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EC number: 203-837-1 | CAS number: 111-13-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
- Toxic effect type:
- dose-dependent
Effects on fertility
Description of key information
Reproductive toxicity study
Based on the data available from different studies, NOAEL for test material was considered to be 1000mg/kg /day for reproductive toxicity, when male and female rats were treated with test material orally. Thus, comparing this value with the criteria of CLP regulation test material is not likely to classify as reproductive toxicant.
Link to relevant study records
- Endpoint:
- screening for reproductive / developmental toxicity
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Justification for type of information:
- Data is from peer reviewed publication
- Qualifier:
- according to guideline
- Guideline:
- other: No data
- Principles of method if other than guideline:
- To evaluate the reproductive toxicity of test chemical in female Sprague-Dawley Rats by Uterotropic Activity
- GLP compliance:
- not specified
- Limit test:
- no
- Specific details on test material used for the study:
- - Name of test material: 2-octanone
- IUPAC name: octan-2-one
- Molecular formula: C8H16O
- Molecular weight: 128.2134 g/mol
- Substance type: Organic
- Physical state: Liquid
- Impurities (identity and concentrations): No data available - Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Zivic Miller, Allison Park, Pa.
- Age at study initiation: No data available.
- Fasting period before study: No data available.
- Housing: No data available.
- Diet (e.g. ad libitum): Purina lab chow ad libitum
- Water (e.g. ad libitum): water ad libitum - Route of administration:
- oral: gavage
- Type of inhalation exposure (if applicable):
- not specified
- Vehicle:
- CMC (carboxymethyl cellulose)
- Details on exposure:
- DOSAGE PREPARATION (if unusual): Test compound was suspended in 1% carboxymethylcellulose- H20 (1% CMC) and homogenized
VEHICLE
- Concentration in vehicle:10 mg/kg
- Amount of vehicle (if gavage): No data
- Justification for choice of vehicle: 1% carboxymethylcellulose- H20 (1% CMC)
- Lot/batch no. (if required):
- Purity: - Details on mating procedure:
- No data available
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- 3 days
- Frequency of treatment:
- Daily
- Details on study schedule:
- A fertility test was conducted on Ovariectomized female Sprague-Dawley Rats by Uterotropic Activity for 3 days, The dose were administrated by oral gavage.
- Dose / conc.:
- 10 mg/kg diet
- No. of animals per sex per dose:
- Total no of animals-42 females
0 mg/kg/day-21 female rats
10 mg/kg/day-8 female rats
10 µg /k (positive contro)-13 female rats - Control animals:
- yes, concurrent vehicle
- Positive control:
- 17-Ethinylestradiol
- Parental animals: Observations and examinations:
- Clinical sign and Body weight was observed daily.
- Oestrous cyclicity (parental animals):
- No data available
- Sperm parameters (parental animals):
- No data available
- Litter observations:
- No data available
- Postmortem examinations (parental animals):
- The necropsy was performed after 3 days. The uterus was removed, trimmed, and weighed.
- Postmortem examinations (offspring):
- No data available
- Statistics:
- yes, Student's t test and standard deviation were measured.
- Reproductive indices:
- No data available
- Offspring viability indices:
- No data available
- Clinical signs:
- no effects observed
- Dermal irritation (if dermal study):
- not specified
- Mortality:
- not specified
- Body weight and weight changes:
- no effects observed
- Food consumption and compound intake (if feeding study):
- not specified
- Food efficiency:
- not specified
- Water consumption and compound intake (if drinking water study):
- not specified
- Ophthalmological findings:
- not specified
- Haematological findings:
- not specified
- Clinical biochemistry findings:
- not specified
- Urinalysis findings:
- not specified
- Behaviour (functional findings):
- not specified
- Immunological findings:
- not specified
- Organ weight findings including organ / body weight ratios:
- no effects observed
- Histopathological findings: non-neoplastic:
- not specified
- Histopathological findings: neoplastic:
- not specified
- Other effects:
- not specified
- Reproductive function: oestrous cycle:
- not specified
- Reproductive function: sperm measures:
- not specified
- Reproductive performance:
- no effects observed
- Description (incidence and severity):
- No uterotropic activities and change in uterus weight were observed in treated rats as compare to control
- Key result
- Dose descriptor:
- NOAEL
- Effect level:
- 10 mg/kg bw/day
- Based on:
- test mat.
