenium ion formation >> Nitroarenes with Other
Active Groups OR SN1 >> Nucleophilic attack after reduction and
nitrenium ion formation >> Nitrobiphenyls and Bridged Nitrobiphenyls OR
SN1 >> Nucleophilic attack after reduction and nitrenium ion formation
>> Nitrophenols, Nitrophenyl Ethers and Nitrobenzoic Acids OR SN1 >>
Nucleophilic attack after reduction and nitrenium ion formation >>
p-Substituted Mononitrobenzenes OR SN1 >> Nucleophilic substitution
after glutathione-induced nitrenium ion formation OR SN1 >> Nucleophilic
substitution after glutathione-induced nitrenium ion formation >>
C-Nitroso Compounds OR SN1 >> Nucleophilic substitution on diazonium
ions OR SN1 >> Nucleophilic substitution on diazonium ions >> Specific
Imine and Thione Derivatives OR SN1 >> SN1 reaction at nitrogen-atom
bound to a good leaving group or on nitrenium ion OR SN1 >> SN1
reaction at nitrogen-atom bound to a good leaving group or on nitrenium
ion >> N-Acyloxy(Alkoxy) Arenamides OR SN2 OR SN2 >> Acylation OR SN2 >>
Acylation >> Hydroxamic Acids OR SN2 >> Acylation >> Specific Acetate
Esters OR SN2 >> Acylation involving a leaving group OR SN2 >>
Acylation involving a leaving group >> Geminal Polyhaloalkane
Derivatives OR SN2 >> Acylation involving a leaving group after
metabolic activation OR SN2 >> Acylation involving a leaving group after
metabolic activation >> Geminal Polyhaloalkane Derivatives OR SN2 >>
Alkylation by epoxide metabolically formed after E2 reaction OR SN2 >>
Alkylation by epoxide metabolically formed after E2 reaction >>
Haloalcohols OR SN2 >> Alkylation by epoxide metabolically formed after
E2 reaction >> Monohaloalkanes OR SN2 >> Alkylation, direct acting
epoxides and related OR SN2 >> Alkylation, direct acting epoxides and
related >> Epoxides and Aziridines OR SN2 >> Alkylation, direct acting
epoxides and related after cyclization OR SN2 >> Alkylation, direct
acting epoxides and related after cyclization >> Nitrogen Mustards OR
SN2 >> Alkylation, direct acting epoxides and related after
P450-mediated metabolic activation OR SN2 >> Alkylation, direct acting
epoxides and related after P450-mediated metabolic activation >>
Haloalkenes with Electron-Withdrawing Groups OR SN2 >> Alkylation,
direct acting epoxides and related after P450-mediated metabolic
activation >> Polycyclic Aromatic Hydrocarbon Derivatives OR SN2 >>
Alkylation, nucleophilic substitution at sp3-carbon atom OR SN2 >>
Alkylation, nucleophilic substitution at sp3-carbon atom >>
Monohaloalkanes OR SN2 >> Alkylation, nucleophilic substitution at
sp3-carbon atom >> Sulfonates and Sulfates OR SN2 >> Alkylation, ring
opening SN2 reaction OR SN2 >> Alkylation, ring opening SN2 reaction >>
Four- and Five-Membered Lactones OR SN2 >> Direct acting epoxides formed
after metabolic activation OR SN2 >> Direct acting epoxides formed after
metabolic activation >> Coumarins OR SN2 >> Direct acting epoxides
formed after metabolic activation >> Quinoline Derivatives OR SN2 >>
Direct nucleophilic attack on diazonium cation OR SN2 >> Direct
nucleophilic attack on diazonium cation >> Arenediazonium Salts OR SN2
>> DNA alkylation OR SN2 >> DNA alkylation >> Alkylphosphates,
Alkylthiophosphates and Alkylphosphonates OR SN2 >> DNA alkylation >>
Vicinal Dihaloalkanes OR SN2 >> Internal SN2 reaction with aziridinium
and/or cyclic sulfonium ion formation (enzymatic) OR SN2 >> Internal SN2
reaction with aziridinium and/or cyclic sulfonium ion formation
(enzymatic) >> Vicinal Dihaloalkanes OR SN2 >> Nucleophilic substitution
after carbenium ion formation OR SN2 >> Nucleophilic substitution after
carbenium ion formation >> Monohaloalkanes OR SN2 >> Nucleophilic
substitution at sp3 Carbon atom OR SN2 >> Nucleophilic substitution at
sp3 Carbon atom >> Haloalkanes Containing Heteroatom OR SN2 >>
Nucleophilic substitution at sp3 Carbon atom >> Halofuranones OR SN2 >>
