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EC number: 245-890-3 | CAS number: 23787-90-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
Description of key information
Study Title:PICONIA : A Flow-Through Bioconcentration Screening Test with Rainbow Trout (Oncorhynchus mykiss). OECD 305. Project number:558A-116 (RIFM , 2011).
Additional data on Piconia (previous trade name for Isolongifolanone) - a Fish Bioaccumulation study supports the result of 'Not Readily Biodegradable' from biodegradability study.
Rainbow trout (O. mykiss) were exposed to a single test concentration of PICONIA (CAS No. 23787-90-8) of 44.5 µg a.i./L. A Kinetic Bioconcentration Factor (BCFk) of 381 L/kg wet wt was determined.
Key value for chemical safety assessment
Additional information
Key Value for Chemical Safety Assessment - BCFk 381 L/kg wet wt.
Rainbow trout (O. mykiss) were exposed to a single test concentration of PICONIA (CAS No. 23787-90-8). The nominal concentration of 50 µg a.i./L was selected in consultation with the Sponsor and is approximately 1% of the estimated LC50 concentration. Fish were exposed in a single tank. No Control groups were used in this test. The test was divided in to two phases. Uptake and Depuration. During the Uptake phase, the fish were exposed under flow-through conditions to a sub-lethal concentration of the test substance at 12 ± 1°C. The duration of the Uptake phase was 28 Days and the Depuration phase was 15 Days. During both phases of the test, test organisms and water samples were collected and analysed for test substance content to determine the Uptake Rate Constant (k1), the Depuration Rate Constant (k2), and, subsequently< the kinetic bioconcentration factor (BCFk) for whole-body tissues. On each sampling day, six fish were collected and composited to make one sample, with four composite samples being collected at each sampling day for each treatment group.
Physical and Chemical Measurements of Water – Water temperature ranged between 12.0 and 12.6°C. Dissolved oxygen concentrations remained ≥ 8.0 mg/L (74% saturation) throughout the test. Water pH ranged from 8.0 to 8.3. Total Organic Carbon in the test chambers was < 1 mg C/L throughout the test.
Observations of Mortality and Clinical Signs of Toxicity – All fish in the treatment group appeared normal throughout the test with no treatment-related mortalities or signs of toxicity.
Concentrations of PICONIA in Water – The nominal test concentration was 50 µg a.i./L. The measured concentrations of PICONIA in the exposure water ranged from 83.9 to 92.4% of nominal, with a mean of 89% (44.5 µg a.i./L) throughout the study.
Concentrations of PICONIA in Fish Tissues – The mean measured tissue concentration of PICONIA in whole fish at Day 28 of the Uptake phase was 16.95 µg a.i./g.
CONCLUSIONS
The Kinetic BCF (BCFk) value for PICONIA in Rainbow Trout (O. mykiss) was calculated for the 44.5 µg a.i./L treatment group (mean measured concentration) using a reduced sampling guideline study. The BCFk value for PICONIA in whole fish tissue was determined to be 381 L/kg wet wt. The estimated time to reach 90% of steady state during the Uptake phase was 9.14 days. The Day 14 Depuration tissue concentration was approximately 3% of the Day 28 Uptake mean tissue concentration. The estimated time to reach 50% clearance for whole fish tissue concentrations was established to be 2.75 Days.
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