Registration Dossier
Registration Dossier
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EC number: 202-179-2 | CAS number: 92-69-3
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Materials and methods
- GLP compliance:
- yes (incl. QA statement)
- Type of study:
- mouse local lymph node assay (LLNA)
Test material
- Reference substance name:
- Biphenyl-4-ol
- EC Number:
- 202-179-2
- EC Name:
- Biphenyl-4-ol
- Cas Number:
- 92-69-3
- Molecular formula:
- C12H10O
- IUPAC Name:
- [1,1'-biphenyl]-4-ol
Constituent 1
In vivo test system
Test animals
- Species:
- mouse
- Strain:
- other: CBA/J Rj
- Sex:
- female
Results and discussion
In vivo (LLNA)
Results
- Parameter:
- SI
- Remarks on result:
- other: Negative control DMF: 1.0 P-PP 50 (w/v)% in DMF: 6.5 P-PP 25 (w/v)% in DMF: 4.6 P-PP 10 (w/v)% in DMF: 3.3 Positive control 25% -HCA in DMF: 15.8
Applicant's summary and conclusion
- Interpretation of results:
- Category 1B (indication of skin sensitising potential) based on GHS criteria
- Conclusions:
- The substance p-phenylphenol showed skin sensitizing potential in an in vivo LLNA test.
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