Registration Dossier
Registration Dossier
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EC number: 205-413-1 | CAS number: 140-39-6
Endpoint summary
Administrative data
Description of key information
Bioaccumulation: aquatic / sediment
Based on the predicted data by BCFBAF Program (v3.01) model the Bioaccumulation factor (BCF) was predicted to be 11.46 L/kg wet-wt at 25 deg.C. Based on the BCF concentration it is concluded that the test chemical p-tolyl acetate is non bioaccumulative in nature as it does not exceed the BCF criteria of 2000.
Additional information
Bioaccumulation: aquatic / sediment
By applying weight of evidence approach to Bioaccumulation potential for the target chemical p-tolyl acetate (Cas no. 140-39-6) and its read across chemical which is 60-70 % structurally similar to target were reviewed to summarize as follows:
First study from prediction model EPI suite 2017 using BCFBAF Program (v3.01) model the Bioaccumulation factor (BCF) was predicted to be 11.46 L/kg wet-wt at 25 deg.C.
Similarly another prediction model PBT profiler; 2017 indicated that the Bioaccumulation factor (BCF) was predicted to be 11 L/kg wet-wt at 25 deg.C for target p-tolyl acetate.
One another predicted database i.e Scifinder; 2017 for target substance indicate the Bioconcentration factor (BCF) was predicted to be 22.4 at pH 1-10 and temperature 25 deg.C.
Information from Chemspider - ACD/PhysChem Suite prediction model, for the Bioconcentration factor (BCF) for target chemical p-tolyl acetate was predicted to be 25.47 at pH 5.5 and 7.4 and temperature 25 deg.C.
Whereas data from HSDB database; 2017 for read across chemical Phenyl acetate (Cas no. 122-79-2) indicate an estimated BCF of 8 was calculated for phenyl acetate, using a log Kow value of 1.49 and a regression-derived equation. This BCF suggests the potential for bioconcentration in aquatic organisms is low.
Thus based on the above all studies it is concluded that the test substance chemical p-tolyl acetate (Cas no. 140-39-6) is non Bioaccumulative in aquatic environment.
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