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EC number: 680-341-5 | CAS number: 41438-38-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From July 06, 2010 to July 27, 2011
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- Study conducted in compliance with agreed protocols, with no or minor deviations from standard test guidelines and/or minor methodological deficiencies, which do not affect the quality of the relevant results. The study report was conclusive, done to a valid guideline and the study was conducted under GLP conditions.
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient)
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- shake-flask method to: flask method
- Remarks:
- EXA
- Partition coefficient type:
- octanol-water
- Analytical method:
- high-performance liquid chromatography
- Type:
- log Pow
- Partition coefficient:
- 1.92
- Temp.:
- 20 °C
- pH:
- 7.82
- Conclusions:
- During this study the partition coefficient (n-octanol / water) of MEXORYL SBU was determined and found to belog POW = 1.92 at 20 °Cusing the HPLC method. The pH of the test item solution was 7.82
- Executive summary:
During this study the partition coefficient (n-octanol / water) of MEXORYL SBU was determined using the HPLC- method as described inDirective 92/69, A.8 “Partition Coefficient” (2008), the Council Regulation (EC) 440/2008, A.8 and in the OECD Guideline No. 117, “Partition Coefficient (n-Octanol / Water), High Performance Liquid Chromatography (HPLC) method” (2004).
Six common standards, which have known log POWvalues were used as reference standards. For the determination of the dead time a thiourea solution was used. From the regression curve (log k' vs. log POW) the n-octanol / water partition coefficient (log POW) of MEXORYL SBU was calculated and found to be
log POW = 1.92 at 20 °C.
The pH of the test item solution was 7.82.
Reference
Results and Discussion
During the preliminary test, the log POWof MEXORYL SBU was estimated to be >1.60. Thus having the free choice between both methods, the HPLC-method was chosen to conduct the main test. Six common standards, which have known log POWvalues in the range of 0.9 to 4.2, were used as reference standards during the main test.
The MEXORYL SBU solution was injected three times and the combined reference solution was injected six times. The thiourea solution was injected three times. The log POWof the test item was calculated using a regression curve (log k' vs. log POW) and was found to be 1.92.The resultant log POWwas in the range of the estimated value found during the preliminary test.
The chromatography of the test item showed one sharp main peak with a well-defined and reproducible retention time. The HPLC method was therefore considered to be suitable for the purpose of the study. Based on the chromatographic data, MEXORYL SBU was considered to be stable during the test procedure.
Using the corresponding log POWvalues of the reference items from the OECD guideline, the regression coefficients were calculated. The log POWvalue of the test item was calculated from the calibration equation.
Description of key information
During this study the partition coefficient (n-octanol / water) of MEXORYL SBU was determined using the HPLC- method as described inDirective 92/69, A.8 “Partition Coefficient” (2008), the Council Regulation (EC) 440/2008, A.8 and in the OECD Guideline No. 117, “Partition Coefficient (n-Octanol / Water), High Performance Liquid Chromatography (HPLC) method” (2004).
Six common standards, which have known log POWvalues were used as reference standards. For the determination of the dead time a thiourea solution was used. From the regression curve (log k' vs. log POW) the n-octanol / water partition coefficient (log POW) of MEXORYL SBU was calculated and found to be
log POW = 1.92 at 20 °C.
The pH of the test item solution was 7.82.
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 1.92
- at the temperature of:
- 20 °C
Additional information
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