Nucleophilic substitution at sp3 Carbon atom >> Specific Acetate Esters
OR SN2 >> Nucleophilic substitution at sp3 carbon atom after thiol
(glutathione) conjugation OR SN2 >> Nucleophilic substitution at sp3
carbon atom after thiol (glutathione) conjugation >> Geminal
Polyhaloalkane Derivatives OR SN2 >> SN2 at an activated carbon atom OR
SN2 >> SN2 at an activated carbon atom >> Quinoline Derivatives OR SN2
>> SN2 at Nitrogen Atom OR SN2 >> SN2 at Nitrogen Atom >>
N-acetoxyamines OR SN2 >> SN2 at sp3 and activated sp2 carbon atom OR
SN2 >> SN2 at sp3 and activated sp2 carbon atom >> Polarized Haloalkene
Derivatives OR SN2 >> SN2 at sp3-carbon atom OR SN2 >> SN2 at sp3-carbon
atom >> Alpha-Haloethers OR SN2 >> SN2 at sulfur atom OR SN2 >> SN2 at
sulfur atom >> Sulfonyl Halides OR SN2 >> SN2 attack on activated carbon
Csp3 or Csp2 OR SN2 >> SN2 attack on activated carbon Csp3 or Csp2 >>
Nitroarenes with Other Active Groups OR SN2 >> SN2 reaction at
nitrogen-atom bound to a good leaving group OR SN2 >> SN2 reaction at
nitrogen-atom bound to a good leaving group >> N-Acetoxyamines OR SN2 >>
SN2 reaction at nitrogen-atom bound to a good leaving group or nitrenium
ion OR SN2 >> SN2 reaction at nitrogen-atom bound to a good leaving
group or nitrenium ion >> N-Acyloxy(Alkoxy) Arenamides by DNA binding by
OASIS v.1.3
Domain
logical expression index: "h"
Referential
boundary: The
target chemical should be classified as Neutral Organics by US-EPA New
Chemical Categories
Domain
logical expression index: "i"
Referential
boundary: The
target chemical should be classified as Aryl AND Aryl halide AND Ether
by Organic Functional groups
Domain
logical expression index: "j"
Referential
boundary: The
target chemical should be classified as Aryl halide AND Ether AND
Overlapping groups by Organic Functional groups (nested)
Domain
logical expression index: "k"
Referential
boundary: The
target chemical should be classified as Aliphatic Carbon [CH] AND
Aliphatic Carbon [-CH2-] AND Aliphatic Carbon [-CH3] AND Aromatic Carbon
[C] AND Bromine, aromatic attach [-Br] AND Bromine, olefinic attach
[-Br] AND Olefinic carbon [=CH- or =C<] AND Oxygen, one aromatic attach
[-O-] by Organic functional groups (US EPA)
Domain
logical expression index: "l"
Referential
boundary: The
target chemical should be classified as Alkylarylether AND Aromatic
compound AND Aryl bromide AND Aryl halide AND Ether AND Halogen
derivative by Organic functional groups, Norbert Haider (checkmol)
Domain
logical expression index: "m"
Referential
boundary: The
target chemical should be classified as No alert found by DNA binding by
OECD
Domain
logical expression index: "n"
Referential
boundary: The
target chemical should be classified as Acylation OR Acylation >> Direct
Addition of an Acyl Halide OR Acylation >> Direct Addition of an Acyl
Halide >> Acyl halide OR Acylation >> Isocyanates and Isothiocyanates OR
Acylation >> Isocyanates and Isothiocyanates >> Isocyanates OR Acylation
>> Isocyanates and Isothiocyanates >> Isothiocyanates OR Acylation >>
P450 Mediated Activation to Acyl Halides OR Acylation >> P450 Mediated
Activation to Acyl Halides >> 1,1-Dihaloalkanes OR Acylation >> P450
Mediated Activation to Isocyanates or Isothiocyanates OR Acylation >>
P450 Mediated Activation to Isocyanates or Isothiocyanates >>
Benzylamines-Acylation OR Acylation >> P450 Mediated Activation to
Isocyanates or Isothiocyanates >> Formamides OR Acylation >> P450
Mediated Activation to Isocyanates or Isothiocyanates >> Sulfonylureas
OR Acylation >> P450 Mediated Activation to Isocyanates or
Isothiocyanates >> Thioureas OR Michael addition OR Michael addition >>
P450 Mediated Activation of Heterocyclic Ring Systems OR Michael
addition >> P450 Mediated Activation of Heterocyclic Ring Systems >>
