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EC number: 208-358-1 | CAS number: 524-38-9
Endpoint summary
Administrative data
Description of key information
Adsorption / desorption
The Soil Adsorption Coefficient i.e Koc value of 2-hydroxy-1H-isoindole-1,3(2H)-dione was estimated using EPI suite KOCWIN (v2.00) as Koc 10 L/kg (log Koc = 1) by means of MCI method at 25 deg.C. This Koc value indicates that the substance 2-hydroxy-1H-isoindole-1,3(2H)-dione has a negligible sorption to soil and sediment and therefore have rapid migration potential to groundwater.
Additional information
Adsorption / desorption
Four different predicted data from validated model and experimental data from authorative database for adsorption (KOC) endpoint of test substance 2-hydroxy-1H-isoindole-1,3(2H)-dione (Cas no. 524-38-9) with relevant read across which is structurally similar to target were summarized as follows:
First estimation using KOCWIN model (v2.00) of EPI suite indicated the Soil Adsorption Coefficient i.e Koc value of 2-hydroxy-1H-isoindole-1,3(2H)-dione as Koc 10 L/kg (log Koc = 1) by means of MCI method at 25 deg.C. This Koc value indicates that the substance 2-hydroxy-1H-isoindole-1,3(2H)-dione has a negligible sorption to soil and sediment and therefore have rapid migration potential to groundwater.
Another prediction model for target i.e Chemspider - ACD/PhysChem Suite suggest the soil adsorption coefficient i.e Koc value of test substance 2-hydroxy-1H-isoindole-1,3(2H)-dione was estimated to be 44.58 (log koc: 1.64 ) at pH 5.5 and temp.25 deg.C this Koc value at 5.5 pH indicates that the substance 2-hydroxy-1H-isoindole-1,3(2H)-dione has negligible sorption to soil and sediment and therefore have rapid to moderate migration potential to groundwater.
Above both results are supported by another prediction database Scifinder, which indicated the soil adsorption coefficient i.e Koc value of test substance 2-hydroxy-1H-isoindole-1,3(2H)-dione was estimated to be 130-131 (Log koc: 2.11) at pH 1-4; 121 (Log koc: 2.08) at pH 5; 73.0 (Log koc:1.86) at pH 6 and 14.7 (Log koc:1.16) at temperature 25 deg.C. This Koc value at all range of pH condition indicates that the substance 2-hydroxy-1H-isoindole-1,3(2H)-dionehas negligible to low sorption to soil and sediment and therefore have rapid to moderate migration potential to groundwater.
Experimental data of read across chemical Phthalimide (Cas no. 85-41-6) give assistance to all three predicted results of target. The result suggest the Koc of phthalimide is estimated as approximately 100, using an experimental log Kow of 1.15 and a regression derived equation.This estimated Koc value suggests that phthalimide should have moderate to high mobility in soil.
Thus all above available values for adsorption (log KOC) is in the range of 1 to 2.11 (L/kg or dimensionless) which concluded that the target substance 2-hydroxy-1H-isoindole-1,3(2H)-dione (Cas no. 524-38-9) is expected to have high mobility in soil and sediment compartment.
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