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Diss Factsheets
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EC number: 607-520-2 | CAS number: 250640-08-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_environmental-fate-and-pathways.png)
Additional information on environmental fate and behaviour
Administrative data
- Endpoint:
- additional information on environmental fate and behaviour
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2021
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 021
- Report date:
- 2021
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: OECD 318
- GLP compliance:
- no
Test material
- Test material form:
- solid: nanoform, no surface treatment
- Details on test material:
- - Batch: PG10631
- Appearance: solid orange
- Shape of particles: see boundary composition
- Surface area of particles: BET 20.3 m2/g
- Crystal structure: crystalline
- Coating: none
- Expiry date: 2022
Constituent 1
Results and discussion
Any other information on results incl. tables
After 6h, the samples showed high dispersion stability in 0 mM Ca and at any Ca concentration at pH 9. For the samples at all other conditions the stability was intermediate
After 24 hours the stability at pH 9 regardless the Ca concentration remained high. The stability at pH 4 in 1 and 10 mM Ca became low. The stability at all other conditions was intermediate.
Full results of the dispersion stability in the presence of NOM | |||||||
Ca(NO3)2 | Stability after 6h | Standard deviation | Stability after 15h | Standard deviation | Stability after 24h | Standard deviation | |
[mM] | [%] | [%] | [%] | [%] | [%] | [%] | |
pH 4 | 0 | 99.2 | 0.3 | 93.1 | 0.9 | 73.0 | 5.7 |
pH 4 | 1 | 21.3 | 2.0 | 9.7 | 1.2 | 7.9 | 0.9 |
pH 4 | 10 | 19.1 | 1.0 | 9.3 | 0.7 | 7.6 | 0.8 |
. | |||||||
pH 7 | 0 | 101.5 | 0.9 | 98.9 | 1.3 | 88.2 | 1.8 |
pH 7 | 1 | 89.1 | 3.0 | 83.0 | 2.1 | 82.9 | 3.0 |
pH 7 | 10 | 73.3 | 0.7 | 70.9 | 0.6 | 71.8 | 0.3 |
. | |||||||
pH 9 | 0 | 104.1 | 3.7 | 103.8 | 3.5 | 106.4 | 3.2 |
pH 9 | 1 | 100.7 | 0.2 | 100.1 | 0.0 | 102.5 | 0.7 |
pH 9 | 10 | 100.9 | 2.4 | 101.0 | 2.4 | 101.3 | 2.4 |
To rationalize the observed dispersion stability, we finally checked the particle size distribution directly in the environmental medium. We applied the NanoDefine method of Analytical Ultracentrifugation (SOP AUC-RI). The centrifugation parameters are given in the methods section.
As required by TG318, paragraph 31, the tested nanomaterial was pre-wetted in ultrapure water and left in the form of wet-paste for 24 h. The TG318 requires this step “to insure the proper interaction of nanomaterial surface with ultrapure water.” We visually observed incomplete wetting, and so any ensuing measurement would have been incorrect. In accord with the NanoGenoTox dispersion protocol, a drop of ethanol was added, successfully transferred the powder into a paste, which was then further diluted as specified in the TG318
The observed size distributions confirm the moderate agglomeration at 1 mM Ca, pH7, with NOM. If the particles would have been significantly dissolved, no size distribution would be observable at all by this method, which relies on the detection of the movement of particles during centrifugal separation.
Additionally, the centrifugation methods include a determination of the remaining absorption after centrifugation, fully consistent with the conventional determination of the dissolved fraction after centrifugation as recommended by the TG-318. The remaining absorption was measured at ca. 0.77. This is a fraction of 38% of the initial absorption, which indicates that significant fraction of material have been dissolved at that conditions.
Applicant's summary and conclusion
- Conclusions:
- After 6h, the samples showed high dispersion stability in 0 mM Ca and at any Ca concentration at pH 9. For the samples at all other conditions the stability was intermediate
After 24 hours the stability at pH 9 regardless the Ca concentration remained high. The stability at pH 4 in 1 and 10 mM Ca became low. The stability at all other conditions was intermediate.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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