Registration Dossier
Registration Dossier
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EC number: 203-856-5 | CAS number: 111-30-8
Specific investigations: other studies
Administrative data
- Endpoint:
- specific investigations: other studies
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Scientifically acceptable data.
Data source
Reference
- Reference Type:
- publication
- Title:
- Subcellular localization of 14C-glutaraldehyde in liver cells.
- Author:
- Amstutz L, Ranly D
- Year:
- 1 989
- Bibliographic source:
- J. Dent. Res. 68: 203, Abstract 176
Materials and methods
- Principles of method if other than guideline:
- The aim of the study was to determine if glutaraldehyde can associate with the nucleus of living cells, thereby posing a mutagenic threat. For this purpose, C14-radiolabelled glutardialdehyde was infused i.v.in rats; the animals were sacrificed after 5 minutes and 1 hour and liver samples were collected and examined for radioactivity distribution.
- GLP compliance:
- no
- Type of method:
- in vitro
- Endpoint addressed:
- other: subcellular localisation in liver cells
Test material
- Reference substance name:
- Glutaral
- EC Number:
- 203-856-5
- EC Name:
- Glutaral
- Cas Number:
- 111-30-8
- Molecular formula:
- C5H8O2
- IUPAC Name:
- glutaraldehyde
- Test material form:
- liquid
Constituent 1
- Specific details on test material used for the study:
- Glutaraldehyde, no further data given.
Test animals
- Species:
- rat
Administration / exposure
- Route of administration:
- intravenous
- Details on study design:
- C14-radiolabelled glutardialdehyde was infused i.v.in rats; the animals were sacrificed after 5 minutes and 1 hour. Liver samples were collected and homogenized, and the extracellular material was removed by centrifugation. The remained components (cytosol, membrane, nucleus) were separated in fractions, and the volume, protein content and radioactivity of each fraction was determined for each of them.
Results and discussion
- Details on results:
- The findings showed that between 5 minutes and 1 hour, the cytosolic radioactivity content increased from 40 to 60% of the total tissue count whereas the membrane-bound radioactivity increased from 14 to 26%. The radioactivity related to the nuclear fraction was 0.5% of the total tissue count and remained stable between 5 minutes and 1 hour.
Any other information on results incl. tables
The finding of present study showed that glutaraldehyde administered i.v. to rats was incorporated in liver cells but did not reach the nucleus to a significant extent.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
