Registration Dossier
Registration Dossier
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EC number: 201-143-3 | CAS number: 78-79-5
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation / corrosion, other
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Justification for type of information:
- See QMRF document in cross-reference.
Cross-reference
- Reason / purpose for cross-reference:
- (Q)SAR model reporting (QMRF)
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 2 005
- Report date:
- 2005
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 007
- Report date:
- 2007
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- QSAR Toolbox version 4.3.1 was used to assess skin irritation/corrosion potential using the BfR database.
Test material
- Reference substance name:
- Isoprene
- EC Number:
- 201-143-3
- EC Name:
- Isoprene
- Cas Number:
- 78-79-5
- Molecular formula:
- C5H8
- IUPAC Name:
- 2-methylbuta-1,3-diene
Constituent 1
Results and discussion
In vitro
Results
- Remarks on result:
- no indication of irritation
In vivo
- Irritant / corrosive response data:
- Skin irritation/corrosion Inclusion rules by BfR - Inclusion Rules Not Met
Skin irritation/corrosion Exclusion rules by BfR - Undefined
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Skin irritation/corrosion Inclusion rules by BfR - Inclusion Rules Not Met
Skin irritation/corrosion Exclusion rules by BfR - Undefined
These QSAR results indicate that isoprene should be "not classified" for skin irritation and corrosion - Executive summary:
Skin irritation/corrosion Inclusion rules by BfR - Inclusion Rules Not Met
Skin irritation/corrosion Exclusion rules by BfR - Undefined
These QSAR results indicate that isoprene should be "not classified" for skin irritation and corrosion
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