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EC number: 252-488-1 | CAS number: 35285-69-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Apr - June 1982
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Well reported study, performance equivalent to OECD Guideline 401 with some minor restrictions.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 982
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- no
- Remarks:
- Necropsy was not performed in all surviving animals
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Sodium 4-propoxycarbonylphenoxide
- EC Number:
- 252-488-1
- EC Name:
- Sodium 4-propoxycarbonylphenoxide
- Cas Number:
- 35285-69-9
- Molecular formula:
- C10H12O3.Na
- IUPAC Name:
- propyl 4-hydroxybenzoate
- Test material form:
- other: solid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Winkelmann, Borchen, Germany
- Age at study initiation: 9 - 14 weeks
- Weight at study initiation: 176 g (males), 176 g (females)
- Fasting period before study: Animals were fasted from 16 h before application until 4 h after application. During this period tap water was available.
- Housing: Groups of five animals were housed in Makrolon cages type III with dustfree wood pellets as bedding material.
- Diet: Altromin R 1324, Altromin GmbH, Germany, ad libitum
- Water: tap water, ad libitum
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 ± 1,5
- Humidity (%): 60 ± 5
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- MAXIMUM DOSE VOLUME APPLIED: 20 mL/kg bw
- Doses:
- 1000, 3100 or 5000 mg/kg bw (females)
3100 or 5000 mg/kg bw (males) - No. of animals per sex per dose:
- 10
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 d
- Frequency of observations and weighing: Animals were periodically observed for clinical signs on the treatment day and twice daily thereafter until the end of the observation period. Body weights were recorded right before application and weekly thereafter.
- Necropsy of survivors performed: yes, on a random basis
- Other examinations performed: clinical signs
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Remarks on result:
- other: 7/20 animals died at 5000 mg/kg bw (5 females and 2 males)
- Mortality:
- No mortality occurred in the 1000 mg/kg bw group. In the 3100 mg/kg bw group, 1/10 females died during the first day after application of the test substance. In the 5000 mg/kg bw group, 2/10 males and 5/10 females were found dead during the first 3 days after application of the test substance.
- Clinical signs:
- other: Clinical signs were observed at 3100 mg/kg bw (females) and higher or at 5000 mg/kg bw (males). The general condition of all animals was decreased. They showed signs of sedation and anaesthesia. These symptoms were (almost) fully reversible within 7 days
- Gross pathology:
- Necropsy of surviving animals on a radom basis revealed no substance-related findings. No necropsy or histopahological examination was done in the animals that died during the observation period.
Applicant's summary and conclusion
- Interpretation of results:
- other: CLP/EU GHS criteria not met, no classification required according to Regulation (EC) No 1272/2008
- Conclusions:
- The median lethal dose of the test substance (LD50) was greater than 5000 mg per kg body weight. Based on the result of this study the substance is not subject for labelling and classification requirements according to regulatory requirements.
- Executive summary:
The potential acute oral toxicity of sodium 4-propoxycarbonylphenoxide (CAS 35285-69-9) was assessed in a study performed according to a protocol similar to OECD 401 (Bayer, 1982). 10 rats/sex were administered 1000 (only in females), 3100 and 5000 mg/kg bw of the test substance by gavage. No mortality occurred in the 1000 mg/kg bw group. In the 3100 mg/kg bw group, 1/10 females died during the first day after application of the test substance. In the 5000 mg/kg bw group, 2/10 males and 5/10 females were found dead during the first 3 days after application of the test substance. Clinical signs were observed at 3100 mg/kg bw (females) and higher or at 5000 mg/kg bw (males). The general condition of all animals was decreased. Signs of sedation and anaesthesia were observed. These symptoms were (almost) fully reversible within 7 days (females) or 2 days (males). Necropsy in surviving animals on random basis revealed no substance related findings. Based on the results of the conducted study, the oral LD50 value is considered to be > 5000 mg/kg bw .
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