- Sex:
- female
- Basis for effect level:
- organ weights and organ / body weight ratios
- reproductive performance
- Remarks on result:
- other: not specified
- Critical effects observed:
- not specified
- System:
- other: not specified
- Organ:
- not specified
- Clinical signs:
- not specified
- Dermal irritation (if dermal study):
- not specified
- Mortality:
- not specified
- Body weight and weight changes:
- not specified
- Food consumption and compound intake (if feeding study):
- not specified
- Food efficiency:
- not specified
- Water consumption and compound intake (if drinking water study):
- not specified
- Ophthalmological findings:
- not specified
- Haematological findings:
- not specified
- Clinical biochemistry findings:
- not specified
- Urinalysis findings:
- not specified
- Behaviour (functional findings):
- not specified
- Immunological findings:
- not specified
- Organ weight findings including organ / body weight ratios:
- not specified
- Gross pathological findings:
- not specified
- Neuropathological findings:
- not specified
- Histopathological findings: non-neoplastic:
- not specified
- Histopathological findings: neoplastic:
- not specified
- Other effects:
- not specified
- Reproductive function: oestrous cycle:
- not specified
- Reproductive function: sperm measures:
- not specified
- Reproductive performance:
- not specified
- Dose descriptor:
- other: not specified
- Based on:
- not specified
- Sex:
- not specified
- Basis for effect level:
- other: not specified
- Remarks on result:
- other: not specified
- Critical effects observed:
- not specified
- System:
- other: not specified
- Organ:
- not specified
- Clinical signs:
- not specified
- Dermal irritation (if dermal study):
- not specified
- Mortality / viability:
- not specified
- Body weight and weight changes:
- not specified
- Food consumption and compound intake (if feeding study):
- not specified
- Food efficiency:
- not specified
- Water consumption and compound intake (if drinking water study):
- not specified
- Ophthalmological findings:
- not specified
- Haematological findings:
- not specified
- Clinical biochemistry findings:
- not specified
- Urinalysis findings:
- not specified
- Sexual maturation:
- not specified
- Organ weight findings including organ / body weight ratios:
- not specified
- Gross pathological findings:
- not specified
- Histopathological findings:
- not specified
- Other effects:
- not specified
- Behaviour (functional findings):
- not specified
- Developmental immunotoxicity:
- not specified
- Dose descriptor:
- other: not specified
- Generation:
- other: not specified
- Based on:
- not specified
- Sex:
- not specified
- Basis for effect level:
- other: not specified
- Remarks on result:
- not measured/tested
- Critical effects observed:
- not specified
- System:
- other: not specified
- Organ:
- not specified
- Clinical signs:
- not specified
- Dermal irritation (if dermal study):
- not specified
- Mortality / viability:
- not specified
- Body weight and weight changes:
- not specified
- Food consumption and compound intake (if feeding study):
- not specified
- Food efficiency:
- not specified
- Water consumption and compound intake (if drinking water study):
- not specified
- Ophthalmological findings:
- not specified
- Haematological findings:
- not specified
- Clinical biochemistry findings:
- not specified
- Urinalysis findings:
- not specified
- Sexual maturation:
- not specified
- Organ weight findings including organ / body weight ratios:
- not specified
- Gross pathological findings:
- not specified
- Histopathological findings:
- not specified
- Other effects:
- not specified
- Behaviour (functional findings):
- not specified
- Developmental immunotoxicity:
- not specified
- Dose descriptor:
- other: not specified
- Based on:
- not specified
- Sex:
- not specified
- Basis for effect level:
- other: not specified
- Remarks on result:
- not measured/tested
- Critical effects observed:
- not specified
- System:
- other: not specified
- Organ:
- not specified
- Reproductive effects observed:
- not specified
- Treatment related:
- not specified
- Conclusions:
- NOAEL was considered to be 10 mg/kg bw /day for P generation when Sprague-Dawley female rat were treated with test chemical daily for 3 days.
