2-piperazin-1-ylethylamine

Skin irritation / corrosion

Administrative data

Endpoint:

skin irritation: in vivo

Type of information:

experimental study

Adequacy of study:

key study

Study period:

Not applicable

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: 2e: Meets generally accepted scientific standards, well-documented and acceptable for assessment

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1958

Report date:

1958

Materials and methods

Principles of method if other than guideline:

Conducted prior to OECD and EC guidelines

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

2-piperazin-1-ylethylamine

EC Number:

205-411-0

EC Name:

2-piperazin-1-ylethylamine

Cas Number:

140-31-8

Molecular formula:

C6H15N3

IUPAC Name:

2-piperazin-1-ylethanamine

Details on test material:

- Name of test material (as cited in study report): beta-Aminoethyl piperazine
- Molecular weight (if other than submission substance):
- Substance type:
- Physical state: light yellow liquid
- Analytical purity: > 98%
- Impurities (identity and concentrations):
- Composition of test material, percentage of components:
- Purity test date:
- Lot/batch No.: D9-1782
- Stability under test conditions:
- Storage condition of test material:
- Other: Solution - Greater then 25% water, acetone; 95% ethanol and benzene
- Melting Point: -17.69°C
-Boiling Point: 220°C at 760 mmHg

Test animals

Species:

rabbit

Strain:

not specified

Details on test animals or test system and environmental conditions:

No data

Test system

Type of coverage:

not specified

Preparation of test site:

not specified

Vehicle:

unchanged (no vehicle)

Controls:

no

Amount / concentration applied:

Not applicable

Duration of treatment / exposure:

Undiluted material was applied to the intact skin of a rabbit belly for 20 minutes.

Observation period:

Not applicable

Number of animals:

Not applicable

Details on study design:

Not applicable

Results and discussion

In vivo

Results

Results 1

Remarks on result:

other: The animal was sacrificed following first routine application due to severe damage to the belly.

Results 2

Irritation parameter:

edema score

Remarks:

ear

Basis:

animal #1

Time point:

24 h

Score:

1

Max. score:

4

Results 3

Irritation parameter:

edema score

Remarks:

intact abdomen

Basis:

animal #2

Time point:

24 h

Score:

4

Max. score:

4

Reversibility:

not reversible

Remarks on result:

other: Animal sacrificed - damage too great.

Results 4

Irritation parameter:

edema score

Remarks:

abraded abdomen

Basis:

animal #3

Time point:

24 h

Score:

4

Max. score:

4

Reversibility:

not reversible

Remarks on result:

other: Animal sacrificed - damage too great.

Results 5

Irritation parameter:

erythema score

Basis:

mean

Time point:

24/48/72 h

Remarks on result:

probability of severe irritation

Remarks:

animals 2 and 3 were sacrificed due to sever skin damage

Results 6

Irritation parameter:

edema score

Basis:

mean

Time point:

24/48/72 h

Remarks on result:

probability of severe irritation

Remarks:

animals 2 and 3 were sacrificed due to sever damage on the skin

Irritant / corrosive response data:

Not applicable

Other effects:

Slight hyperemia and necrosis was observed after a single application.

Any other information on results incl. tables

Not applicable

Applicant's summary and conclusion

Interpretation of results:

other: Severe damage to the belly

Conclusions:

The undiluted material has a severe effect upon intact skin. Contact to exposed skin for a matter of 15 or 20 minutes is likely to produce a mild burn. It is of utmost importance to avoid skin contact with the undiluted material.

Executive summary:

Not applicable