Furans OR Michael addition >> P450 Mediated Activation of Heterocyclic
Ring Systems >> Thiophenes-Michael addition OR Michael addition >> P450
Mediated Activation to Quinones and Quinone-type Chemicals OR Michael
addition >> P450 Mediated Activation to Quinones and Quinone-type
Chemicals >> 5-alkoxyindoles OR Michael addition >> P450 Mediated
Activation to Quinones and Quinone-type Chemicals >> Alkyl phenols OR
Michael addition >> P450 Mediated Activation to Quinones and
Quinone-type Chemicals >> Arenes OR Michael addition >> P450 Mediated
Activation to Quinones and Quinone-type Chemicals >> Hydroquinones OR
Michael addition >> P450 Mediated Activation to Quinones and
Quinone-type Chemicals >> Methylenedioxyphenyl OR Michael addition >>
P450 Mediated Activation to Quinones and Quinone-type Chemicals >>
Polycyclic (PAHs) and heterocyclic (HACs) aromatic hydrocarbons-Michael
addition OR Michael addition >> Polarised Alkenes-Michael addition OR
Michael addition >> Polarised Alkenes-Michael addition >> Alpha, beta-
unsaturated amides OR Michael addition >> Polarised Alkenes-Michael
addition >> Alpha, beta- unsaturated ketones OR Michael addition >>
Quinones and Quinone-type Chemicals OR Michael addition >> Quinones and
Quinone-type Chemicals >> Quinone-imines OR Michael addition >> Quinones
and Quinone-type Chemicals >> Quinones OR Schiff base formers OR Schiff
base formers >> Chemicals Activated by P450 to Glyoxal OR Schiff base
formers >> Chemicals Activated by P450 to Glyoxal >> Ethanolamines
(including morpholine) OR Schiff base formers >> Chemicals Activated by
P450 to Mono-aldehydes OR Schiff base formers >> Chemicals Activated by
P450 to Mono-aldehydes >> Benzylamines-Schiff base OR Schiff base
formers >> Chemicals Activated by P450 to Mono-aldehydes >> N-methylol
derivates OR Schiff base formers >> Chemicals Activated by P450 to
Mono-aldehydes >> Thiazoles OR Schiff base formers >> Direct Acting
Schiff Base Formers OR Schiff base formers >> Direct Acting Schiff Base
Formers >> Alpha-beta-dicarbonyl OR Schiff base formers >> Direct Acting
Schiff Base Formers >> Mono aldehydes OR SN1 OR SN1 >> Carbenium Ion
Formation OR SN1 >> Carbenium Ion Formation >> Allyl benzenes OR SN1 >>
Carbenium Ion Formation >> Alpha halo ethers (including alpha halo
thioethers) OR SN1 >> Carbenium Ion Formation >> Diazoalkanes OR SN1 >>
Carbenium Ion Formation >> N-Nitroso (alkylation) OR SN1 >> Carbenium
Ion Formation >> Polycyclic (PAHs) and heterocyclic (HACs) aromatic
hydrocarbons-SN1 OR SN1 >> Iminium Ion Formation OR SN1 >> Iminium Ion
Formation >> Aliphatic tertiary amines OR SN1 >> Nitrenium Ion formation
OR SN1 >> Nitrenium Ion formation >> Aromatic azo OR SN1 >> Nitrenium
Ion formation >> Aromatic N-hydroxylamines OR SN1 >> Nitrenium Ion
formation >> Aromatic nitro OR SN1 >> Nitrenium Ion formation >>
Aromatic nitroso OR SN1 >> Nitrenium Ion formation >> Aromatic
phenylureas OR SN1 >> Nitrenium Ion formation >> Primary (unsaturated)
heterocyclic amine OR SN1 >> Nitrenium Ion formation >> Primary aromatic
amine OR SN1 >> Nitrenium Ion formation >> Secondary (unsaturated)
heterocyclic amine OR SN1 >> Nitrenium Ion formation >> Secondary
aromatic amine OR SN1 >> Nitrenium Ion formation >> Tertiary
(unsaturated) heterocyclic amine OR SN1 >> Nitrenium Ion formation >>
Tertiary aromatic amine OR SN1 >> Nitrenium Ion formation >> Unsaturated
heterocyclic azo OR SN1 >> Nitrenium Ion formation >> Unsaturated
heterocyclic nitro OR SN1 >> Nitrenium Ion formation >> Unsaturated
heterocyclic nitroso OR SN1 >> Nitrenium Ion formation >> Unsaturated
heterocyclic phenylureas OR SN2 OR SN2 >> Direct Acting Epoxides and
related OR SN2 >> Direct Acting Epoxides and related >> Aziridines OR
SN2 >> Direct Acting Epoxides and related >> Epoxides OR SN2 >> Direct
Acting Epoxides and related >> Sulfuranes OR SN2 >> Episulfonium Ion
