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EC number: 810-201-2 | CAS number: 1050477-27-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 111 (Hydrolysis as a Function of pH)
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- EU Method C.7 (Degradation: Abiotic Degradation: Hydrolysis as a Function of pH)
- GLP compliance:
- no
- Radiolabelling:
- no
- Analytical monitoring:
- yes
- Details on sampling:
- - pH of the blank buffer solution: checked at the beginning of the test
- pH of the hydrolysis solution: measured at each test point
- Temperature during the experiment: checked at each test point
- repeatability of the peak areas of the investigated components was checked by analyzing an independent control solution of the test item; peak areas of the three components investigated within this hydrolysis study were measured and compared
- suitability of the HPLC system during the hydrolysis study was verified on every day of application
- calibration was verified at each sampling date at the level of 4.94 mg/L by using a control calibration solution - Buffers:
- - Buffer pH 4: Citric acid/NaOH/NaCl (Fluka, order no.: 33643)
- Buffer pH 7: KH2PO4/Na2HPO4 (Fluka, order no.: 33646)
- Buffer pH 9: Na2B4O7/HCl (Fluka, order no.: 33648) - Details on test conditions:
- Preparation of a test item stock solution
- weighing of 22.3 mg of the test item in a 100 mL measuring flask which was then filled to the mark with acetonitrile, resulting in a final concentration of 223 mg/L
Preparation of the hydrolysis test solutions
- For each pH separate hydrolysis test solutions were prepared by dilution of 2 mL of the test item stock solution with 200 mL of the corresponding buffer systems. Test item concentrations of 9.0 mg/L were obtained.
- test item was applied as an aqueous solution (including 1 % acetonitrile) with a concentration of approx. 9 mg/L (water solubility estimated in a non-GLP pretest: 20 mg/L)
- Aliquots of the stock solutions were taken without further treatment to prepare individual vials for every test point
- Preparation was carried out under nitrogen as flushing gas
- vials were closed and incubated at 20 °C in a water bath under dark conditions
- at each test point the hydrolysis solution was directly led to the chromatographic measurement
- pH determination: pH-meter equipped with a calibrated single-rod glass electrode - Duration:
- 5 d
- pH:
- 4
- Temp.:
- 20 °C
- Initial conc. measured:
- 8.952 mg/L
- Duration:
- 5 d
- pH:
- 7
- Temp.:
- 20 °C
- Initial conc. measured:
- 8.819 mg/L
- Duration:
- 5 d
- pH:
- 9
- Temp.:
- 20 °C
- Initial conc. measured:
- 8.726 mg/L
- Transformation products:
- no
- % Recovery:
- 94.9
- pH:
- 4
- Temp.:
- 20 °C
- Duration:
- 5 d
- % Recovery:
- 96.7
- pH:
- 7
- Temp.:
- 20 °C
- Duration:
- 5 d
- % Recovery:
- 98.3
- pH:
- 9
- Temp.:
- 20 °C
- Duration:
- 5 d
- Details on results:
- Rac-Amido-TH-naphthyridine is found to be stable at 20 °C at all three pH-values for 5 days. No half-life times and hydrolysis rates were calculated. Because no degradation was observed, no sterility test was performed in this case.
- Validity criteria fulfilled:
- yes
- Conclusions:
- Rac-Amido-TH-naphthyridin is found to be stable at 20 °C at all three pH-values for 5 days. No half-life times and hydrolysis rates were calculated.
- Executive summary:
The test was performed based on OECD Guidelines for Testing of Chemicals, Section 1 – Physical-Chemical Properties, OECD TG 111, Council Regulation (EC) No 440/2008, Guideline Part C – Methods for the Determination of Ecotoxicity, C.7. “Abiotic Degradation: Hydrolysis as a Function of pH”.
The hydrolysis behaviour of Rac-Amido-TH-naphthyridin was investigated at 20 °C at pH 4, pH 7 and pH 9 over a period of five days according to OECD TG 111. The stability was monitored by HPLC analysis using UV-detection.
No abiotic degradation of the test item was observed. Rac-Amido-TH-naphthyridin is found to be stable at 20 °C at all three pH-values for 5 days. No half-life times and hydrolysis rates were calculated.
Reference
Description of key information
Rac-Amido-TH-naphthyridin is found to be stable at 20 °C at all three pH-values for 5 days. No half-life times and hydrolysis rates were calculated.
Key value for chemical safety assessment
Additional information
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