Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 276-649-0 | CAS number: 72403-66-8
Endpoint summary
Administrative data
Key value for chemical safety assessment
Genetic toxicity in vitro
Description of key information
OECD 471, 1994, positive
modified OECD 471, analogue substance, 2020, positive
OECD 476, in vitro HPRT, 1995, negative
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (positive)
Genetic toxicity in vivo
Description of key information
OECD 474, 2002, in vivo MNT, analogue substance, negative
OECD 489, testing proposal, analogue substance, to be performed
Endpoint conclusion
- Endpoint conclusion:
- no study available (further information necessary)
Additional information
Justification for classification or non-classification
A read across approach is proposed for assessing the in vivo gene mutation properties of the taregt substance, by using the results of a Comet Assay OECD 489 submitted as testing proposal on analogue substance.
The Comet Assay requirement is the results of the application of Column 2 Annex VII of the REACH Regulation which requires that substances with positive results for in vitro gene mutation study in bacteria are further investigated for their mutagenic properties in vivo.
Based on the available information no final conclusion on genotoxicity classification can be drawn since further in vivo data are required.
The dossier will be promptly updated when reliable and pertinent results for the substance will be available.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