Formation OR SN2 >> Episulfonium Ion Formation >> 1,2-Dihaloalkanes OR
SN2 >> Episulfonium Ion Formation >> Mustards OR SN2 >> Epoxidation of
Aliphatic Alkenes OR SN2 >> Epoxidation of Aliphatic Alkenes >>
Halogenated polarised alkenes OR SN2 >> Epoxidation of Aliphatic Alkenes
>> Phenoxy polarised alkenes OR SN2 >> Nitrosation-SN2 OR SN2 >>
Nitrosation-SN2 >> Nitroso-SN2 OR SN2 >> P450 Mediated Epoxidation OR
SN2 >> P450 Mediated Epoxidation >> Coumarins OR SN2 >> P450 Mediated
Epoxidation >> Thiophenes-SN2 OR SN2 >> P450 Mediated Sulfoxidation OR
SN2 >> P450 Mediated Sulfoxidation >> Thioureas-SN2 OR SN2 >> SN2 at a
Nitrogen atom OR SN2 >> SN2 at a Nitrogen atom >>
N-acyloxy-N-alkoxyamides OR SN2 >> SN2 at an sp3 Carbon atom OR SN2 >>
SN2 at an sp3 Carbon atom >> Aliphatic halides OR SN2 >> SN2 at an sp3
Carbon atom >> Alkyl carbamates OR SN2 >> SN2 at an sp3 Carbon atom >>
Phosphates OR SN2 >> SN2 at an sp3 Carbon atom >> Phosphonic esters OR
SN2 >> SN2 at an sp3 Carbon atom >> Sulfonates by DNA binding by OECD
Domain
logical expression index: "o"
Referential
boundary: The
target chemical should be classified as Neutral Organics by US-EPA New
Chemical Categories
Domain
logical expression index: "p"
Referential
boundary: The
target chemical should be classified as Aryl AND Aryl halide AND Ether
by Organic Functional groups
Domain
logical expression index: "q"
Referential
boundary: The
target chemical should be classified as Aryl halide AND Ether AND
Overlapping groups by Organic Functional groups (nested)
Domain
logical expression index: "r"
Referential
boundary: The
target chemical should be classified as Aliphatic Carbon [CH] AND
Aliphatic Carbon [-CH2-] AND Aliphatic Carbon [-CH3] AND Aromatic Carbon
[C] AND Bromine, aromatic attach [-Br] AND Bromine, olefinic attach
[-Br] AND Olefinic carbon [=CH- or =C<] AND Oxygen, one aromatic attach
[-O-] by Organic functional groups (US EPA)
Domain
logical expression index: "s"
Referential
boundary: The
target chemical should be classified as Alkylarylether AND Aromatic
compound AND Aryl bromide AND Aryl halide AND Ether AND Halogen
derivative by Organic functional groups, Norbert Haider (checkmol)
Domain
logical expression index: "t"
Referential
boundary: The
target chemical should be classified as Non binder, without OH or NH2
group by Estrogen Receptor Binding
Domain
logical expression index: "u"
Referential
boundary: The
target chemical should be classified as Moderate binder, NH2 group OR
Moderate binder, OH grooup OR Non binder, impaired OH or NH2 group OR
Non binder, MW>500 OR Non binder, non cyclic structure OR Strong binder,
NH2 group OR Strong binder, OH group OR Very strong binder, OH group OR
Weak binder, NH2 group OR Weak binder, OH group by Estrogen Receptor
Binding
Domain
logical expression index: "v"
Referential
boundary: The
target chemical should be classified as Neutral Organics by US-EPA New
Chemical Categories
Domain
logical expression index: "w"
Referential
boundary: The
target chemical should be classified as Aryl AND Aryl halide AND Ether
by Organic Functional groups
Domain
logical expression index: "x"
Referential
boundary: The
target chemical should be classified as Aryl halide AND Ether AND
Overlapping groups by Organic Functional groups (nested)
Domain
logical expression index: "y"
Referential
boundary: The
target chemical should be classified as Aliphatic Carbon [CH] AND
Aliphatic Carbon [-CH2-] AND Aliphatic Carbon [-CH3] AND Aromatic Carbon
[C] AND Bromine, aromatic attach [-Br] AND Bromine, olefinic attach
[-Br] AND Olefinic carbon [=CH- or =C<] AND Oxygen, one aromatic attach
[-O-] by Organic functional groups (US EPA)
Domain
logical expression index: "z"
Referential
boundary: The
target chemical should be classified as Alkylarylether AND Aromatic
compound AND Aryl bromide AND Aryl halide AND Ether AND Halogen
