Acetone

Skin irritation / corrosion

Administrative data

Endpoint:

skin irritation: in vivo

Type of information:

experimental study

Adequacy of study:

supporting study

Reliability:

3 (not reliable)

Rationale for reliability incl. deficiencies:

other: see 'Remark'

Remarks:

Data from a compilation of data without detailed documentation of testing procedures and results; relevant methodological deficiencies: low test volume of 10 µL instead of 500 µL as standard condition, open application of the highly volatile compound, other scoring system; study not acceptable for classification

Cross-reference

Reason / purpose for cross-reference:

reference to same study

Data source

Reference

Reference Type:

review article or handbook

Title:

Range-finding toxicity data: List VI

Author:

Smyth HF, Carpenter CP, Weil CS, Pozzani UC, Striegel JA

Year:

1962

Bibliographic source:

Am Ind Hyg Assoc J 23: 95-107

Materials and methods

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

Open application of 10 µl volume, skin reaction scored on a 10-grade ordinal series (no further details)

Test material

Test material information

Constituent 1

Reference substance name:

Acetone

EC Number:

200-662-2

EC Name:

Acetone

Cas Number:

67-64-1

Molecular formula:

C3H6O

IUPAC Name:

propan-2-one

Test animals

Species:

rabbit

Strain:

other: Albino

Test system

Type of coverage:

open

Preparation of test site:

shaved

Vehicle:

unchanged (no vehicle)

Controls:

not specified

Amount / concentration applied:

TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.01 mL

Duration of treatment / exposure:

single

Observation period:

24 hrs

Number of animals:

5

Results and discussion

In vivo

Results

Irritation parameter:

overall irritation score

Basis:

other: animal showing severest reaction

Time point:

other: 24 hrs

Max. score:

1

Reversibility:

no data

Remarks on result:

other: grade 1 out of 10 indicating no irritation

Applicant's summary and conclusion

Interpretation of results:

not irritating

Remarks:

Migrated information Criteria used for interpretation of results: other: grade 1 out of 10 indicating no irritation

Conclusions:

Acetone (10 µl, open application) was not irritating to rabbit skin after 24 hours of uncovered application.

Executive summary:

10 µl of acetone were applied uncovered on the clipped skin of the bellies of 5 rabbits. Skin reaction was scored after 24 hours in a 10 grade ordinal series and was based upon the severest reaction observed. Grade 1 out of 10 indicated absence of skin irritation.