- Executive summary:
In an uterotropic activity study,Sprague-Dawley female rat were treated with test chemical in the concentration of 10 mg/kg in 1% carboxymethylcellulose- H20 (1% CMC) and homogenized and administrated orally by gavage dailyfor days which were ovariectomized before dosing. No toxic clinical sign and change in body weight were observed in treated female rats at 10 mg/kg as compared to control. In addition, no uterotropic activities and change in uterus weight were observed in treated rats as compare to control. Therefore, NOAEL was considered to be 10 mg/kg bw /day for P generation when Sprague-Dawley female rat were treated with test chemical daily for 3 days.
Reference
No uterotropic activities and change in uterus weight were observed in treated rats as compare to control
Effect on fertility: via oral route
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- NOAEL
- 1 000 mg/kg bw/day
- Study duration:
- subacute
- Species:
- rat
- Quality of whole database:
- Data is Klimiach 2 and from Peer- reviewed journal
Effect on fertility: via inhalation route
- Endpoint conclusion:
- no study available
Effect on fertility: via dermal route
- Endpoint conclusion:
- no study available
Additional information
Reproductive toxicity study
Data available from different studies were reviewed to determine the reproductive toxicity of testchemical.The studies are as mentioned below:
Study 1
In an uterotropic activity study, Sprague-Dawley female rat were treated with test chemical in the concentration of 10 mg/kg in 1% carboxymethylcellulose- H20 (1% CMC) and homogenized and administrated orally by gavage dailyfor days which were ovariectomized before dosing. No toxic clinical sign and change in body weight were observed in treated female rats at 10 mg/kg as compared to control. In addition, no uterotropic activities and change in uterus weight were observed in treated rats as compare to control. Therefore, NOAEL was considered to be 10 mg/kg bw /day for P generation when Sprague-Dawley female rat were treated with test chemical daily for 3 days. The study does not conclude higher dose value. Hence it is acceptable to take such low NOAEL .
Study 2
The reproductive and developmental toxicity study of test material was performed in female COBS CD rats. The test material was dissolved in corn oil and administered in dose concentration 0,200,1000mg/kg bw by oral gavage route from days 6-15 of gestation. 25 females /dose group were used in study. All the animals were observed for Clinical signs, body weight and food consumption. The dams were sacrificed and sectioned on gestation day 20. Intrauterine survival, foetal weight and external, skeletal and visceral anomalies were recorded. In dams clinical signs of intoxication were observed also reduced body weight was observed at 1000mg/kg bw dose group. Effects on the foetus were confined to an increase in numbers of litters with the skeletal variant 'malaligned sternebrae' which occurred at 200 mg/kg/day only and a slight decrease in foetal weight at 1000 mg/kg/day which was within the historical control range. As an increased incidence of 'malaligned sternebrae' was not observed at 1000 mg/kg/day the observation at 200 mg/kg/day was considered incidental. Hence the no observed adverse effect level (NOAEL) was considered to be 1000mg/kg bw/day for reproductive and developmental toxicity .When female rats were treated with test material by orally during gestation days 6-15.
Study 3
The reproductive and developmental toxicity study of test material was performed on female wistar rats.The chemicals were freshly prepared for gavage administration every day in aqueous emulsions under rapid stirring in doubly-distilled water containing approximately 0.005% Cremophor EL". The test material in dose concentration0,130,650,975,1300mg/kg day was adminstered fromday 6 to day 15 post-coitum (pc). Two control groups, treated with doubly-distilled water alone (1) or water plus approximately 0.005% Cremophor EL as emulsifier (2), were employed. one to four untreated females were mated with one untreated fertile male of the same breed. Mating took place overnight. If sperm was detected microscopically in the vaginal smears in the morning, the animals were considered to be fertilized. This day was designated as 'day 0' (beginning of the study) and the following day 'day 1' post-coitum (pc).Food consumption, body weights and clinical signs were recorded daily throughout the study. On day 20 pc all surviving females were killed and subjected to gross pathology. The foetuses were dissected from the uterus, weighed and further investigated for external, visceral and skeletal findings. Approximately one-half of the foetuses of all groups was fixed in Bouin's solution and examined according to the method of Barrow and Taylor (1969). For skeletal findings approximately one-half of the foetuses was fixed in ethyl alcohol and stained according to a modified method of Dawson (1926).
