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Diss Factsheets
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EC number: 203-005-8 | CAS number: 102-09-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Additional ecotoxological information
Administrative data
- Endpoint:
- additional ecotoxicological information
- Type of information:
- (Q)SAR
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Report on a review of information generated using (Q)SAR tools with QMRF and QPRF reporting
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 010
- Report date:
- 2010
Materials and methods
- Principles of method if other than guideline:
- CRAFT (2009) and ECOSAR (2009) were used to investigate aspects relating to the environmental fate and ecotoxicity of diphenyl carbonate. First, the degradation products of diphenyl carbonate were predicted using CRAFT. Then, the degradation products were assessed in terms of their potential short-term aquatic toxicity to green algae.
- GLP compliance:
- no
- Type of study / information:
- Desk-based review of information generated through the use of (Q)SAR.
Test material
- Reference substance name:
- Diphenyl carbonate
- EC Number:
- 203-005-8
- EC Name:
- Diphenyl carbonate
- Cas Number:
- 102-09-0
- Molecular formula:
- C13H10O3
- IUPAC Name:
- diphenyl carbonate
Constituent 1
Results and discussion
Any other information on results incl. tables
Diphenyl carbonate degradation products anticipated as “very likely” using CRAFT are predicted by EPI Suite ECOSAR as likely to have a green algae (96h) EC50 >1 mg/L.
Diphenyl carbonate degradation products predicted by CRAFT that could be of potential concern to algae by EPI Suite ECOSAR concern benzene structures with multiple hydroxyl groups where there is a hydroxygroup in 1,4 positions (e.g. 4-hydroxycatechol). These structures are predicted by ECOSAR as having a green algae (96h) EC50 value slightly below 1 mg/L due to presence of quinone/hydroquinone structural similarities. However, using the example of hydroquinone, algae test study results of hydroquinone reported in the ex-ECB ESIS database (2010) indicated EC50 >1 mg/L (although ECOSAR predicts <1 mg/L). For hydroquinone it is fish and daphnia results that are <1 mg/L resulting in R50 classification. By comparison fish and daphnia studies for diphenyl carbonate are >1 mg/L.
Overall, diphenyl carbonate degradation products are expected to have rapid ring opening, resulting in products that are expected to have green algae (96h) values of EC50 >>1 mg.
Applicant's summary and conclusion
- Conclusions:
- Based on the review of the predicted degradation products, it is not expected that diphenyl carbonate would have a toxicity to green algae (96 h) below 1 mg/L. This can be considered together with other information on diphenyl carbonate.
- Executive summary:
Diphenyl carbonate degradation products anticipated as “very likely” using CRAFT are predicted by EPI Suite ECOSAR as having a green algae (96 h) EC50 >1 mg/L. Furthermore diphenyl carbonate degradation products are expected to have rapid ring opening, resulting in products that are expected to have green algae (96 h) values of EC50 >>1 mg. This information is deemed relevant for consideration as part of a weight-of-evidence during the classification and labelling of diphenyl carbonate.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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