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EC number: 233-546-5 | CAS number: 10226-30-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Repeated dose toxicity: inhalation
Administrative data
- Endpoint:
- repeated dose toxicity: inhalation
- Remarks:
- combined repeated dose and reproduction / developmental screening
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 4 (not assignable)
Data source
Reference
- Reference Type:
- secondary source
- Title:
- Revised Robust Summaries for Ketone Bottoms ( KB4/KB3) CAS NO. 68990-20-5, Eastman Chemical Company,
- Author:
- Eastman Kodak Co.
- Year:
- 2 007
- Bibliographic source:
- USEPA HPV dossier,Eastman Chemical Company, page 221, 2007
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: OECD:TG- 421
- Principles of method if other than guideline:
- Combined repeated dose repro-devp. Screen of 2-Nonanone in Sprague-Dawley rats
- GLP compliance:
- not specified
- Limit test:
- yes
Test material
- Reference substance name:
- Nonan-2-one
- EC Number:
- 212-480-0
- EC Name:
- Nonan-2-one
- Cas Number:
- 821-55-6
- IUPAC Name:
- nonan-2-one
- Reference substance name:
- 2-Nonanone
- IUPAC Name:
- 2-Nonanone
- Test material form:
- other: Liquid
- Details on test material:
- - Name of test material (as cited in study report): 2-Nonanone
- Molecular formula (if other than submission substance): C9H18O
- Molecular weight (if other than submission substance): 142.24g/mol
- Substance type: Organic
- Physical state: Liquid
- Impurities (identity and concentrations): 99%.
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- No data available.
Administration / exposure
- Route of administration:
- inhalation
- Type of inhalation exposure:
- not specified
- Vehicle:
- air
- Remarks on MMAD:
- MMAD / GSD: No data available
- Details on inhalation exposure:
- No data available.
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- 50 days
- Frequency of treatment:
- 6 hours/day, 7 days/week
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0, 78.6, 405.8 or 1022.6 ppm
Basis:
other: Actual exposure concentrations
- No. of animals per sex per dose:
- No data available
- Control animals:
- yes, concurrent vehicle
- Details on study design:
- No data available
- Positive control:
- No data available
Examinations
- Observations and examinations performed and frequency:
- CAGE SIDE OBSERVATIONS: No data available
DETAILED CLINICAL OBSERVATIONS: Yes
BODY WEIGHT: Yes
FOOD CONSUMPTION – Yes
AND COMPOUND INTAKE (if feeding study):
FOOD EFFICIENCY:
No data available
WATER CONSUMPTION AND COMPOUND INTAKE (if drinking water study): No data available
OPHTHALMOSCOPIC EXAMINATION: No data available
HAEMATOLOGY: Analysis of epididymal spermatozoan numbers and motility, and testicular spermatid head counts were determined.
CLINICAL CHEMISTRY: No data available
URINALYSIS: No data available
NEUROBEHAVIOURAL EXAMINATION: No data available
OTHER: Organ weight: The testes and epididymis were also weighed. - Sacrifice and pathology:
- GROSS PATHOLOGY: Yes HISTOPATHOLOGY: Yes, The ovaries, vagina, uterus, Fallopian tubes, and testes, epididymis, and male accessory sex organs were examined histologically.
- Statistics:
- Homogeneity of data were evaluated by Bartlett's test (p, 0.01), analysis of variance (ANOVA, <0.05), and Dunnett's test (p, 0.05). When the variances of the means were not considered equal by Bartlett's test, the data were evaluated by Kruskal-Wallis H-test (p, 0.05) followed by Mann-Whitney U-test (p<0.05). The reproductive performance of dams and fertility and fecundity indices were evaluated in contingency tables, using Chi-square test (p,0.05). The total number of pups per litter (live and dead) and the total number of live pups per litter were evaluated by a linear regression model.
Results and discussion
Results of examinations
- Clinical signs:
- effects observed, treatment-related
- Mortality:
- mortality observed, treatment-related
- Body weight and weight changes:
- no effects observed
- Food consumption and compound intake (if feeding study):
- effects observed, treatment-related
- Food efficiency:
- not specified
- Water consumption and compound intake (if drinking water study):
- not specified
- Ophthalmological findings:
- not specified
- Haematological findings:
- no effects observed
- Clinical biochemistry findings:
- not specified
- Urinalysis findings:
- not specified
- Behaviour (functional findings):
- not specified
- Organ weight findings including organ / body weight ratios:
- no effects observed
- Gross pathological findings:
- no effects observed
- Histopathological findings: non-neoplastic:
- no effects observed
- Details on results:
- Mortality-No mortality was observed in any group .
Clinical sign- Except for minimal reductions in activity level observed in the 400 and 1000 ppm groups during each exposure, no other test substance-related clinical abnormalities were noted.
Body weight and weight gain Body weight: There were no test substance-related changes in mean terminal body weight, mean body weight, body weight gain in treated group when compared to control.
Food consumption: For the 1000 ppm male group, there was a reduction in food consumption during days 0-7.
Food efficiency: No data available
Water consumption and compound intake: No data available
Opthalmoscopic examination No data available
Haematology No significant change were observed in Mean sperm motility and mean epididymal spermatozoan and testicular spermatid counts in treated group when compared to control group.
Clinical chemistry: No data available
Urinanalysis: No data available
Neurobehaviour: No data available
Organ weights No test substance-related significant change were observed in organ weight in treated group when compared to control group.
Gross pathology: No test substance-related significant change were observed in organ weight in treated group when compared to control group.
Histopathology: No exposure-related changes were observed during histological examination of the reproductive organs of any of the test substance-exposed parental male and female rats.
Details on results@ Embryotic / teratogenic effect and details- There were no treatment-related changes in pup clinical signs, weight gain, or abnormalities compared to controls at any of the test concentrations.
Effect levels
- Dose descriptor:
- NOAEL
- Effect level:
- 80 mg/L air
- Based on:
- test mat.
- Sex:
- male/female
- Basis for effect level:
- other: No test substance-related clinical sign , body weight,food consumption , gross and histopathological abnormalities
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
- Conclusions:
- NOAEL were found to be 80 mg/L for 2-Nonanone by inhalation route.
- Executive summary:
In Combined repeated dose repro-devp. Screen study for 2-Nonanone by inhalation route for 6 hours/ day for a week was observed in male and female Sprague-Dawley rats .They were exposed in concentration of 0, 80, 400, or 1000 ppm.Males were exposed for 50 days; females were exposed for 34-47 days (through day 19 of gestation).The ovaries, vagina, uterus, Fallopian tubes, and testes, epididymis, and male accessory sex organs were examined histologically. The testes and epididymis were also weighed. The study design also included an analysis of epididymal spermatozoan numbers and motility, and testicular spermatid head counts.All adult animals survived to study termination and there were no test substance-related changes in mean terminal body weight. For the 1000 ppm male group, there was a reduction in food consumption during days 0-7. Otherwise, there were no other differences in mean body weight, body weight gain, food consumption or food utilization among the groups throughout the study. Except for minimal reductions in activity level observed in the 400 and 1000 ppm groups during each exposure, no other test substance-related clinical abnormalities were noted. Mean sperm motility and mean epididymal spermatozoan and testicular spermatid counts were comparable among the groups. No test substance-related gross pathology was observed for adult animals from any group. No exposure-related changes were observed during histological examination of the reproductive organs of any of the test substance-exposed animals.There were no treatment-related changes in pup clinical signs, weight gain, or abnormalities compared to controls at any of the test concentrations.Therefore NOAEL were found to be 80 mg/L for2-Nonanone by inhalation route.
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