Registration Dossier
Registration Dossier
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EC number: 233-059-8 | CAS number: 10026-12-7
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Publication, which meets generally accepted scientifc standards
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- publication
- Title:
- Toxicological Studies of Niobium and Zirconium chlorides
- Author:
- Zhilova N.A. and Kasparov A.A.
- Year:
- 1 966
- Bibliographic source:
- Hygiene and Sanitation 31(7-9): 328-330
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Study is an acute oral toxicity, but as the study is from 1966 no OECD guideline for acute oral toxicity was available at that time
- GLP compliance:
- no
- Test type:
- other: acute oral toxicity
- Limit test:
- no
Test material
- Reference substance name:
- Niobium pentachloride
- EC Number:
- 233-059-8
- EC Name:
- Niobium pentachloride
- Cas Number:
- 10026-12-7
- Molecular formula:
- Cl5Nb
- IUPAC Name:
- Niobium(V) chloride
- Test material form:
- not specified
- Details on test material:
- - Name of test material (as cited in study report): niobium pentachloride
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- no detailed information provided
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- other: vaseline oil
- Details on oral exposure:
- no data provided
- Doses:
- no data provided
- No. of animals per sex per dose:
- no data provided
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: no data
- Necropsy of survivors performed: no data
- Other examinations performed: no data - Statistics:
- N.A.
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 829 mg/kg bw
- Based on:
- test mat.
- Mortality:
- Mortality occured, but no detailed information provided
Applicant's summary and conclusion
- Interpretation of results:
- Toxicity Category IV
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- In conclusion, the oral LD50 value in mice after treatment with niobium pentachloride was 829 mg/kg body weight.
- Executive summary:
In an acute oral toxicity study mice were orally exposed to niobium pentachloride in vaseline oil. Animals were observed for 14 days. Based on the results, the oral LD50 was considered to be 829 mg/kg body weight.
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