derivative by Organic functional groups, Norbert Haider (checkmol)
Domain
logical expression index: "aa"
Referential
boundary: The
target chemical should be classified as No alert found by Protein
binding by OECD
Domain
logical expression index: "ab"
Referential
boundary: The
target chemical should be classified as Acylation OR Acylation >> Direct
Acylation Involving a Leaving group OR Acylation >> Direct Acylation
Involving a Leaving group >> Acetates OR Acylation >> Direct Acylation
Involving a Leaving group >> Acyl halides (including benzyl and
carbamoyl deriv.) OR Acylation >> Direct Acylation Involving a Leaving
group >> Azlactone OR Acylation >> Direct Acylation Involving a Leaving
group >> Sulphonyl halides OR Acylation >> Isocyanates and Related
Chemicals OR Acylation >> Isocyanates and Related Chemicals >>
Isocyanates OR Acylation >> Isocyanates and Related Chemicals >>
Isothiocyanates OR Acylation >> Isocyanates and Related Chemicals >>
Thiocyanates-Acylation OR Acylation >> Ring Opening Acylation OR
Acylation >> Ring Opening Acylation >> alpha-Lactams OR Michael addition
OR Michael addition >> Polarised Alkenes OR Michael addition >>
Polarised Alkenes >> Polarised alkene - amides OR Michael addition >>
Polarised Alkenes >> Polarised alkene - cyano OR Michael addition >>
Polarised Alkenes >> Polarised alkene - esters OR Michael addition >>
Polarised Alkenes >> Polarised alkene - ketones OR Michael addition >>
Polarised Alkenes >> Polarised alkene - nitro OR Michael addition >>
Polarised Alkenes >> Polarised alkene - pyridines OR Michael addition >>
Quinones and Quinone-type Chemicals OR Michael addition >> Quinones and
Quinone-type Chemicals >> Benzoquinones OR Michael addition >> Quinones
and Quinone-type Chemicals >> Pyranones (and related nitrogen chemicals)
OR Michael addition >> Quinones and Quinone-type Chemicals >>
Quinone-diimine OR Schiff Base Formers OR Schiff Base Formers >> Direct
Acting Schiff Base Formers OR Schiff Base Formers >> Direct Acting
Schiff Base Formers >> 1-2-Dicarbonyls OR Schiff Base Formers >> Direct
Acting Schiff Base Formers >> 1-3-Dicarbonyls OR Schiff Base Formers >>
Direct Acting Schiff Base Formers >> Mono-carbonyls OR SN2 OR SN2 >>
Episulfonium Ion Formation OR SN2 >> Episulfonium Ion Formation >>
1,2-Dihaloalkane OR SN2 >> Episulfonium Ion Formation >> Mustards OR SN2
>> Epoxides and Related Chemicals OR SN2 >> Epoxides and Related
Chemicals >> Epoxides OR SN2 >> Epoxides and Related Chemicals >>
Sulfuranes OR SN2 >> SN2 reaction at a nitrogen atom OR SN2 >> SN2
reaction at a nitrogen atom >> N-Acetoxy-N-acetyl-phenyl OR SN2 >> SN2
reaction at a nitrogen atom >> N-Acyloxy-N-alkoxyamides OR SN2 >> SN2
reaction at a sp2 carbon atom OR SN2 >> SN2 reaction at a sp2 carbon
atom >> Polarised alkenes with a halogen leaving group OR SN2 >> SN2
reaction at a sulphur atom OR SN2 >> SN2 reaction at a sulphur atom >>
Aromatic sulphonic acids OR SN2 >> SN2 reaction at a sulphur atom >>
Disulfides OR SN2 >> SN2 reaction at a sulphur atom >> Sulfoxides of
disulfides OR SN2 >> SN2 reaction at a sulphur atom >> Thiocyanates-SN2
OR SN2 >> SN2 reaction at a sulphur atom >> Thiols OR SN2 >> SN2
reaction at sp3 carbon atom OR SN2 >> SN2 reaction at sp3 carbon atom >>
Alkyl diazo OR SN2 >> SN2 reaction at sp3 carbon atom >> Alkyl halides
OR SN2 >> SN2 reaction at sp3 carbon atom >> Allyl acetates and related
chemicals OR SN2 >> SN2 reaction at sp3 carbon atom >> alpha-Halo ethers
OR SN2 >> SN2 reaction at sp3 carbon atom >> alpha-Haloalkenes (and
related cyano, sulfate and sulfonate subs. chem.) OR SN2 >> SN2 reaction
at sp3 carbon atom >> alpha-Haloalkynes (and related cyano, sulfate,
sulphpnate subs. chem.) OR SN2 >> SN2 reaction at sp3 carbon atom >>
alpha-Halobenzyls (and related cyano, sulfate and sulphonate subs.