A dose-related increase in maternal toxicity with increasing severeness of clinical signs (lateral and abdominal position, unsteady gait, salivation, piloerection, nasal discharge and pneumonia) was observed. A slight decrease in food consumption and body weight gain was observed at650,975,1300mg/kg day dose group. Uterine and placental weights, foetal weights and data were not influenced by administration of this material. No dead foetuses were observed. There was no indication of developmental toxicity. All foetal values were within the range of biological variation; any differences in malformations and retardations were statistically insignificant or without a dose-response relationship and mostly occurred in animals of the treated and untreated groups as well as the historical control group at comparable frequency. A single cheiloschisis and one anophthalmy in the 1300mg/kg bw dose group was considered coincidental and not biologically significant. Hence the no observed adverse effect level (NOALE) was considered to be 1300mg/kg bw/day for reproductive and developmental toxicity .When female rats were treated with test material orally during gestation day 6-15.
Study 4
In a chronic toxicity study, Charles River CD, COBS male rats treated with test chemical orally by gavage in the concentration of 0 and 2000 mg/kg. Peripheral neuropathy, Hind limb weakness, reduction in extension of the hind limbs, a tendency for the tail to be carried low or to droop. Dragging of at least one hind paw was observed intermittently in treated rats as compared to control. The observed sign were considered to be neurotoxic signs. Minor decrease in food consumption was observed during weeks 1, 10 and 12 in treated rats as compared to control. No effects were observed on body weight, hematology and clinical chemistry of treated rats as compared to control.Significant increased in absolute and relative liver and relative adrenal gland, renal and brain weights and significant decrase in absolute brain and heart weights were observed in treated rats as compared to control. Statically Significant increased in absolute and relative testes weight were observed in treated male rats as compared to control. In addition, generalized adipose tissue atrophy and hind limb musculature atrophy were observed in treated rats. Flaccidity, pallor, and reduction in total muscle mass were evident in affected muscles. Hepatocyte hypertrophy and increased hyalin droplet formation in the proximal renal tubular epithelium, higher incidence of regenerating renal tubular epithelium and tubular dilation with casts were observed in treated rats. Muscle fiber atrophy was present in tongue, quadriceps femoris, calf, and hindpaw interosseous muscles. “Giant” axons and degenerating axons were located in intramuscular nerves. Sites of axonal damage in increasing order of severity were the cerebellum, medulla oblongata, spinal cord and peripheral nerves. Therefore, LOAEL was considered to be 2000 mg /kg r when Charles River CD, COBS male rats treated with test chemical orally.
Based on the data available from different studies, test material did not showedreproductive toxicityat dose concentration 1000 mg/kg /day. When male and female rats were treated with test material orally,thus, comparing this value with the criteria ofCLP regulationtest materialis not likelyto classify as reproductive toxicant.
Effects on developmental toxicity
Effect on developmental toxicity: via oral route
- Endpoint conclusion:
- no study available
Effect on developmental toxicity: via inhalation route
- Endpoint conclusion:
- no study available
Effect on developmental toxicity: via dermal route
- Endpoint conclusion:
- no study available
Toxicity to reproduction: other studies
Description of key information
Toxicity to Reproduction: Other route
NOAEL was considered to be 50 mg/kg bw /day for P and F1 generation when CF-1 female mice were treated with test chemical daily approx 19.4(gestation days) days.
Link to relevant study records
- Endpoint:
- toxicity to reproduction: other studies
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data is from peer reviewed publication
- Qualifier:
- according to guideline
- Guideline:
- other: No data
- Principles of method if other than guideline:
- To evaluate the Antifertility Activities of test chemical in female CF1 mice.
