Registration Dossier
Registration Dossier
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EC number: 500-047-1 | CAS number: 26316-40-5 1 - 4.8 moles ethoxylated and 1 - 8.5 moles propoxylated
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Comparable to guideline study with acceptable restrictions.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 982
- Report date:
- 1982
Materials and methods
- Principles of method if other than guideline:
- Method: other: Federal Register, 1978, 43, 37355-6, a standard acute method.
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Details on test material:
- EDA, EO + PO
Lot TB11170-841
Based on producers products specs information from the producer (not available in the report) the test material was 70–90% PO and 10–30% EO and has a Molecular Mass of (average Mn = 280 g/mol)
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Doses:
- 5000, 2500, 1250, 650
- No. of animals per sex per dose:
- 6
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
Any other information on results incl. tables
MORTALITY:
- Time of death: Not
documented
- Number of deaths at each dose: 1 male and 1 female in top does (5000
mg/kg).
CLINICAL
SIGNS:
Diarrhea and slight
tremors were observed in the rat that subsequently died. All surviving
rats appeared healthy and gained weight during the 2-week observation
period.
NECROPSY
FINDINGS: none
POTENTIAL TARGET ORGANS: not identified
SEX-SPECIFIC DIFFERENCES: not reported.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Oral LD50 of >5000 mg/kg: no EU classification for acute oral toxicity.
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