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EC number: 413-090-5 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Adsorption / desorption
Administrative data
Link to relevant study record(s)
- Endpoint:
- adsorption / desorption: screening
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 21 March 2006 to 22 March 2006
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.19 (Estimation of the Adsorption Coefficient (KOC) on Soil and Sewage Sludge Using High Performance Liquid Chromatography (HPLC))
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 121 (Estimation of the Adsorption Coefficient (Koc) on Soil and on Sewage Sludge using High Performance Liquid Chromatography (HPLC))
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- HPLC estimation method
- Media:
- soil/sewage sludge
- Radiolabelling:
- no
- Test temperature:
- 25 deg C
- Details on study design: HPLC method:
- Reagents
Methanol, Riedel de Haen
Potassium dihydrogen phosphate, Fluka
Cleaned water (laboratory equipment)
Distilled water, Roth
Dead time marker: Formamide, Merck
Calibration substances (Merck, Riedel de Haen)
Instruments
Chromatographic apparatus
Analytical balance, Sartorius, model R160 P
pH-meter, Mettler, model MP220
Variable pipettes, Brand
General laboratory glassware
Cleaned water plant, Elga
Chromatographic Conditions
Except for the detection wavelength the chromatographic conditions were the same for the determination of t0 the establishment of the calibration graph and the measurement of the test item.
HPLC Equipment: HPLC pump G1312A, autosampler G1313A, column oven G1316A, degaser G1322A and UVA/is detector G1315B by Agilent
Column: stationary phase: LiChrospher 100 CN 5um by Duratec (18704-02) material: stainless steel, dimensions: 125 mm x Ø 4.6 mm column temperature: 25 °C
Mobile Phase: 900 ml cleaned water + 100 ml KH2PO4 (c = 0.02 mol/l) / 900 ml methanol + 100 ml KH2PO4 (c = 0.02 mol/l) (70:30 % (v/v)), pH 8.1, isocratic elution
Flow rate: 1.0 ml/min
Injection volume: 10 μl
Detection wavelength: 210 nm (dead time marker, calibration substances)
270 nm (test item)
Injection amounts: Dead time marker: 22.6 μg
Calibration substances: 0.68 - 1.90 μg
Test item: 0.25 ug
The dead time marker was dissolved in mathanol and diluted 0.1 to 1 in the mobile phase and injected as single standards twice. The calibration substances were dissolved in methanol and diluted 0.1 to 1 in the mobile phase and injected as single standards twice. The item was dissolved in distilled water and diluted 0.1 to 1 in mobile phase and injected as single sample twice. - Analytical monitoring:
- not specified
- Details on sampling:
- Not applicable
- Details on matrix:
- Not applicable
- Details on test conditions:
- Not applicable
- Computational methods:
- Not applicable
- Type:
- Koc
- Value:
- < 1.3
- Temp.:
- 25 °C
- Remarks on result:
- other: Org. carbon data not referenced in report
- Details on results (HPLC method):
- Table 3: log Koc of the Test Item – 1. Measurement
Test item 1. Inj. tR in min k Log k Log Koc
Reaktiv Gelb F6872 FW 0.826 -0.54 <-0.23 <1.32
Table 5: log Koc of the Test Item – 2. Measurement
Test Item 2. Inj. tR in min k Log k Log Koc
Reaktiv Gelb F6872 FW 0.825 -0.54 <0.20 <1.32
Table 6: log Koc of the Test Item
Log Koc
1. Measurement <1.32
2. Measurement <1.32
Mean <1.32
Tables 1, 2 & 4 attached under any further information. - Adsorption and desorption constants:
- Not applicable
- Details on results (Batch equilibrium method):
- Not applicable
- Statistics:
- Not applicable
- Validity criteria fulfilled:
- yes
- Conclusions:
- The adsorption coefficient of the test item was found to be:
log Koc <1.3 - Executive summary:
The objective of this study was the determination of the adsorption coefficient K0c of the test item according to the consolidated version of Guideline 67/548/EEC Annex V,Part C.19.: estimation of the adsorption coefficient on soil and on sewage sludge using HPLC and OECD test guidelines 121: estimation of the adsorption coefficient on soil and on sewage sludge using HPLC. Study conducted in compliance with GLP.
The adsorption coefficient of the test item was determined according to the "HPLC- method".
The adsorption coefficient of the test item was found to be:
logKoc <1.3
The substance is not considered to have the potential to adsorb to soil / sediment within the environment.
Reference
Table 1: Determination of the Dead Time t0
Dead time marker |
tRin min 1. Measurement |
tRin min 2. Measurement |
tRin min Mean |
Formamide |
1.790 |
1.789 |
1.790 |
Dead time: t0= 1.790 min
Table 2: Calibration Data – 1. Measurement
Calibration Substance |
1. Inj. tRin min |
k |
Log k |
Log Koc* |
Acetanilide |
3.054 |
0.71 |
-0.15 |
1.25 |
Phenole |
2.846 |
0.59 |
-0.23 |
1.32 |
Atrazin |
4.545 |
1.54 |
0.19 |
1.81 |
Monuron |
4.590 |
1.56 |
0.19 |
1.99 |
Triadimenol |
8.837 |
3.94 |
0.60 |
2.40 |
Linuron |
9.767 |
4.46 |
0.65 |
2.59 |
Naphthalene |
10.780 |
5.02 |
0.70 |
2.75 |
(*from OECD guideline 121)
Regression: logKoc= a + b x log k
Parameters: a= 1.59
b= 1.54
r2= 0.9760
Table 4: Calibration Data – 2. Measurement
Calibration substance |
2. Inj. tRin min |
k |
Log k |
Log Koc* |
Acetanilide |
3.072 |
0.72 |
-0.14 |
1.25 |
Phenole |
2.856 |
0.60 |
-0.20 |
1.32 |
Atrazin |
4.465 |
1.55 |
0.19 |
1.81 |
Monuron |
4.597 |
1.57 |
0.20 |
1.99 |
Triadimenol |
8.833 |
3.94 |
0.60 |
2.40 |
Linuron |
9.754 |
4.45 |
0.65 |
2.59 |
Naphthalene |
10.753 |
5.01 |
0.70 |
2.75 |
(*from OECD guideline 121)
Regression: logKoc= a + b x log k
Parameters: a= 1.58
b= 1.55
r2=0.9754
Description of key information
The adsorption coefficient of the test item was found to be: log Koc <1.3
Key value for chemical safety assessment
Other adsorption coefficients
- Type:
- other: Koc
- Value in L/kg:
- 19.953
- at the temperature of:
- 25 °C
Additional information
The objective of this study was the determination of the adsorption coefficient K0c of the test item according to the consolidated version of Guideline 67/548/EEC Annex V,Part C.19.: estimation of the adsorption coefficient on soil and on sewage sludge using HPLC and OECD test guidelines 121: estimation of the adsorption coefficient on soil and on sewage sludge using HPLC. Study conducted in compliance with GLP.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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