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Diss Factsheets

Toxicological information

Acute Toxicity: oral

Currently viewing:

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data is from peer-reviewed journal

Data source

Reference
Reference Type:
publication
Title:
Monographs on fragrance raw materials: p-Cresyl acetate
Author:
Denine
Year:
1974
Bibliographic source:
Food and Cosmetics Toxicology, Volume 12, Issue 3, June 1974, Pages 391

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
The study was conducted to evaluate the acute toxic effects of administration of p-tolyl acetate (CAS No. 140-39-6) in rats by the oral route.
GLP compliance:
not specified
Test type:
other: No data
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
p-tolyl acetate
EC Number:
205-413-1
EC Name:
p-tolyl acetate
Cas Number:
140-39-6
Molecular formula:
C9H10O2
IUPAC Name:
4-methylphenyl acetate
Test material form:
liquid
Specific details on test material used for the study:
- Name of the test material (IUPAC): 4-methylphenyl acetate
- Molecular Formula: C9H10O2
- Molecular Weight: 150.176 g/mol
- Substance type: Organic
- Physical state: Liquid
- Purity: No data
- Smiles: c1(ccc(C)cc1)OC(C)=O

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
No data available

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
not specified
Details on oral exposure:
No data available
Doses:
No data available
No. of animals per sex per dose:
No data available
Control animals:
not specified
Details on study design:
No data available
Statistics:
No data available

Results and discussion

Preliminary study:
No data available
Effect levels
Key result
Sex:
not specified
Dose descriptor:
LD50
Effect level:
1 900 mg/kg bw
Based on:
test mat.
95% CL:
1 120 - 3 230
Remarks on result:
other: 50 % mortality observed
Mortality:
50 % mortality was observed in treated rats at 1900 mg/kg bw.
Clinical signs:
other: No data available
Gross pathology:
No data available
Other findings:
No data available

Applicant's summary and conclusion

Interpretation of results:
other: Category 4 based on CLP criteria
Conclusions:
LD50 was considered to be 1900 mg/kg bw (1120 -3230) when rats were treated with 4-methylphenyl acetate orally
The acute oral median lethal dose (LD50) of p-tolyl acetate in rat was observed to be 1900 mg/kg bw with 95%CL of 1120 -3230 mg/kg bw.
Executive summary:

The study was conducted to evaluate the acute toxic effects of administration of p-tolyl acetate (CAS No. 140-39-6) in rats by the oral route. 50 % mortality was observed in treated rats at 1900 mg/kg bw. Therefore, the acute oral median lethal dose (LD50) of p-tolyl acetate in rat was observed to be 1900 mg/kg bw with 95%CL of 1120 -3230 mg/kg bw. Thus, according to CLP criteria for acute toxicity rating for the chemicals, it infers that p-tolyl acetate (CAS No. 140-39-6) can be classify as an acute oral toxicant in category 4.