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EC number: 265-110-5 | CAS number: 64742-10-5 A complex combination of hydrocarbons obtained as the extract from a solvent extraction process. It consists predominantly of aromatic hydrocarbons having carbon numbers predominantly higher than C25.
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
For purposes of classification and labelling and registration under REACH, aromatic extracts are sub-divided into the categories of distillate aromatic extracts (DAE), treated distillate aromatic extracts (TDAE), and residual aromatic extracts (RAE). Some of the classifications are based on 3-7 ring PAC content, which is not substantively affected by whether the aromatic extract is derived from paraffinic or naphthenic or “light” or “heavy” crude. Therefore, DAEs and RAEs are not subclassified based on crude oil source or viscosity. For most health endpoints, data from any one of the DAEs can be “read-across” to the remaining DAEs and whole RAE category.
In a read-across dermal sensitisation study using light paraffinic distillate solvent extract in paraffin oil, 5 to 6 week old Hartley guinea pigs were tested in a Buehler test which is similar to OECD test guideline 406. 10 test guinea pigs were dosed with 0.4 mL 50% v/v in paraffin oil for 3 weeks (1 dose/week) and then a challenge dose of 0.4 mL 1% v/v in paraffin oil 2 weeks after the last test dose. A naïve control group of 10 animals remained untreated during induction, but received the same dose as the test animals during the challenge phase. A very slight erythema reaction was exhibited by 8 animals in the test group. These reactions did not exceed the highest reaction of the naïve control animals. The other two test animals exhibited no reaction.
Based upon the similar results obtained from the challenge phase and the naive control, RAEs are not sensitising to guinea pig skin according to EU criteria.
Migrated from Short description of key information:
Distillate aromatic extracts were found to be non-sensitising in Hartley guinea pigs when utilising the Buehler test (equivalent to OECD 406) and based on read across, RAEs are not expected to cause skin sensitisation.
Respiratory sensitisation
Endpoint conclusion
- Additional information:
Respiratory sensitisation is not a standard information requirement.
Migrated from Short description of key information:
No data identified.
Justification for classification or non-classification
Distillate aromatic extracts are not considered skin sensitisers based on the information presented above. Since read across from DAE is considered appropriate for this endpoint, RAEs do not meet the criteria for classification as a dermal sensitiser under CLP Regulation, (EC)1272/2008,
according to the read-across strategy.Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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