chem.) OR SN2 >> SN2 reaction at sp3 carbon atom >> alpha-Halocarbonyls
OR SN2 >> SN2 reaction at sp3 carbon atom >> beta-Halo ethers OR SN2 >>
SN2 reaction at sp3 carbon atom >> Phosphates OR SN2 >> SN2 reaction at
sp3 carbon atom >> Phosphonates OR SN2 >> SN2 reaction at sp3 carbon
atom >> Sulfonates OR SN2 >> SN2 reaction at sp3 carbon atom >>
Thiophosphates OR SNAr OR SNAr >> Nucleophilic aromatic substitution OR
SNAr >> Nucleophilic aromatic substitution >> Activated halo-benzenes OR
SNAr >> Nucleophilic aromatic substitution >> Activated halo-pyridines
OR SNAr >> Nucleophilic aromatic substitution >> Halo-pyrimidines OR
SNAr >> Nucleophilic aromatic substitution >> Halo-triazines by Protein
binding by OECD
Domain
logical expression index: "ac"
Referential
boundary: The
target chemical should be classified as Neutral Organics by US-EPA New
Chemical Categories
Domain
logical expression index: "ad"
Referential
boundary: The
target chemical should be classified as Aryl AND Aryl halide AND Ether
by Organic Functional groups
Domain
logical expression index: "ae"
Referential
boundary: The
target chemical should be classified as Aryl halide AND Ether AND
Overlapping groups by Organic Functional groups (nested)
Domain
logical expression index: "af"
Referential
boundary: The
target chemical should be classified as Aliphatic Carbon [CH] AND
Aliphatic Carbon [-CH2-] AND Aliphatic Carbon [-CH3] AND Aromatic Carbon
[C] AND Bromine, aromatic attach [-Br] AND Bromine, olefinic attach
[-Br] AND Olefinic carbon [=CH- or =C<] AND Oxygen, one aromatic attach
[-O-] by Organic functional groups (US EPA)
Domain
logical expression index: "ag"
Referential
boundary: The
target chemical should be classified as Alkylarylether AND Aromatic
compound AND Aryl bromide AND Aryl halide AND Ether AND Halogen
derivative by Organic functional groups, Norbert Haider (checkmol)
Domain
logical expression index: "ah"
Referential
boundary: The
target chemical should be classified as No alert found by Protein
binding by OECD
Domain
logical expression index: "ai"
Referential
boundary: The
target chemical should be classified as Acylation OR Acylation >> Direct
Acylation Involving a Leaving group OR Acylation >> Direct Acylation
Involving a Leaving group >> Acetates OR Acylation >> Direct Acylation
Involving a Leaving group >> Acyl halides (including benzyl and
carbamoyl deriv.) OR Acylation >> Direct Acylation Involving a Leaving
group >> Azlactone OR Acylation >> Direct Acylation Involving a Leaving
group >> Sulphonyl halides OR Acylation >> Isocyanates and Related
Chemicals OR Acylation >> Isocyanates and Related Chemicals >>
Isocyanates OR Acylation >> Isocyanates and Related Chemicals >>
Isothiocyanates OR Acylation >> Isocyanates and Related Chemicals >>
Thiocyanates-Acylation OR Acylation >> Ring Opening Acylation OR
Acylation >> Ring Opening Acylation >> alpha-Lactams OR Michael addition
OR Michael addition >> Polarised Alkenes OR Michael addition >>
Polarised Alkenes >> Polarised alkene - amides OR Michael addition >>
Polarised Alkenes >> Polarised alkene - cyano OR Michael addition >>
Polarised Alkenes >> Polarised alkene - esters OR Michael addition >>
Polarised Alkenes >> Polarised alkene - ketones OR Michael addition >>
Polarised Alkenes >> Polarised alkene - nitro OR Michael addition >>
Polarised Alkenes >> Polarised alkene - pyridines OR Michael addition >>
Quinones and Quinone-type Chemicals OR Michael addition >> Quinones and
Quinone-type Chemicals >> Benzoquinones OR Michael addition >> Quinones
and Quinone-type Chemicals >> Pyranones (and related nitrogen chemicals)
OR Michael addition >> Quinones and Quinone-type Chemicals >>
Quinone-diimine OR Schiff Base Formers OR Schiff Base Formers >> Direct