- GLP compliance:
- not specified
- Type of method:
- in vivo
- Specific details on test material used for the study:
- - Name of test material: 2-octanone
- IUPAC name: octan-2-one
- Molecular formula: C8H16O
- Molecular weight: 128.2134 g/mol
- Substance type: Organic
- Physical state: Liquid
- Impurities (identity and concentrations): No data available - Species:
- mouse
- Strain:
- CD-1
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- - Source: Carworth Farms
- Diet (e.g. ad libitum):Purina lab chow, ad libitum
- Water (e.g. ad libitum):water ad libitium - Route of administration:
- intraperitoneal
- Type of inhalation exposure (if applicable):
- not specified
- Vehicle:
- CMC (carboxymethyl cellulose)
- Remarks:
- 1 %
- Details on exposure:
- DOSAGE PREPARATION (if unusual): Test compound was suspended in 1% carboxymethylcellulose- H20 (1% CMC) and homogenized
VEHICLE
- Concentration in vehicle:50 mg/kg
- Amount of vehicle (if gavage): No data
- Justification for choice of vehicle: 1% carboxymethylcellulose- H20 (1% CMC)
- Lot/batch no. (if required):
- Purity: - Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- approx 19.4(gestation days) days.
- Frequency of treatment:
- Daily
- Duration of test:
- approx 19.4(gestation days) days.
- Dose / conc.:
- 50 mg/kg bw/day
- No. of animals per sex per dose:
- Total no of animals-78 females
0 mg/kg/day-62 female rats
50 mg/kg/day-8 female rats
Diethyl stilbestrol: -8 female rats - Control animals:
- yes, concurrent vehicle
- Details on study design:
- Diethyl stilbestrol was used as positive control.
- Statistics:
- Yes, Student's t test and standard deviation were measured
- Dose descriptor:
- NOAEL
- Effect level:
- 50 mg/kg bw/day
- Based on:
- test mat.
- Sex:
- female
- Basis for effect level:
- body weight and weight gain
- clinical signs
- other: No effect on Number of reabsorption sites and dead in utero per litter, viable foetuses per litter
- Conclusions:
- NOAEL was considered to be 50 mg/kg bw /day for P and F1 generation when CF-1 female mice were treated with test chemical daily approx 19.4(gestation days) days.
- Executive summary:
In an antifertility activity study, CF-1 female mice were treated with test chemical in the concentration of 50 mg/kg in 1% carboxymethylcellulose- H20 (1% CMC) and homogenized and administrated daily by intraperitoneally. No toxic clinical sign and change in body weight were observed in treated female mice at 50 mg/kg as compared to control. In addition, no reproductive effect such as number of reabsorption sites, dead in utero per litter, percent pregnant and number of viable foetuses per litter as compare to control. Therefore, NOAEL was considered to be 50 mg/kg bw /day for P and F1 generation when CF-1 female mice were treated with test chemical daily.
Reference
Antifertility Activities of Aliphatic Analogs of test chemical in CF1 Mice
Sr no |
Compound |
N |
%pregnant |
% average no. of foetuses per littera |
% average no. of reabsorption sites per littera |
1 |
Control |
62 |
100 |
100±25 |
100±25 |
2 |
test chemical |
8 |
75 |
87 |
0 |
3 |
Diethyl stilbestrol |
8 |
0 |
0 |
0 |
aAverage number of foetuses for CF1 mice = 12 ±3 and average number of reabsorption = 0.48 ± 0.12 per litter.
These values are considered to be 100%.
Additional information
Toxicity to Reproduction: Other route
In a study, test chemical has been investigated for reproductive toxicity to a greater or lesser extent. Often are the studies based on in vivo experiments in rodents, i.e. most commonly in mice for test chemical .
In an antifertility activity study, CF-1 female mice were treated with test chemical in the concentration of 50 mg/kg in 1% carboxymethylcellulose- H20 (1% CMC) and homogenized and administrated daily by intraperitoneally. No toxic clinical sign and change in body weight were observed in treated female mice at 50 mg/kg as compared to control. In addition, no reproductive effect such as number of reabsorption sites, dead in utero per litter, percent pregnant and number of viable foetuses per litter as compare to control. Therefore, NOAEL was considered to be 50 mg/kg bw /day for P and F1 generation when CF-1 female mice were treated with test chemical daily.
Thus, based on the above study on test chemical , it can be concluded test chemical is likely to be non toxic to reproduction. Hence, test chemical can be “Not classified” for reproductive toxicity by other route.
Justification for classification or non-classification
Thus, based on the above studies for target as well as read across substance, it can be concluded is likely to be non toxic to reproduction. Hence, octan-2-one can be “Not classified” for reproductive toxicity.
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.