Registration Dossier
Registration Dossier
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EC number: 200-664-3 | CAS number: 67-68-5
Additional ecotoxological information
Administrative data
- Endpoint:
- additional ecotoxicological information
- Type of information:
- experimental study
- Adequacy of study:
- other information
Data source
Reference
- Reference Type:
- publication
- Title:
- Acute toxicological effects of dimethyl sulfoxyde on the rough-skinned newt (Taricha granulosa)
- Author:
- Lappenbush WL and Willis DL
- Year:
- 1 971
- Bibliographic source:
- Toxicology and Applied Pharmacology, 18, 141-150
Materials and methods
Test material
- Reference substance name:
- Dimethyl sulfoxide
- EC Number:
- 200-664-3
- EC Name:
- Dimethyl sulfoxide
- Cas Number:
- 67-68-5
- Molecular formula:
- C2H6OS
- IUPAC Name:
- dimethyl sulfoxide
Constituent 1
Results and discussion
Any other information on results incl. tables
Species: amphibians
News were collected during the summer and spring, acclimated for 10 days at 10°C, weighed, treated with DMSO and maintained in an unfed state which simulated winter conditions.
Intraperitoneal injections of 15 g DMSO/kg or immersion in 2% DMSO were determined to be lethal threshold doses for newts. Death was rapid.
In addition to a transient increase in the body weight of the DMSO-treated animals, other changes were observed:
- a reduction in respiration to 70% that of the controls
- an increase in the weights of spleen (by day 1, the average spleen weight was over twice that of the controls), liver (33% increase after 24 h), and abdominal fat (150% increase after 20 days).
Lethality was attributed primarily to irreversible changes in the permeability of the skin, causing a water imbalance, hyperhydratation and death. The reduced respiratory rate increased the mortality rate
Applicant's summary and conclusion
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