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Diss Factsheets
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EC number: 201-058-1 | CAS number: 77-78-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on developmental toxicity
Additional information
Type:Developmental or Reproductive Toxicity
Species: pregnant rats BD
Doses: single iv injection of 20 mg DMS/kg body weight
Result: Among 59 offspring, observed for more than 1 year, 7
developed malignant tumors, including 3 tumors of the brain (at 466,
732, and 907 days). Other tumors included 1 adenoma of the thyroid, 2
hepatic-cell carcinomas, and 1 carcinoma of the uterus.
Reference: IPCS INCHEM;
Environmental Health Criteria (EHC) Monographs. Dimethyl sulfate (EHC
48, 1985). Available from, as ofOctober
1, 2007:
http://www.inchem.org/pages/ehc.html
Type: Developmental or Reproductive Toxicity
Species: pregnant Crl:CD BR rats
Route of exposure: inhalation (nose-only)
Result: Rats were exposed to 0.1, 0.7 or 1.5ppm dimethyl
sulfate (DMS) for 6 hr/day from Days 7 through 16 of gestation
(day in which copulation plug was detected was designated Day 1G). A
control group of pregnant rats was exposed simultaneously to air only.
All female rats were euthanized on Day 22G and the fetuses were
examined. A suppression of both food consumption and the rate of body
weight gain were seen in the 0.7 and 1.5 ppm groups. No unusual clinical
signs were seen in rats exposed to DMS. None of the reproductive
parameters was altered in any of the groups and no statistically
significant fetal effects were detected. DMS is not a developmental
toxicant in the rat following inhalation exposures up to 1.5 ppm during
the period of major organogenesis.
Reference: Alvarez et al; Drug
Chem Toxicol 20 (1-2): 99-114 (1997)PubMed
Abstract
Type: Developmental or Reproductive Toxicity
Reference: American Conference of Governmental Industrial Hygienists, Inc. Documentation of the Threshold Limit Values and Biological Exposure Indices. 6th ed. Volumes I, II, III.Cincinnati,OH: ACGIH, 1991, p. 497.
Justification for classification or non-classification
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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