Acting Schiff Base Formers OR Schiff Base Formers >> Direct Acting
Schiff Base Formers >> 1-2-Dicarbonyls OR Schiff Base Formers >> Direct
Acting Schiff Base Formers >> 1-3-Dicarbonyls OR Schiff Base Formers >>
Direct Acting Schiff Base Formers >> Mono-carbonyls OR SN2 OR SN2 >>
Episulfonium Ion Formation OR SN2 >> Episulfonium Ion Formation >>
1,2-Dihaloalkane OR SN2 >> Episulfonium Ion Formation >> Mustards OR SN2
>> Epoxides and Related Chemicals OR SN2 >> Epoxides and Related
Chemicals >> Epoxides OR SN2 >> Epoxides and Related Chemicals >>
Sulfuranes OR SN2 >> SN2 reaction at a nitrogen atom OR SN2 >> SN2
reaction at a nitrogen atom >> N-Acetoxy-N-acetyl-phenyl OR SN2 >> SN2
reaction at a nitrogen atom >> N-Acyloxy-N-alkoxyamides OR SN2 >> SN2
reaction at a sp2 carbon atom OR SN2 >> SN2 reaction at a sp2 carbon
atom >> Polarised alkenes with a halogen leaving group OR SN2 >> SN2
reaction at a sulphur atom OR SN2 >> SN2 reaction at a sulphur atom >>
Aromatic sulphonic acids OR SN2 >> SN2 reaction at a sulphur atom >>
Disulfides OR SN2 >> SN2 reaction at a sulphur atom >> Sulfoxides of
disulfides OR SN2 >> SN2 reaction at a sulphur atom >> Thiocyanates-SN2
OR SN2 >> SN2 reaction at a sulphur atom >> Thiols OR SN2 >> SN2
reaction at sp3 carbon atom OR SN2 >> SN2 reaction at sp3 carbon atom >>
Alkyl diazo OR SN2 >> SN2 reaction at sp3 carbon atom >> Alkyl halides
OR SN2 >> SN2 reaction at sp3 carbon atom >> Allyl acetates and related
chemicals OR SN2 >> SN2 reaction at sp3 carbon atom >> alpha-Halo ethers
OR SN2 >> SN2 reaction at sp3 carbon atom >> alpha-Haloalkenes (and
related cyano, sulfate and sulfonate subs. chem.) OR SN2 >> SN2 reaction
at sp3 carbon atom >> alpha-Haloalkynes (and related cyano, sulfate,
sulphpnate subs. chem.) OR SN2 >> SN2 reaction at sp3 carbon atom >>
alpha-Halobenzyls (and related cyano, sulfate and sulphonate subs.
chem.) OR SN2 >> SN2 reaction at sp3 carbon atom >> alpha-Halocarbonyls
OR SN2 >> SN2 reaction at sp3 carbon atom >> beta-Halo ethers OR SN2 >>
SN2 reaction at sp3 carbon atom >> Phosphates OR SN2 >> SN2 reaction at
sp3 carbon atom >> Phosphonates OR SN2 >> SN2 reaction at sp3 carbon
atom >> Sulfonates OR SN2 >> SN2 reaction at sp3 carbon atom >>
Thiophosphates OR SNAr OR SNAr >> Nucleophilic aromatic substitution OR
SNAr >> Nucleophilic aromatic substitution >> Activated halo-benzenes OR
SNAr >> Nucleophilic aromatic substitution >> Activated halo-pyridines
OR SNAr >> Nucleophilic aromatic substitution >> Halo-pyrimidines OR
SNAr >> Nucleophilic aromatic substitution >> Halo-triazines by Protein
binding by OECD
Domain
logical expression index: "aj"
Referential
boundary: The
target chemical should be classified as No superfragment by
Superfragments ONLY
Domain
logical expression index: "ak"
Referential
boundary: The
target chemical should be classified as Class 1 (narcosis or baseline
toxicity) by Acute aquatic toxicity classification by Verhaar (Modified)
ONLY
Domain
logical expression index: "al"
Referential
boundary: The
target chemical should be classified as Moderate by Bioaccumulation -
metabolism half-lives ONLY
Domain
logical expression index: "am"
Parametric
boundary:The
target chemical should have a value of Molecular weight which is >= 147
Da
Domain
logical expression index: "an"
Parametric
boundary:The
target chemical should have a value of Molecular weight which is <= 201
Da
Description of key information
Biodegradability of 1 -Bromo-3 -methoxybenzene (CAS no. 2398 -37 -0) is predicted using QSAR toolbox version 3.3 (2017). Test substance undergoes 0.125% degradation by BOD in 28 days. Thus, based on percentage degradation, the test chemical 1 -Bromo-3 -methoxybenzene was estimated to be not readily biodegradable in water.
