Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-474-9 | CAS number: 107-22-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
With high probability acutely not harmful to aquatic freshwater invertebrates. Acutely harmful to marine invertebrates.
Key value for chemical safety assessment
Marine water invertebrates
Marine water invertebrates
- Effect concentration:
- 42 mg/L
Additional information
The result of the key study on freshwater invertebrates (BASF, 1988) indicates no acute toxicity of glyoxal (40% in aqueous solution) to Daphnia magna. The EC50 value is above 100 mg/L even when it is considered that no analytical monitoring was performed since glyoxal was shown to be stable at least for this 48-h period.
With the marine invertebrate Americamysis bahia a GLP guideline study following EPA OPPTS 850.1035 (Mysid Acute Toxicity Test) is available. Based on mean measured concentrations, the 96 -h LC50 was 42.0 mg a.i./L (BASF, 2009), indicating a slightly higher toxicity towards marine organisms.
Additional data on acute toxicity to aquatic invertebrates are available from three studies with two glyoxal products of unknown composition (Parez 802 and CT-194, American Cyanamid Company). Parez 802 did not show harmful effects to Daphnia magna up to 1000 mg test mat./L (Surprenant, 1984a). The acute effects of CT-194 were tested on Daphnia magna in a 48 -h static study (Surprenant, 1984b) and on the marine shrimp Mysidopsis bahia in a 96-h static study (Irwin, 1994). When results with CT-194 are corrected for purity (assuming 40 % glyoxal in the product), the corresponding LC50 values are between 10 and 100 mg/L, indicating moderate toxicity. Hence, the product CT-194 appears to be of higher toxicity than glyoxal in aqueous solution alone. Similar to the fish acute toxicity the results with the products of unknown composition are not taken into consideration due to the unclear reliability.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.