Key value for chemical safety assessment
- Biodegradation in water:
- under test conditions no biodegradation observed
Additional information
2 predicted data for the target compound 1-Bromo-3-methoxybenzene (CAS No. 2398-37-0) and the total 3 studies (from authoritative database) for its closest read across substances with logKow as the primary descriptor were reviewed for the biodegradation end point which are summarized as below:
In a prediction done by SSS (2017) using QSAR toolbox version 3.3 with logKow as the primary descriptor, percentage biodegradability of test chemical 1-Bromo-3 -methoxybenzene (CAS no. 2398 -37 -0) was estimated. Test substance undergoes 0.125% degradation by BOD in 28 days. Thus, based on percentage degradation, the test chemical 1 -Bromo-3 -methoxybenzene was estimated to be not readily biodegradable in water.
In another prediction using the Estimation Programs Interface Suite (EPI suite, 2017), the biodegradation potential of the test compound 1 -Bromo-3 -methoxybenzene (CAS no. 2398 -37 -0) in the presence of mixed populations of environmental microorganisms was estimated. The biodegradability of the substance was calculated using seven different models such as Linear Model, Non-Linear Model, Ultimate Biodegradation Timeframe, Primary Biodegradation Timeframe, MITI LInear Model, MITI Non-Linear Model and Anaerobic Model (called as Biowin 1-7, respectively) of the BIOWIN v4.10 software. The results indicate that 1 -Bromo-3 -methoxybenzene is expected to be not readily biodegradable.
In a weight of evidence study from authoritative database (J-CHECK, 2016) and secondary source (OECD SIDS, 1995) for read across substance 2,4 -Dichloro-1 -methylbenzene (CAS no. 95 -73 -8) , biodegradation experiment was conducted for 28 days for evaluating the percentage biodegradability of read across substance 2,4-Dichloro-1-methylbenzene. The study was performed according to OECD Guideline 301 C (Ready Biodegradability: Modified MITI Test (I)). Concentration of inoculum i.e, sludge used was 30 mg/l and initial test substance conc. used in the study was 100 mg/l, respectively. The percentage degradation of read across substance was determined to be 0% by BOD and GC parameter in 28 days. Thus, based on percentage degradation, 2,4-Dichloro-1-methylbenzene is considered to be not readily biodegradable in nature.
Another supporting weight of evidence study was conducted for 28 days for evaluating the percentage biodegradability of read across substance (4 -Chloro-2 -methylphenoxy)acetic acid (CAS no. 94 -74 -6) (J-CHECK, 2016). Concentration of inoculum i.e, sludge used was 30 mg/l and initial test substance conc. used in the study was 100 mg/l, respectively. The percentage degradation of read across substance was determined to be 1, 0 and 2% by BOD, O2 consumption, TOC removal, test mat. analysis and HPLC parameter in 28 days. Thus, based on percentage degradation, (4 -Chloro-2 -methylphenoxy)acetic acid is considered to be not readily biodegradable in nature.
In an additional study of read across substance substance1-Chloronaphthalene (CAS no. 90 -13 -1) from authoritative database (J-CHECK, 2016), biodegradation experiment was carried out for 14 days for evaluating the percentage biodegradability of the substance. Concentration of inoculum i.e, sludge used was 30 mg/l and initial test substance conc. used in the study was 100 mg/l, respectively. The percentage degradation of read across substance was determined to be 0 and 1% by BOD and GC parameter in 14 days. Thus, based on percentage degradation, 1 -Chloronaphthalene is considered to be not readily biodegradable in nature.
On the basis of above results for target chemical1 -Bromo-3 -methoxybenzene(from OECD QSAR toolbox version 3.3 and EPI Suite) and for its read across substance (from authoritative database J-CHECK), it can be concluded that the test substance1 -Bromo-3 -methoxybenzene can be expected to be not readily biodegradable in nature.
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